Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| MDA-MB-453 | TNBC | Luminal | Methotrexate | DHFR | Metabolism | 0.000853 | uM | 7517.084 | 0.9621 | 0.9458 | 1.4076 | |
| MDA-MB-453 | TNBC | Luminal | Methotrexate | DHFR | Metabolism | 0.00427 | uM | 7517.084 | 0.9451 | 0.9214 | 1.4076 | |
| MDA-MB-453 | TNBC | Luminal | Methotrexate | DHFR | Metabolism | 0.0213 | uM | 7517.084 | 0.9536 | 0.9336 | 1.4076 | |
| MDA-MB-453 | TNBC | Luminal | Methotrexate | DHFR | Metabolism | 0.107 | uM | 7517.084 | 0.8632 | 0.8015 | 1.4076 | |
| MDA-MB-453 | TNBC | Luminal | Methotrexate | DHFR | Metabolism | 0.533 | uM | 7517.084 | 0.7879 | 0.6884 | 1.4076 | |
| MDA-MB-453 | TNBC | Luminal | Methotrexate | DHFR | Metabolism | 2.67 | uM | 7517.084 | 0.8411 | 0.7687 | 1.4076 | |
| MDA-MB-453 | TNBC | Luminal | Methotrexate | DHFR | Metabolism | 13.3 | uM | 7517.084 | 0.8514 | 0.7840 | 1.4076 | |
| MDA-MB-453 | TNBC | Luminal | Methotrexate | DHFR | Metabolism | 66.7 | uM | 7517.084 | 0.8118 | 0.7247 | 1.4076 | |
| MDA-MB-453 | TNBC | Luminal | Methotrexate | DHFR | Metabolism | 333 | uM | 7517.084 | 0.7674 | 0.6571 | 1.4076 | |
| MDA-MB-453 | TNBC | Luminal | Methotrexate | DHFR | Metabolism | 0.000853 | uM | 7518.084 | 1.0025 | 1.0038 | 1.3244 | |
| MDA-MB-453 | TNBC | Luminal | Methotrexate | DHFR | Metabolism | 0.00427 | uM | 7518.084 | 0.9895 | 0.9841 | 1.3244 | |
| MDA-MB-453 | TNBC | Luminal | Methotrexate | DHFR | Metabolism | 0.0213 | uM | 7518.084 | 1.0740 | 1.1108 | 1.3244 | |
| MDA-MB-453 | TNBC | Luminal | Methotrexate | DHFR | Metabolism | 0.107 | uM | 7518.084 | 0.9311 | 0.8950 | 1.3244 | |
| MDA-MB-453 | TNBC | Luminal | Methotrexate | DHFR | Metabolism | 0.533 | uM | 7518.084 | 0.8295 | 0.7368 | 1.3244 | |
| MDA-MB-453 | TNBC | Luminal | Methotrexate | DHFR | Metabolism | 2.67 | uM | 7518.084 | 0.8713 | 0.8023 | 1.3244 | |
| MDA-MB-453 | TNBC | Luminal | Methotrexate | DHFR | Metabolism | 13.3 | uM | 7518.084 | 0.8694 | 0.7995 | 1.3244 | |
| MDA-MB-453 | TNBC | Luminal | Methotrexate | DHFR | Metabolism | 66.7 | uM | 7518.084 | 0.8321 | 0.7409 | 1.3244 | |
| MDA-MB-453 | TNBC | Luminal | Methotrexate | DHFR | Metabolism | 333 | uM | 7518.084 | 0.9079 | 0.8593 | 1.3244 | |
| MX1 | Unknown | Unknown | Methotrexate | DHFR | Metabolism | 0.000853 | uM | 7523.084 | 0.9487 | 0.8872 | 0.9069 | |
| MX1 | Unknown | Unknown | Methotrexate | DHFR | Metabolism | 0.00427 | uM | 7523.084 | 0.9321 | 0.8508 | 0.9069 | |
| MX1 | Unknown | Unknown | Methotrexate | DHFR | Metabolism | 0.0213 | uM | 7523.084 | 0.7028 | 0.3556 | 0.9069 | |
| MX1 | Unknown | Unknown | Methotrexate | DHFR | Metabolism | 0.107 | uM | 7523.084 | 0.6049 | 0.1488 | 0.9069 | |
| MX1 | Unknown | Unknown | Methotrexate | DHFR | Metabolism | 0.533 | uM | 7523.084 | 0.5947 | 0.1276 | 0.9069 | |
| MX1 | Unknown | Unknown | Methotrexate | DHFR | Metabolism | 2.67 | uM | 7523.084 | 0.6443 | 0.2317 | 0.9069 | |
| MX1 | Unknown | Unknown | Methotrexate | DHFR | Metabolism | 13.3 | uM | 7523.084 | 0.5390 | 0.0117 | 0.9069 |