Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SUM52PE | HR+ | Luminal | Ispinesib | KSP | Kinesin | 0.000427 | uM | 7541.067 | 0.9159 | 0.8821 | 1.4459 | |
| SUM52PE | HR+ | Luminal | Ispinesib | KSP | Kinesin | 0.00213 | uM | 7541.067 | 0.9336 | 0.9072 | 1.4459 | |
| SUM52PE | HR+ | Luminal | Ispinesib | KSP | Kinesin | 0.0107 | uM | 7541.067 | 0.9174 | 0.8842 | 1.4459 | |
| SUM52PE | HR+ | Luminal | Ispinesib | KSP | Kinesin | 0.0533 | uM | 7541.067 | 0.3033 | -0.1236 | 1.4459 | |
| SUM52PE | HR+ | Luminal | Ispinesib | KSP | Kinesin | 0.267 | uM | 7541.067 | 0.2190 | -0.3003 | 1.4459 | |
| SUM52PE | HR+ | Luminal | Ispinesib | KSP | Kinesin | 1.33 | uM | 7541.067 | 0.2051 | -0.3315 | 1.4459 | |
| SUM52PE | HR+ | Luminal | Ispinesib | KSP | Kinesin | 6.67 | uM | 7541.067 | 0.0966 | -0.6028 | 1.4459 | |
| SUM52PE | HR+ | Luminal | Ispinesib | KSP | Kinesin | 33.3 | uM | 7541.067 | 0.0012 | -0.9804 | 1.4459 | |
| T47D | HR+ | Luminal | Ispinesib | KSP | Kinesin | 0.0000853 | uM | 7543.067 | 0.9875 | 0.9798 | 1.2437 | |
| T47D | HR+ | Luminal | Ispinesib | KSP | Kinesin | 0.000427 | uM | 7543.067 | 1.0124 | 1.0199 | 1.2437 | |
| T47D | HR+ | Luminal | Ispinesib | KSP | Kinesin | 0.00213 | uM | 7543.067 | 1.0458 | 1.0734 | 1.2437 | |
| T47D | HR+ | Luminal | Ispinesib | KSP | Kinesin | 0.0107 | uM | 7543.067 | 1.0669 | 1.1069 | 1.2437 | |
| T47D | HR+ | Luminal | Ispinesib | KSP | Kinesin | 0.0533 | uM | 7543.067 | 0.6957 | 0.4939 | 1.2437 | |
| T47D | HR+ | Luminal | Ispinesib | KSP | Kinesin | 0.267 | uM | 7543.067 | 0.4041 | -0.0348 | 1.2437 | |
| T47D | HR+ | Luminal | Ispinesib | KSP | Kinesin | 1.33 | uM | 7543.067 | 0.4091 | -0.0253 | 1.2437 | |
| T47D | HR+ | Luminal | Ispinesib | KSP | Kinesin | 6.67 | uM | 7543.067 | 0.1398 | -0.5890 | 1.2437 | |
| T47D | HR+ | Luminal | Ispinesib | KSP | Kinesin | 33.3 | uM | 7543.067 | 0.0005 | -0.9958 | 1.2437 | |
| T47DKBLUC | Unknown | Unknown | Ispinesib | KSP | Kinesin | 0.0000853 | uM | 7546.067 | 1.0063 | 1.0148 | 0.8509 | |
| T47DKBLUC | Unknown | Unknown | Ispinesib | KSP | Kinesin | 0.000427 | uM | 7546.067 | 1.0052 | 1.0122 | 0.8509 | |
| T47DKBLUC | Unknown | Unknown | Ispinesib | KSP | Kinesin | 0.00213 | uM | 7546.067 | 0.9811 | 0.9557 | 0.8509 | |
| T47DKBLUC | Unknown | Unknown | Ispinesib | KSP | Kinesin | 0.0107 | uM | 7546.067 | 1.0465 | 1.1097 | 0.8509 | |
| T47DKBLUC | Unknown | Unknown | Ispinesib | KSP | Kinesin | 0.0533 | uM | 7546.067 | 0.7968 | 0.5314 | 0.8509 | |
| T47DKBLUC | Unknown | Unknown | Ispinesib | KSP | Kinesin | 0.267 | uM | 7546.067 | 0.5692 | 0.0313 | 0.8509 | |
| T47DKBLUC | Unknown | Unknown | Ispinesib | KSP | Kinesin | 1.33 | uM | 7546.067 | 0.6043 | 0.1066 | 0.8509 | |
| T47DKBLUC | Unknown | Unknown | Ispinesib | KSP | Kinesin | 6.67 | uM | 7546.067 | 0.5509 | -0.0074 | 0.8509 |