Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| MCF12A | NM | Basal B | JNK-IN-5A | JNK | JNK | 133 | uM | 10817.144 | 0.3323 | -0.0577 | 1.4640 | |
| MCF12A | NM | Basal B | JNK-IN-5A | JNK | JNK | 0.000512 | uM | 12365.168 | 0.9840 | 0.9853 | 2.1914 | |
| MCF12A | NM | Basal B | JNK-IN-5A | JNK | JNK | 0.00256 | uM | 12365.168 | 0.9393 | 0.9436 | 2.1914 | |
| MCF12A | NM | Basal B | JNK-IN-5A | JNK | JNK | 0.0128 | uM | 12365.168 | 0.9644 | 0.9672 | 2.1914 | |
| MCF12A | NM | Basal B | JNK-IN-5A | JNK | JNK | 0.064 | uM | 12365.168 | 0.9572 | 0.9605 | 2.1914 | |
| MCF12A | NM | Basal B | JNK-IN-5A | JNK | JNK | 0.32 | uM | 12365.168 | 0.9541 | 0.9575 | 2.1914 | |
| MCF12A | NM | Basal B | JNK-IN-5A | JNK | JNK | 1.6 | uM | 12365.168 | 0.9870 | 0.9881 | 2.1914 | |
| MCF12A | NM | Basal B | JNK-IN-5A | JNK | JNK | 8 | uM | 12365.168 | 0.6831 | 0.6808 | 2.1914 | |
| MCF12A | NM | Basal B | JNK-IN-5A | JNK | JNK | 40 | uM | 12365.168 | 0.8660 | 0.8729 | 2.1914 | |
| MCF12A | NM | Basal B | JNK-IN-5A | JNK | JNK | 200 | uM | 12365.168 | 0.2120 | -0.0145 | 2.1914 | |
| MCF7 | HR+ | Luminal | JNK-IN-5A | JNK | JNK | 0.000341 | uM | 10997.144 | 1.0100 | 1.0157 | 1.2750 | |
| MCF7 | HR+ | Luminal | JNK-IN-5A | JNK | JNK | 0.00171 | uM | 10997.144 | 1.0242 | 1.0378 | 1.2750 | |
| MCF7 | HR+ | Luminal | JNK-IN-5A | JNK | JNK | 0.00853 | uM | 10997.144 | 1.0341 | 1.0533 | 1.2750 | |
| MCF7 | HR+ | Luminal | JNK-IN-5A | JNK | JNK | 0.0427 | uM | 10997.144 | 1.0790 | 1.1229 | 1.2750 | |
| MCF7 | HR+ | Luminal | JNK-IN-5A | JNK | JNK | 0.213 | uM | 10997.144 | 1.0144 | 1.0225 | 1.2750 | |
| MCF7 | HR+ | Luminal | JNK-IN-5A | JNK | JNK | 1.07 | uM | 10997.144 | 1.0095 | 1.0148 | 1.2750 | |
| MCF7 | HR+ | Luminal | JNK-IN-5A | JNK | JNK | 5.33 | uM | 10997.144 | 0.5275 | 0.2110 | 1.2750 | |
| MCF7 | HR+ | Luminal | JNK-IN-5A | JNK | JNK | 26.7 | uM | 10997.144 | 1.0431 | 1.0673 | 1.2750 | |
| MCF7 | HR+ | Luminal | JNK-IN-5A | JNK | JNK | 133 | uM | 10997.144 | 0.9912 | 0.9861 | 1.2750 | |
| MDA-MB-134-VI | HR+ | Luminal | JNK-IN-5A | JNK | JNK | 0.000341 | uM | 10998.144 | 1.0380 | 1.0937 | 0.8153 | |
| MDA-MB-134-VI | HR+ | Luminal | JNK-IN-5A | JNK | JNK | 0.00171 | uM | 10998.144 | 0.9967 | 0.9918 | 0.8153 | |
| MDA-MB-134-VI | HR+ | Luminal | JNK-IN-5A | JNK | JNK | 0.00853 | uM | 10998.144 | 1.0148 | 1.0363 | 0.8153 | |
| MDA-MB-134-VI | HR+ | Luminal | JNK-IN-5A | JNK | JNK | 0.0427 | uM | 10998.144 | 1.0892 | 1.2209 | 0.8153 | |
| MDA-MB-134-VI | HR+ | Luminal | JNK-IN-5A | JNK | JNK | 0.213 | uM | 10998.144 | 1.0270 | 1.0665 | 0.8153 | |
| MDA-MB-134-VI | HR+ | Luminal | JNK-IN-5A | JNK | JNK | 1.07 | uM | 10998.144 | 1.0114 | 1.0279 | 0.8153 |