Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| HCC1569 | HER2amp | Basal A | GSK461364 | PLK1 | PLK | 0.267 | uM | 9347.001 | 0.7178 | 0.6034 | 1.5003 | |
| HCC1569 | HER2amp | Basal A | GSK461364 | PLK1 | PLK | 1.33 | uM | 9347.001 | 0.7692 | 0.6791 | 1.5003 | |
| HCC1569 | HER2amp | Basal A | GSK461364 | PLK1 | PLK | 6.67 | uM | 9347.001 | 0.5882 | 0.4041 | 1.5003 | |
| HCC1569 | HER2amp | Basal A | GSK461364 | PLK1 | PLK | 33.3 | uM | 9347.001 | 0.3053 | -0.0931 | 1.5003 | |
| HCC1806 | TNBC | Basal A | GSK461364 | PLK1 | PLK | 0.0000853 | uM | 9376.001 | 1.0088 | 1.0096 | 1.8315 | |
| HCC1806 | TNBC | Basal A | GSK461364 | PLK1 | PLK | 0.000427 | uM | 9376.001 | 1.0197 | 1.0215 | 1.8315 | |
| HCC1806 | TNBC | Basal A | GSK461364 | PLK1 | PLK | 0.00213 | uM | 9376.001 | 0.9971 | 0.9969 | 1.8315 | |
| HCC1806 | TNBC | Basal A | GSK461364 | PLK1 | PLK | 0.0107 | uM | 9376.001 | 0.6690 | 0.6059 | 1.8315 | |
| HCC1806 | TNBC | Basal A | GSK461364 | PLK1 | PLK | 0.0533 | uM | 9376.001 | 0.1063 | -0.4117 | 1.8315 | |
| HCC1806 | TNBC | Basal A | GSK461364 | PLK1 | PLK | 0.267 | uM | 9376.001 | 0.1456 | -0.3016 | 1.8315 | |
| HCC1806 | TNBC | Basal A | GSK461364 | PLK1 | PLK | 1.33 | uM | 9376.001 | 0.2495 | -0.0629 | 1.8315 | |
| HCC1806 | TNBC | Basal A | GSK461364 | PLK1 | PLK | 6.67 | uM | 9376.001 | 0.2376 | -0.0875 | 1.8315 | |
| HCC1806 | TNBC | Basal A | GSK461364 | PLK1 | PLK | 33.3 | uM | 9376.001 | 0.0096 | -0.8414 | 1.8315 | |
| HCC1937 | TNBC | Basal A | GSK461364 | PLK1 | PLK | 0.0000853 | uM | 7833.001 | 0.6705 | 0.3652 | 1.0468 | |
| HCC1937 | TNBC | Basal A | GSK461364 | PLK1 | PLK | 0.000427 | uM | 7833.001 | 1.0544 | 1.1038 | 1.0468 | |
| HCC1937 | TNBC | Basal A | GSK461364 | PLK1 | PLK | 0.00213 | uM | 7833.001 | 0.7847 | 0.5864 | 1.0468 | |
| HCC1937 | TNBC | Basal A | GSK461364 | PLK1 | PLK | 0.0107 | uM | 7833.001 | 0.4055 | -0.1556 | 1.0468 | |
| HCC1937 | TNBC | Basal A | GSK461364 | PLK1 | PLK | 0.0533 | uM | 7833.001 | 0.5226 | 0.0760 | 1.0468 | |
| HCC1937 | TNBC | Basal A | GSK461364 | PLK1 | PLK | 0.267 | uM | 7833.001 | 0.4072 | -0.1523 | 1.0468 | |
| HCC1937 | TNBC | Basal A | GSK461364 | PLK1 | PLK | 1.33 | uM | 7833.001 | 0.3715 | -0.2233 | 1.0468 | |
| HCC1937 | TNBC | Basal A | GSK461364 | PLK1 | PLK | 6.67 | uM | 7833.001 | 0.2346 | -0.4994 | 1.0468 | |
| HCC1937 | TNBC | Basal A | GSK461364 | PLK1 | PLK | 33.3 | uM | 7833.001 | 0.1037 | -0.7706 | 1.0468 | |
| HCC1937 | TNBC | Basal A | GSK461364 | PLK1 | PLK | 0.0000853 | uM | 7834.001 | 0.9584 | 0.9584 | 2.0219 | |
| HCC1937 | TNBC | Basal A | GSK461364 | PLK1 | PLK | 0.000427 | uM | 7834.001 | 1.0508 | 1.0497 | 2.0219 | |
| HCC1937 | TNBC | Basal A | GSK461364 | PLK1 | PLK | 0.00213 | uM | 7834.001 | 0.7585 | 0.7444 | 2.0219 |