Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| HCC1937 | TNBC | Basal A | GSK461364 | PLK1 | PLK | 0.0107 | uM | 7834.001 | 0.6195 | 0.5782 | 2.0219 | |
| HCC1937 | TNBC | Basal A | GSK461364 | PLK1 | PLK | 0.0533 | uM | 7834.001 | 0.6000 | 0.5535 | 2.0219 | |
| HCC1937 | TNBC | Basal A | GSK461364 | PLK1 | PLK | 0.267 | uM | 7834.001 | 0.4259 | 0.3113 | 2.0219 | |
| HCC1937 | TNBC | Basal A | GSK461364 | PLK1 | PLK | 1.33 | uM | 7834.001 | 0.3424 | 0.1772 | 2.0219 | |
| HCC1937 | TNBC | Basal A | GSK461364 | PLK1 | PLK | 6.67 | uM | 7834.001 | 0.1922 | -0.1153 | 2.0219 | |
| HCC1937 | TNBC | Basal A | GSK461364 | PLK1 | PLK | 33.3 | uM | 7834.001 | 0.1481 | -0.2224 | 2.0219 | |
| HCC1937 | TNBC | Basal A | GSK461364 | PLK1 | PLK | 0.0000853 | uM | 10262.001 | 0.9846 | 0.9498 | 0.6105 | |
| HCC1937 | TNBC | Basal A | GSK461364 | PLK1 | PLK | 0.000427 | uM | 10262.001 | 1.0292 | 1.0964 | 0.6105 | |
| HCC1937 | TNBC | Basal A | GSK461364 | PLK1 | PLK | 0.00213 | uM | 10262.001 | 0.9804 | 0.9361 | 0.6105 | |
| HCC1937 | TNBC | Basal A | GSK461364 | PLK1 | PLK | 0.0107 | uM | 10262.001 | 0.9132 | 0.7236 | 0.6105 | |
| HCC1937 | TNBC | Basal A | GSK461364 | PLK1 | PLK | 0.0533 | uM | 10262.001 | 0.7335 | 0.2037 | 0.6105 | |
| HCC1937 | TNBC | Basal A | GSK461364 | PLK1 | PLK | 0.267 | uM | 10262.001 | 0.6657 | 0.0270 | 0.6105 | |
| HCC1937 | TNBC | Basal A | GSK461364 | PLK1 | PLK | 1.33 | uM | 10262.001 | 0.5379 | -0.2757 | 0.6105 | |
| HCC1937 | TNBC | Basal A | GSK461364 | PLK1 | PLK | 6.67 | uM | 10262.001 | 0.4315 | -0.4952 | 0.6105 | |
| HCC1937 | TNBC | Basal A | GSK461364 | PLK1 | PLK | 33.3 | uM | 10262.001 | 0.1922 | -0.8658 | 0.6105 | |
| HCC1954 | HER2amp | Basal A | GSK461364 | PLK1 | PLK | 0.0000853 | uM | 7837.001 | 1.0075 | 1.0097 | 1.5358 | |
| HCC1954 | HER2amp | Basal A | GSK461364 | PLK1 | PLK | 0.000427 | uM | 7837.001 | 1.0960 | 1.1230 | 1.5358 | |
| HCC1954 | HER2amp | Basal A | GSK461364 | PLK1 | PLK | 0.00213 | uM | 7837.001 | 0.9832 | 0.9781 | 1.5358 | |
| HCC1954 | HER2amp | Basal A | GSK461364 | PLK1 | PLK | 0.0107 | uM | 7837.001 | 0.3544 | 0.0179 | 1.5358 | |
| HCC1954 | HER2amp | Basal A | GSK461364 | PLK1 | PLK | 0.0533 | uM | 7837.001 | 0.1000 | -0.5535 | 1.5358 | |
| HCC1954 | HER2amp | Basal A | GSK461364 | PLK1 | PLK | 0.267 | uM | 7837.001 | 0.1941 | -0.3122 | 1.5358 | |
| HCC1954 | HER2amp | Basal A | GSK461364 | PLK1 | PLK | 1.33 | uM | 7837.001 | 0.2482 | -0.1927 | 1.5358 | |
| HCC1954 | HER2amp | Basal A | GSK461364 | PLK1 | PLK | 6.67 | uM | 7837.001 | 0.1657 | -0.3796 | 1.5358 | |
| HCC1954 | HER2amp | Basal A | GSK461364 | PLK1 | PLK | 33.3 | uM | 7837.001 | 0.1235 | -0.4876 | 1.5358 | |
| HCC1954 | HER2amp | Basal A | GSK461364 | PLK1 | PLK | 0.0000853 | uM | 7839.001 | 0.9435 | 0.9395 | 1.8919 |