Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| HCC1419 | HER2amp | Luminal | GSK461364 | PLK1 | PLK | 0.00213 | uM | 7819.001 | 1.0023 | 1.0095 | 0.4919 | |
| HCC1419 | HER2amp | Luminal | GSK461364 | PLK1 | PLK | 0.0107 | uM | 7819.001 | 0.9677 | 0.8709 | 0.4919 | |
| HCC1419 | HER2amp | Luminal | GSK461364 | PLK1 | PLK | 0.0533 | uM | 7819.001 | 0.8921 | 0.5857 | 0.4919 | |
| HCC1419 | HER2amp | Luminal | GSK461364 | PLK1 | PLK | 0.267 | uM | 7819.001 | 0.9790 | 0.9154 | 0.4919 | |
| HCC1419 | HER2amp | Luminal | GSK461364 | PLK1 | PLK | 1.33 | uM | 7819.001 | 1.0187 | 1.0768 | 0.4919 | |
| HCC1419 | HER2amp | Luminal | GSK461364 | PLK1 | PLK | 6.67 | uM | 7819.001 | 0.9245 | 0.7050 | 0.4919 | |
| HCC1419 | HER2amp | Luminal | GSK461364 | PLK1 | PLK | 33.3 | uM | 7819.001 | 0.5520 | -0.4023 | 0.4919 | |
| HCC1419 | HER2amp | Luminal | GSK461364 | PLK1 | PLK | 0.0000853 | uM | 7820.001 | 1.0106 | 1.0275 | 0.7692 | |
| HCC1419 | HER2amp | Luminal | GSK461364 | PLK1 | PLK | 0.000427 | uM | 7820.001 | 1.0739 | 1.1942 | 0.7692 | |
| HCC1419 | HER2amp | Luminal | GSK461364 | PLK1 | PLK | 0.00213 | uM | 7820.001 | 1.0042 | 1.0109 | 0.7692 | |
| HCC1419 | HER2amp | Luminal | GSK461364 | PLK1 | PLK | 0.0107 | uM | 7820.001 | 0.9819 | 0.9530 | 0.7692 | |
| HCC1419 | HER2amp | Luminal | GSK461364 | PLK1 | PLK | 0.0533 | uM | 7820.001 | 0.9501 | 0.8711 | 0.7692 | |
| HCC1419 | HER2amp | Luminal | GSK461364 | PLK1 | PLK | 0.267 | uM | 7820.001 | 0.8389 | 0.5916 | 0.7692 | |
| HCC1419 | HER2amp | Luminal | GSK461364 | PLK1 | PLK | 1.33 | uM | 7820.001 | 1.0911 | 1.2401 | 0.7692 | |
| HCC1419 | HER2amp | Luminal | GSK461364 | PLK1 | PLK | 6.67 | uM | 7820.001 | 0.9198 | 0.7941 | 0.7692 | |
| HCC1419 | HER2amp | Luminal | GSK461364 | PLK1 | PLK | 33.3 | uM | 7820.001 | 0.2246 | -0.7130 | 0.7692 | |
| HCC1419 | HER2amp | Luminal | GSK461364 | PLK1 | PLK | 0.0000853 | uM | 7821.001 | 1.0121 | 1.0746 | 0.3296 | |
| HCC1419 | HER2amp | Luminal | GSK461364 | PLK1 | PLK | 0.000427 | uM | 7821.001 | 1.0196 | 1.1215 | 0.3296 | |
| HCC1419 | HER2amp | Luminal | GSK461364 | PLK1 | PLK | 0.00213 | uM | 7821.001 | 1.0373 | 1.2352 | 0.3296 | |
| HCC1419 | HER2amp | Luminal | GSK461364 | PLK1 | PLK | 0.0107 | uM | 7821.001 | 1.0691 | 1.4497 | 0.3296 | |
| HCC1419 | HER2amp | Luminal | GSK461364 | PLK1 | PLK | 0.0533 | uM | 7821.001 | 0.9614 | 0.7748 | 0.3296 | |
| HCC1419 | HER2amp | Luminal | GSK461364 | PLK1 | PLK | 0.267 | uM | 7821.001 | 0.9120 | 0.5124 | 0.3296 | |
| HCC1419 | HER2amp | Luminal | GSK461364 | PLK1 | PLK | 1.33 | uM | 7821.001 | 1.0363 | 1.2287 | 0.3296 | |
| HCC1419 | HER2amp | Luminal | GSK461364 | PLK1 | PLK | 6.67 | uM | 7821.001 | 0.9093 | 0.4989 | 0.3296 | |
| HCC1419 | HER2amp | Luminal | GSK461364 | PLK1 | PLK | 33.3 | uM | 7821.001 | 0.4652 | -0.8039 | 0.3296 |