Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| HCC1428 | HR+ | Luminal | GSK1070916 | AURK | AURK | 6.67 | uM | 10031.001 | 0.7886 | 0.5353 | 0.8981 | |
| HCC1428 | HR+ | Luminal | GSK1070916 | AURK | AURK | 33.3 | uM | 10031.001 | 0.1442 | -0.7686 | 0.8981 | |
| HCC1569 | HER2amp | Basal A | GSK1070916 | AURK | AURK | 0.0000853 | uM | 7825.001 | 1.0051 | 1.0063 | 1.5991 | |
| HCC1569 | HER2amp | Basal A | GSK1070916 | AURK | AURK | 0.000427 | uM | 7825.001 | 0.9915 | 0.9894 | 1.5991 | |
| HCC1569 | HER2amp | Basal A | GSK1070916 | AURK | AURK | 0.00213 | uM | 7825.001 | 0.9917 | 0.9897 | 1.5991 | |
| HCC1569 | HER2amp | Basal A | GSK1070916 | AURK | AURK | 0.0107 | uM | 7825.001 | 0.8982 | 0.8701 | 1.5991 | |
| HCC1569 | HER2amp | Basal A | GSK1070916 | AURK | AURK | 0.0533 | uM | 7825.001 | 0.7001 | 0.6002 | 1.5991 | |
| HCC1569 | HER2amp | Basal A | GSK1070916 | AURK | AURK | 0.267 | uM | 7825.001 | 0.6785 | 0.5692 | 1.5991 | |
| HCC1569 | HER2amp | Basal A | GSK1070916 | AURK | AURK | 1.33 | uM | 7825.001 | 0.6551 | 0.5351 | 1.5991 | |
| HCC1569 | HER2amp | Basal A | GSK1070916 | AURK | AURK | 6.67 | uM | 7825.001 | 0.3119 | -0.0347 | 1.5991 | |
| HCC1569 | HER2amp | Basal A | GSK1070916 | AURK | AURK | 33.3 | uM | 7825.001 | 0.0315 | -0.7698 | 1.5991 | |
| HCC1569 | HER2amp | Basal A | GSK1070916 | AURK | AURK | 0.0000853 | uM | 9347.001 | 1.0589 | 1.0778 | 1.5003 | |
| HCC1569 | HER2amp | Basal A | GSK1070916 | AURK | AURK | 0.000427 | uM | 9347.001 | 0.9551 | 0.9397 | 1.5003 | |
| HCC1569 | HER2amp | Basal A | GSK1070916 | AURK | AURK | 0.00213 | uM | 9347.001 | 1.0162 | 1.0215 | 1.5003 | |
| HCC1569 | HER2amp | Basal A | GSK1070916 | AURK | AURK | 0.0107 | uM | 9347.001 | 0.9388 | 0.9175 | 1.5003 | |
| HCC1569 | HER2amp | Basal A | GSK1070916 | AURK | AURK | 0.0533 | uM | 9347.001 | 0.7861 | 0.7036 | 1.5003 | |
| HCC1569 | HER2amp | Basal A | GSK1070916 | AURK | AURK | 0.267 | uM | 9347.001 | 0.7364 | 0.6309 | 1.5003 | |
| HCC1569 | HER2amp | Basal A | GSK1070916 | AURK | AURK | 1.33 | uM | 9347.001 | 0.7715 | 0.6824 | 1.5003 | |
| HCC1569 | HER2amp | Basal A | GSK1070916 | AURK | AURK | 6.67 | uM | 9347.001 | 0.4482 | 0.1715 | 1.5003 | |
| HCC1569 | HER2amp | Basal A | GSK1070916 | AURK | AURK | 33.3 | uM | 9347.001 | 0.1219 | -0.5083 | 1.5003 | |
| HCC1806 | TNBC | Basal A | GSK1070916 | AURK | AURK | 0.0000853 | uM | 9376.001 | 1.0247 | 1.0268 | 1.8315 | |
| HCC1806 | TNBC | Basal A | GSK1070916 | AURK | AURK | 0.000427 | uM | 9376.001 | 0.9324 | 0.9251 | 1.8315 | |
| HCC1806 | TNBC | Basal A | GSK1070916 | AURK | AURK | 0.00213 | uM | 9376.001 | 1.0354 | 1.0383 | 1.8315 | |
| HCC1806 | TNBC | Basal A | GSK1070916 | AURK | AURK | 0.0107 | uM | 9376.001 | 0.9092 | 0.8987 | 1.8315 | |
| HCC1806 | TNBC | Basal A | GSK1070916 | AURK | AURK | 0.0533 | uM | 9376.001 | 0.8954 | 0.8829 | 1.8315 |