Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| UACC-893 | HER2amp | Luminal | GSK1070916 | AURK | AURK | 0.0533 | uM | 9953.001 | 1.0224 | 1.1355 | 0.3377 | |
| UACC-893 | HER2amp | Luminal | GSK1070916 | AURK | AURK | 0.267 | uM | 9953.001 | 0.9545 | 0.7426 | 0.3377 | |
| UACC-893 | HER2amp | Luminal | GSK1070916 | AURK | AURK | 1.33 | uM | 9953.001 | 0.9410 | 0.6702 | 0.3377 | |
| UACC-893 | HER2amp | Luminal | GSK1070916 | AURK | AURK | 6.67 | uM | 9953.001 | 0.8511 | 0.2407 | 0.3377 | |
| UACC-893 | HER2amp | Luminal | GSK1070916 | AURK | AURK | 33.3 | uM | 9953.001 | 0.6214 | -0.5113 | 0.3377 | |
| ZR-75-1 | HR+ | Luminal | GSK1070916 | AURK | AURK | 0.0000853 | uM | 7931.001 | 1.0325 | 1.0502 | 1.2900 | |
| ZR-75-1 | HR+ | Luminal | GSK1070916 | AURK | AURK | 0.000427 | uM | 7931.001 | 0.9654 | 0.9462 | 1.2900 | |
| ZR-75-1 | HR+ | Luminal | GSK1070916 | AURK | AURK | 0.00213 | uM | 7931.001 | 1.0283 | 1.0437 | 1.2900 | |
| ZR-75-1 | HR+ | Luminal | GSK1070916 | AURK | AURK | 0.0107 | uM | 7931.001 | 0.9555 | 0.9306 | 1.2900 | |
| ZR-75-1 | HR+ | Luminal | GSK1070916 | AURK | AURK | 0.0533 | uM | 7931.001 | 0.8624 | 0.7832 | 1.2900 | |
| ZR-75-1 | HR+ | Luminal | GSK1070916 | AURK | AURK | 0.267 | uM | 7931.001 | 0.8498 | 0.7630 | 1.2900 | |
| ZR-75-1 | HR+ | Luminal | GSK1070916 | AURK | AURK | 1.33 | uM | 7931.001 | 0.8504 | 0.7639 | 1.2900 | |
| ZR-75-1 | HR+ | Luminal | GSK1070916 | AURK | AURK | 6.67 | uM | 7931.001 | 0.8097 | 0.6981 | 1.2900 | |
| ZR-75-1 | HR+ | Luminal | GSK1070916 | AURK | AURK | 33.3 | uM | 7931.001 | 0.5852 | 0.3202 | 1.2900 | |
| ZR-75-1 | HR+ | Luminal | GSK1070916 | AURK | AURK | 0.0000853 | uM | 7932.001 | 0.9294 | 0.8621 | 1.0256 | |
| ZR-75-1 | HR+ | Luminal | GSK1070916 | AURK | AURK | 0.000427 | uM | 7932.001 | 0.9735 | 0.9482 | 1.0256 | |
| ZR-75-1 | HR+ | Luminal | GSK1070916 | AURK | AURK | 0.00213 | uM | 7932.001 | 1.0491 | 1.0958 | 1.0256 | |
| ZR-75-1 | HR+ | Luminal | GSK1070916 | AURK | AURK | 0.0107 | uM | 7932.001 | 0.9554 | 0.9129 | 1.0256 | |
| ZR-75-1 | HR+ | Luminal | GSK1070916 | AURK | AURK | 0.0533 | uM | 7932.001 | 0.9746 | 0.9504 | 1.0256 | |
| ZR-75-1 | HR+ | Luminal | GSK1070916 | AURK | AURK | 0.267 | uM | 7932.001 | 0.9462 | 0.8949 | 1.0256 | |
| ZR-75-1 | HR+ | Luminal | GSK1070916 | AURK | AURK | 1.33 | uM | 7932.001 | 1.0109 | 1.0213 | 1.0256 | |
| ZR-75-1 | HR+ | Luminal | GSK1070916 | AURK | AURK | 6.67 | uM | 7932.001 | 0.8724 | 0.7508 | 1.0256 | |
| ZR-75-1 | HR+ | Luminal | GSK1070916 | AURK | AURK | 33.3 | uM | 7932.001 | 0.6298 | 0.2743 | 1.0256 | |
| ZR-75-1 | HR+ | Luminal | GSK1070916 | AURK | AURK | 0.0000853 | uM | 9958.001 | 1.0053 | 1.0206 | 0.5164 | |
| ZR-75-1 | HR+ | Luminal | GSK1070916 | AURK | AURK | 0.000427 | uM | 9958.001 | 0.9788 | 0.9188 | 0.5164 |