Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| CAMA-1 | HR+ | Luminal | Lapatinib | EGFR/HER2 | ErbB | 0.0267 | uM | 5912.098 | 0.9833 | 0.9683 | 1.0559 | |
| CAMA-1 | HR+ | Luminal | Lapatinib | EGFR/HER2 | ErbB | 0.133 | uM | 5912.098 | 0.9918 | 0.9844 | 1.0559 | |
| CAMA-1 | HR+ | Luminal | Lapatinib | EGFR/HER2 | ErbB | 0.667 | uM | 5912.098 | 1.0149 | 1.0283 | 1.0559 | |
| CAMA-1 | HR+ | Luminal | Lapatinib | EGFR/HER2 | ErbB | 3.33 | uM | 5912.098 | 0.9756 | 0.9538 | 1.0559 | |
| CAMA-1 | HR+ | Luminal | Lapatinib | EGFR/HER2 | ErbB | 16.7 | uM | 5912.098 | 0.9665 | 0.9364 | 1.0559 | |
| HCC1143 | TNBC | Basal A | Lapatinib | EGFR/HER2 | ErbB | 0.0000427 | uM | 7430.098 | 1.0117 | 1.0121 | 1.9267 | |
| HCC1143 | TNBC | Basal A | Lapatinib | EGFR/HER2 | ErbB | 0.000213 | uM | 7430.098 | 1.0108 | 1.0112 | 1.9267 | |
| HCC1143 | TNBC | Basal A | Lapatinib | EGFR/HER2 | ErbB | 0.00107 | uM | 7430.098 | 1.0391 | 1.0402 | 1.9267 | |
| HCC1143 | TNBC | Basal A | Lapatinib | EGFR/HER2 | ErbB | 0.00533 | uM | 7430.098 | 1.0472 | 1.0484 | 1.9267 | |
| HCC1143 | TNBC | Basal A | Lapatinib | EGFR/HER2 | ErbB | 0.0267 | uM | 7430.098 | 1.1320 | 1.1329 | 1.9267 | |
| HCC1143 | TNBC | Basal A | Lapatinib | EGFR/HER2 | ErbB | 0.133 | uM | 7430.098 | 1.0065 | 1.0068 | 1.9267 | |
| HCC1143 | TNBC | Basal A | Lapatinib | EGFR/HER2 | ErbB | 0.667 | uM | 7430.098 | 1.0266 | 1.0274 | 1.9267 | |
| HCC1143 | TNBC | Basal A | Lapatinib | EGFR/HER2 | ErbB | 3.33 | uM | 7430.098 | 0.9164 | 0.9114 | 1.9267 | |
| HCC1143 | TNBC | Basal A | Lapatinib | EGFR/HER2 | ErbB | 16.7 | uM | 7430.098 | 1.0155 | 1.0160 | 1.9267 | |
| HCC1187 | TNBC | Basal A | Lapatinib | EGFR/HER2 | ErbB | 0.0000427 | uM | 7431.098 | 1.0433 | 1.0567 | 1.5161 | |
| HCC1187 | TNBC | Basal A | Lapatinib | EGFR/HER2 | ErbB | 0.000213 | uM | 7431.098 | 0.9850 | 0.9802 | 1.5161 | |
| HCC1187 | TNBC | Basal A | Lapatinib | EGFR/HER2 | ErbB | 0.00107 | uM | 7431.098 | 1.0124 | 1.0164 | 1.5161 | |
| HCC1187 | TNBC | Basal A | Lapatinib | EGFR/HER2 | ErbB | 0.00533 | uM | 7431.098 | 0.9860 | 0.9815 | 1.5161 | |
| HCC1187 | TNBC | Basal A | Lapatinib | EGFR/HER2 | ErbB | 0.0267 | uM | 7431.098 | 1.0104 | 1.0137 | 1.5161 | |
| HCC1187 | TNBC | Basal A | Lapatinib | EGFR/HER2 | ErbB | 0.133 | uM | 7431.098 | 0.9535 | 0.9381 | 1.5161 | |
| HCC1187 | TNBC | Basal A | Lapatinib | EGFR/HER2 | ErbB | 0.667 | uM | 7431.098 | 0.9741 | 0.9657 | 1.5161 | |
| HCC1187 | TNBC | Basal A | Lapatinib | EGFR/HER2 | ErbB | 3.33 | uM | 7431.098 | 0.8624 | 0.8139 | 1.5161 | |
| HCC1187 | TNBC | Basal A | Lapatinib | EGFR/HER2 | ErbB | 16.7 | uM | 7431.098 | 0.8852 | 0.8454 | 1.5161 | |
| HCC1187 | TNBC | Basal A | Lapatinib | EGFR/HER2 | ErbB | 0.0000427 | uM | 7432.098 | 1.0410 | 1.0786 | 1.0423 | |
| HCC1187 | TNBC | Basal A | Lapatinib | EGFR/HER2 | ErbB | 0.000213 | uM | 7432.098 | 1.0175 | 1.0336 | 1.0423 |