Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
Download: Excel (XLSX), Comma-separated (CSV)
| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| ZR-75-1 | HR+ | Luminal | GSK1070916 | AURK | AURK | 0.00213 | uM | 9958.001 | 0.9771 | 0.9124 | 0.5164 | |
| ZR-75-1 | HR+ | Luminal | GSK1070916 | AURK | AURK | 0.0107 | uM | 9958.001 | 0.9149 | 0.6836 | 0.5164 | |
| ZR-75-1 | HR+ | Luminal | GSK1070916 | AURK | AURK | 0.0533 | uM | 9958.001 | 0.8695 | 0.5256 | 0.5164 | |
| ZR-75-1 | HR+ | Luminal | GSK1070916 | AURK | AURK | 0.267 | uM | 9958.001 | 0.8454 | 0.4446 | 0.5164 | |
| ZR-75-1 | HR+ | Luminal | GSK1070916 | AURK | AURK | 1.33 | uM | 9958.001 | 0.8546 | 0.4753 | 0.5164 | |
| ZR-75-1 | HR+ | Luminal | GSK1070916 | AURK | AURK | 6.67 | uM | 9958.001 | 0.8900 | 0.5959 | 0.5164 | |
| ZR-75-1 | HR+ | Luminal | GSK1070916 | AURK | AURK | 33.3 | uM | 9958.001 | 0.6622 | -0.0998 | 0.5164 | |
| ZR75B | HR+ | Luminal | GSK1070916 | AURK | AURK | 0.0000853 | uM | 9972.001 | 1.0410 | 1.0778 | 1.0521 | |
| ZR75B | HR+ | Luminal | GSK1070916 | AURK | AURK | 0.000427 | uM | 9972.001 | 1.0123 | 1.0234 | 1.0521 | |
| ZR75B | HR+ | Luminal | GSK1070916 | AURK | AURK | 0.00213 | uM | 9972.001 | 1.0159 | 1.0303 | 1.0521 | |
| ZR75B | HR+ | Luminal | GSK1070916 | AURK | AURK | 0.0107 | uM | 9972.001 | 0.8025 | 0.6226 | 1.0521 | |
| ZR75B | HR+ | Luminal | GSK1070916 | AURK | AURK | 0.0533 | uM | 9972.001 | 0.8397 | 0.6940 | 1.0521 | |
| ZR75B | HR+ | Luminal | GSK1070916 | AURK | AURK | 0.267 | uM | 9972.001 | 0.8230 | 0.6619 | 1.0521 | |
| ZR75B | HR+ | Luminal | GSK1070916 | AURK | AURK | 1.33 | uM | 9972.001 | 0.7028 | 0.4304 | 1.0521 | |
| ZR75B | HR+ | Luminal | GSK1070916 | AURK | AURK | 6.67 | uM | 9972.001 | 0.6450 | 0.3182 | 1.0521 | |
| ZR75B | HR+ | Luminal | GSK1070916 | AURK | AURK | 33.3 | uM | 9972.001 | 0.3661 | -0.2305 | 1.0521 | |
| ZR75B | HR+ | Luminal | GSK1070916 | AURK | AURK | 0.0000853 | uM | 9997.001 | 1.0477 | 1.0953 | 1.0003 | |
| ZR75B | HR+ | Luminal | GSK1070916 | AURK | AURK | 0.000427 | uM | 9997.001 | 0.9532 | 0.9064 | 1.0003 | |
| ZR75B | HR+ | Luminal | GSK1070916 | AURK | AURK | 0.00213 | uM | 9997.001 | 1.0320 | 1.0640 | 1.0003 | |
| ZR75B | HR+ | Luminal | GSK1070916 | AURK | AURK | 0.0107 | uM | 9997.001 | 0.8226 | 0.6452 | 1.0003 | |
| ZR75B | HR+ | Luminal | GSK1070916 | AURK | AURK | 0.0533 | uM | 9997.001 | 0.8438 | 0.6877 | 1.0003 | |
| ZR75B | HR+ | Luminal | GSK1070916 | AURK | AURK | 0.267 | uM | 9997.001 | 0.9169 | 0.8338 | 1.0003 | |
| ZR75B | HR+ | Luminal | GSK1070916 | AURK | AURK | 1.33 | uM | 9997.001 | 0.8666 | 0.7333 | 1.0003 | |
| ZR75B | HR+ | Luminal | GSK1070916 | AURK | AURK | 6.67 | uM | 9997.001 | 0.6723 | 0.3448 | 1.0003 | |
| ZR75B | HR+ | Luminal | GSK1070916 | AURK | AURK | 33.3 | uM | 9997.001 | 0.4697 | -0.0603 | 1.0003 |