Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| MDA-MB-134-VI | HR+ | Luminal | L-779450 | BRAF | MAPK | 0.00213 | uM | 10998.149 | 1.0018 | 1.0046 | 0.7732 | |
| MDA-MB-134-VI | HR+ | Luminal | L-779450 | BRAF | MAPK | 0.0107 | uM | 10998.149 | 1.0536 | 1.1398 | 0.7732 | |
| MDA-MB-134-VI | HR+ | Luminal | L-779450 | BRAF | MAPK | 0.0533 | uM | 10998.149 | 0.9721 | 0.9282 | 0.7732 | |
| MDA-MB-134-VI | HR+ | Luminal | L-779450 | BRAF | MAPK | 0.267 | uM | 10998.149 | 0.9884 | 0.9701 | 0.7732 | |
| MDA-MB-134-VI | HR+ | Luminal | L-779450 | BRAF | MAPK | 1.33 | uM | 10998.149 | 0.9537 | 0.8812 | 0.7732 | |
| MDA-MB-134-VI | HR+ | Luminal | L-779450 | BRAF | MAPK | 6.67 | uM | 10998.149 | 1.0408 | 1.1062 | 0.7732 | |
| MDA-MB-134-VI | HR+ | Luminal | L-779450 | BRAF | MAPK | 33.3 | uM | 10998.149 | 0.9248 | 0.8077 | 0.7732 | |
| MDA-MB-134-VI | HR+ | Luminal | L-779450 | BRAF | MAPK | 0.000128 | uM | 12206.161 | 0.9944 | 0.9895 | 1.0580 | |
| MDA-MB-134-VI | HR+ | Luminal | L-779450 | BRAF | MAPK | 0.00064 | uM | 12206.161 | 0.9282 | 0.8640 | 1.0580 | |
| MDA-MB-134-VI | HR+ | Luminal | L-779450 | BRAF | MAPK | 0.0032 | uM | 12206.161 | 1.0268 | 1.0506 | 1.0580 | |
| MDA-MB-134-VI | HR+ | Luminal | L-779450 | BRAF | MAPK | 0.016 | uM | 12206.161 | 0.9712 | 0.9456 | 1.0580 | |
| MDA-MB-134-VI | HR+ | Luminal | L-779450 | BRAF | MAPK | 0.08 | uM | 12206.161 | 0.9808 | 0.9638 | 1.0580 | |
| MDA-MB-134-VI | HR+ | Luminal | L-779450 | BRAF | MAPK | 0.4 | uM | 12206.161 | 1.0371 | 1.0701 | 1.0580 | |
| MDA-MB-134-VI | HR+ | Luminal | L-779450 | BRAF | MAPK | 2 | uM | 12206.161 | 0.9340 | 0.8750 | 1.0580 | |
| MDA-MB-134-VI | HR+ | Luminal | L-779450 | BRAF | MAPK | 10 | uM | 12206.161 | 0.8056 | 0.6304 | 1.0580 | |
| MDA-MB-134-VI | HR+ | Luminal | L-779450 | BRAF | MAPK | 50 | uM | 12206.161 | 0.4911 | 0.0212 | 1.0580 | |
| MDA-MB-157 | TNBC | Basal B | L-779450 | BRAF | MAPK | 0.0000853 | uM | 12594.166 | 0.9932 | 0.9875 | 1.0936 | |
| MDA-MB-157 | TNBC | Basal B | L-779450 | BRAF | MAPK | 0.000427 | uM | 12594.166 | 0.9527 | 0.9134 | 1.0936 | |
| MDA-MB-157 | TNBC | Basal B | L-779450 | BRAF | MAPK | 0.00213 | uM | 12594.166 | 0.9873 | 0.9768 | 1.0936 | |
| MDA-MB-157 | TNBC | Basal B | L-779450 | BRAF | MAPK | 0.0107 | uM | 12594.166 | 1.0873 | 1.1591 | 1.0936 | |
| MDA-MB-157 | TNBC | Basal B | L-779450 | BRAF | MAPK | 0.0533 | uM | 12594.166 | 1.0047 | 1.0086 | 1.0936 | |
| MDA-MB-157 | TNBC | Basal B | L-779450 | BRAF | MAPK | 0.267 | uM | 12594.166 | 1.0407 | 1.0743 | 1.0936 | |
| MDA-MB-157 | TNBC | Basal B | L-779450 | BRAF | MAPK | 1.33 | uM | 12594.166 | 0.9700 | 0.9451 | 1.0936 | |
| MDA-MB-157 | TNBC | Basal B | L-779450 | BRAF | MAPK | 6.67 | uM | 12594.166 | 0.8811 | 0.7813 | 1.0936 | |
| MDA-MB-157 | TNBC | Basal B | L-779450 | BRAF | MAPK | 33.3 | uM | 12594.166 | 0.3807 | -0.1730 | 1.0936 |