Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Hs 578T | TNBC | Basal B | Lapatinib | EGFR/HER2 | ErbB | 0.0000427 | uM | 7475.098 | 1.1361 | 1.1148 | 2.2876 | |
| Hs 578T | TNBC | Basal B | Lapatinib | EGFR/HER2 | ErbB | 0.000213 | uM | 7475.098 | 1.0057 | 1.0050 | 2.2876 | |
| Hs 578T | TNBC | Basal B | Lapatinib | EGFR/HER2 | ErbB | 0.00107 | uM | 7475.098 | 0.9698 | 0.9734 | 2.2876 | |
| Hs 578T | TNBC | Basal B | Lapatinib | EGFR/HER2 | ErbB | 0.00533 | uM | 7475.098 | 1.1031 | 1.0877 | 2.2876 | |
| Hs 578T | TNBC | Basal B | Lapatinib | EGFR/HER2 | ErbB | 0.0267 | uM | 7475.098 | 1.0958 | 1.0816 | 2.2876 | |
| Hs 578T | TNBC | Basal B | Lapatinib | EGFR/HER2 | ErbB | 0.133 | uM | 7475.098 | 0.9344 | 0.9415 | 2.2876 | |
| Hs 578T | TNBC | Basal B | Lapatinib | EGFR/HER2 | ErbB | 0.667 | uM | 7475.098 | 1.0077 | 1.0068 | 2.2876 | |
| Hs 578T | TNBC | Basal B | Lapatinib | EGFR/HER2 | ErbB | 3.33 | uM | 7475.098 | 1.1777 | 1.1482 | 2.2876 | |
| Hs 578T | TNBC | Basal B | Lapatinib | EGFR/HER2 | ErbB | 16.7 | uM | 7475.098 | 1.0106 | 1.0092 | 2.2876 | |
| LY2 | HR+ | Luminal | Lapatinib | EGFR/HER2 | ErbB | 0.0000427 | uM | 7477.098 | 0.7492 | 0.6331 | 1.4247 | |
| LY2 | HR+ | Luminal | Lapatinib | EGFR/HER2 | ErbB | 0.000213 | uM | 7477.098 | 0.9839 | 0.9774 | 1.4247 | |
| LY2 | HR+ | Luminal | Lapatinib | EGFR/HER2 | ErbB | 0.00107 | uM | 7477.098 | 0.8734 | 0.8187 | 1.4247 | |
| LY2 | HR+ | Luminal | Lapatinib | EGFR/HER2 | ErbB | 0.00533 | uM | 7477.098 | 1.0071 | 1.0100 | 1.4247 | |
| LY2 | HR+ | Luminal | Lapatinib | EGFR/HER2 | ErbB | 0.0267 | uM | 7477.098 | 0.8656 | 0.8074 | 1.4247 | |
| LY2 | HR+ | Luminal | Lapatinib | EGFR/HER2 | ErbB | 0.133 | uM | 7477.098 | 1.2712 | 1.3669 | 1.4247 | |
| LY2 | HR+ | Luminal | Lapatinib | EGFR/HER2 | ErbB | 0.667 | uM | 7477.098 | 0.8981 | 0.8546 | 1.4247 | |
| LY2 | HR+ | Luminal | Lapatinib | EGFR/HER2 | ErbB | 3.33 | uM | 7477.098 | 1.0741 | 1.1030 | 1.4247 | |
| LY2 | HR+ | Luminal | Lapatinib | EGFR/HER2 | ErbB | 16.7 | uM | 7477.098 | 0.8456 | 0.7778 | 1.4247 | |
| MB 157 | Unknown | Unknown | Lapatinib | EGFR/HER2 | ErbB | 0.0000427 | uM | 7482.098 | 0.9949 | 0.9954 | 2.2478 | |
| MB 157 | Unknown | Unknown | Lapatinib | EGFR/HER2 | ErbB | 0.000213 | uM | 7482.098 | 0.9690 | 0.9721 | 2.2478 | |
| MB 157 | Unknown | Unknown | Lapatinib | EGFR/HER2 | ErbB | 0.00107 | uM | 7482.098 | 0.9659 | 0.9694 | 2.2478 | |
| MB 157 | Unknown | Unknown | Lapatinib | EGFR/HER2 | ErbB | 0.00533 | uM | 7482.098 | 0.9650 | 0.9685 | 2.2478 | |
| MB 157 | Unknown | Unknown | Lapatinib | EGFR/HER2 | ErbB | 0.0267 | uM | 7482.098 | 0.9377 | 0.9435 | 2.2478 | |
| MB 157 | Unknown | Unknown | Lapatinib | EGFR/HER2 | ErbB | 0.133 | uM | 7482.098 | 0.9266 | 0.9333 | 2.2478 | |
| MB 157 | Unknown | Unknown | Lapatinib | EGFR/HER2 | ErbB | 0.667 | uM | 7482.098 | 0.8320 | 0.8429 | 2.2478 |