Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SUM225CWN | HER2amp | Basal A | Methotrexate | DHFR | Metabolism | 0.00427 | uM | 7534.084 | 1.0064 | 1.0145 | 0.8905 | |
| SUM225CWN | HER2amp | Basal A | Methotrexate | DHFR | Metabolism | 0.0213 | uM | 7534.084 | 0.9876 | 0.9721 | 0.8905 | |
| SUM225CWN | HER2amp | Basal A | Methotrexate | DHFR | Metabolism | 0.107 | uM | 7534.084 | 0.9608 | 0.9122 | 0.8905 | |
| SUM225CWN | HER2amp | Basal A | Methotrexate | DHFR | Metabolism | 0.533 | uM | 7534.084 | 0.9990 | 0.9978 | 0.8905 | |
| SUM225CWN | HER2amp | Basal A | Methotrexate | DHFR | Metabolism | 2.67 | uM | 7534.084 | 1.0395 | 1.0888 | 0.8905 | |
| SUM225CWN | HER2amp | Basal A | Methotrexate | DHFR | Metabolism | 13.3 | uM | 7534.084 | 1.0016 | 1.0035 | 0.8905 | |
| SUM225CWN | HER2amp | Basal A | Methotrexate | DHFR | Metabolism | 66.7 | uM | 7534.084 | 0.9803 | 0.9557 | 0.8905 | |
| SUM225CWN | HER2amp | Basal A | Methotrexate | DHFR | Metabolism | 333 | uM | 7534.084 | 0.9936 | 0.9856 | 0.8905 | |
| SUM229PE | TNBC | - | Methotrexate | DHFR | Metabolism | 0.000853 | uM | 7537.084 | 0.9715 | 0.9693 | 1.8684 | |
| SUM229PE | TNBC | - | Methotrexate | DHFR | Metabolism | 0.00427 | uM | 7537.084 | 0.9512 | 0.9472 | 1.8684 | |
| SUM229PE | TNBC | - | Methotrexate | DHFR | Metabolism | 0.0213 | uM | 7537.084 | 0.9773 | 0.9755 | 1.8684 | |
| SUM229PE | TNBC | - | Methotrexate | DHFR | Metabolism | 0.107 | uM | 7537.084 | 0.9557 | 0.9521 | 1.8684 | |
| SUM229PE | TNBC | - | Methotrexate | DHFR | Metabolism | 0.533 | uM | 7537.084 | 0.7310 | 0.6912 | 1.8684 | |
| SUM229PE | TNBC | - | Methotrexate | DHFR | Metabolism | 2.67 | uM | 7537.084 | 0.7813 | 0.7526 | 1.8684 | |
| SUM229PE | TNBC | - | Methotrexate | DHFR | Metabolism | 13.3 | uM | 7537.084 | 0.7146 | 0.6708 | 1.8684 | |
| SUM229PE | TNBC | - | Methotrexate | DHFR | Metabolism | 66.7 | uM | 7537.084 | 0.7494 | 0.7138 | 1.8684 | |
| SUM229PE | TNBC | - | Methotrexate | DHFR | Metabolism | 333 | uM | 7537.084 | 0.7150 | 0.6713 | 1.8684 | |
| SUM52PE | HR+ | Luminal | Methotrexate | DHFR | Metabolism | 0.000853 | uM | 7541.084 | 1.0831 | 1.1365 | 1.2092 | |
| SUM52PE | HR+ | Luminal | Methotrexate | DHFR | Metabolism | 0.00427 | uM | 7541.084 | 0.9791 | 0.9654 | 1.2092 | |
| SUM52PE | HR+ | Luminal | Methotrexate | DHFR | Metabolism | 0.0213 | uM | 7541.084 | 1.0437 | 1.0720 | 1.2092 | |
| SUM52PE | HR+ | Luminal | Methotrexate | DHFR | Metabolism | 0.107 | uM | 7541.084 | 0.9630 | 0.9387 | 1.2092 | |
| SUM52PE | HR+ | Luminal | Methotrexate | DHFR | Metabolism | 0.533 | uM | 7541.084 | 0.9647 | 0.9414 | 1.2092 | |
| SUM52PE | HR+ | Luminal | Methotrexate | DHFR | Metabolism | 2.67 | uM | 7541.084 | 0.9841 | 0.9737 | 1.2092 | |
| SUM52PE | HR+ | Luminal | Methotrexate | DHFR | Metabolism | 13.3 | uM | 7541.084 | 1.0293 | 1.0483 | 1.2092 | |
| SUM52PE | HR+ | Luminal | Methotrexate | DHFR | Metabolism | 66.7 | uM | 7541.084 | 1.0107 | 1.0177 | 1.2092 |