Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
Download: Excel (XLSX), Comma-separated (CSV)
| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SUM229PE | TNBC | - | 5-FU | TYMS | TYMS | 154 | uM | 9860.017 | 0.5259 | 0.3752 | 1.7158 | |
| SUM229PE | TNBC | - | 5-FU | TYMS | TYMS | 769 | uM | 9860.017 | 0.3043 | -0.0002 | 1.7158 | |
| SUM229PE | TNBC | - | 5-FU | TYMS | TYMS | 3840 | uM | 9860.017 | 0.1210 | -0.4160 | 1.7158 | |
| SUM229PE | TNBC | - | 5-FU | TYMS | TYMS | 19200 | uM | 9860.017 | 0.0578 | -0.6201 | 1.7158 | |
| SUM52PE | HR+ | Luminal | 5-FU | TYMS | TYMS | 0.0492 | uM | 7923.017 | 0.8070 | 0.4205 | 0.6267 | |
| SUM52PE | HR+ | Luminal | 5-FU | TYMS | TYMS | 0.246 | uM | 7923.017 | 0.8760 | 0.6191 | 0.6267 | |
| SUM52PE | HR+ | Luminal | 5-FU | TYMS | TYMS | 1.23 | uM | 7923.017 | 0.6905 | 0.1077 | 0.6267 | |
| SUM52PE | HR+ | Luminal | 5-FU | TYMS | TYMS | 6.15 | uM | 7923.017 | 0.8348 | 0.4995 | 0.6267 | |
| SUM52PE | HR+ | Luminal | 5-FU | TYMS | TYMS | 30.7 | uM | 7923.017 | 0.8644 | 0.5851 | 0.6267 | |
| SUM52PE | HR+ | Luminal | 5-FU | TYMS | TYMS | 154 | uM | 7923.017 | 0.7357 | 0.2257 | 0.6267 | |
| SUM52PE | HR+ | Luminal | 5-FU | TYMS | TYMS | 769 | uM | 7923.017 | 0.5306 | -0.2725 | 0.6267 | |
| SUM52PE | HR+ | Luminal | 5-FU | TYMS | TYMS | 3840 | uM | 7923.017 | 0.3793 | -0.5741 | 0.6267 | |
| SUM52PE | HR+ | Luminal | 5-FU | TYMS | TYMS | 19200 | uM | 7923.017 | 0.0704 | -0.9710 | 0.6267 | |
| SUM52PE | HR+ | Luminal | 5-FU | TYMS | TYMS | 0.0492 | uM | 9878.017 | 1.0020 | 1.0030 | 1.3463 | |
| SUM52PE | HR+ | Luminal | 5-FU | TYMS | TYMS | 0.246 | uM | 9878.017 | 1.0510 | 1.0753 | 1.3463 | |
| SUM52PE | HR+ | Luminal | 5-FU | TYMS | TYMS | 1.23 | uM | 9878.017 | 0.9023 | 0.8529 | 1.3463 | |
| SUM52PE | HR+ | Luminal | 5-FU | TYMS | TYMS | 6.15 | uM | 9878.017 | 0.9441 | 0.9164 | 1.3463 | |
| SUM52PE | HR+ | Luminal | 5-FU | TYMS | TYMS | 30.7 | uM | 9878.017 | 0.6986 | 0.5323 | 1.3463 | |
| SUM52PE | HR+ | Luminal | 5-FU | TYMS | TYMS | 154 | uM | 9878.017 | 0.4807 | 0.1608 | 1.3463 | |
| SUM52PE | HR+ | Luminal | 5-FU | TYMS | TYMS | 769 | uM | 9878.017 | 0.2510 | -0.2836 | 1.3463 | |
| SUM52PE | HR+ | Luminal | 5-FU | TYMS | TYMS | 3840 | uM | 9878.017 | 0.1003 | -0.6377 | 1.3463 | |
| SUM52PE | HR+ | Luminal | 5-FU | TYMS | TYMS | 19200 | uM | 9878.017 | 0.0633 | -0.7426 | 1.3463 | |
| UACC-812 | HER2amp | Luminal | 5-FU | TYMS | TYMS | 0.0492 | uM | 7926.017 | 0.9877 | 0.9724 | 0.8896 | |
| UACC-812 | HER2amp | Luminal | 5-FU | TYMS | TYMS | 0.246 | uM | 7926.017 | 1.1463 | 1.3318 | 0.8896 | |
| UACC-812 | HER2amp | Luminal | 5-FU | TYMS | TYMS | 1.23 | uM | 7926.017 | 0.9625 | 0.9159 | 0.8896 |