Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| HCC1419 | HER2amp | Luminal | GSK1070916 | AURK | AURK | 0.0000853 | uM | 10019.001 | 0.9917 | 0.9582 | 0.3968 | |
| HCC1419 | HER2amp | Luminal | GSK1070916 | AURK | AURK | 0.000427 | uM | 10019.001 | 1.0095 | 1.0481 | 0.3968 | |
| HCC1419 | HER2amp | Luminal | GSK1070916 | AURK | AURK | 0.00213 | uM | 10019.001 | 1.0789 | 1.4216 | 0.3968 | |
| HCC1419 | HER2amp | Luminal | GSK1070916 | AURK | AURK | 0.0107 | uM | 10019.001 | 0.9507 | 0.7605 | 0.3968 | |
| HCC1419 | HER2amp | Luminal | GSK1070916 | AURK | AURK | 0.0533 | uM | 10019.001 | 1.0690 | 1.3661 | 0.3968 | |
| HCC1419 | HER2amp | Luminal | GSK1070916 | AURK | AURK | 0.267 | uM | 10019.001 | 0.9554 | 0.7825 | 0.3968 | |
| HCC1419 | HER2amp | Luminal | GSK1070916 | AURK | AURK | 1.33 | uM | 10019.001 | 1.0281 | 1.1449 | 0.3968 | |
| HCC1419 | HER2amp | Luminal | GSK1070916 | AURK | AURK | 6.67 | uM | 10019.001 | 0.8696 | 0.4063 | 0.3968 | |
| HCC1419 | HER2amp | Luminal | GSK1070916 | AURK | AURK | 33.3 | uM | 10019.001 | 0.5685 | -0.5182 | 0.3968 | |
| HCC1428 | HR+ | Luminal | GSK1070916 | AURK | AURK | 0.0000853 | uM | 9294.001 | 1.0099 | 1.0252 | 0.7859 | |
| HCC1428 | HR+ | Luminal | GSK1070916 | AURK | AURK | 0.000427 | uM | 9294.001 | 0.9916 | 0.9787 | 0.7859 | |
| HCC1428 | HR+ | Luminal | GSK1070916 | AURK | AURK | 0.00213 | uM | 9294.001 | 0.9910 | 0.9771 | 0.7859 | |
| HCC1428 | HR+ | Luminal | GSK1070916 | AURK | AURK | 0.0107 | uM | 9294.001 | 0.9715 | 0.9277 | 0.7859 | |
| HCC1428 | HR+ | Luminal | GSK1070916 | AURK | AURK | 0.0533 | uM | 9294.001 | 0.9315 | 0.8273 | 0.7859 | |
| HCC1428 | HR+ | Luminal | GSK1070916 | AURK | AURK | 0.267 | uM | 9294.001 | 0.8811 | 0.7025 | 0.7859 | |
| HCC1428 | HR+ | Luminal | GSK1070916 | AURK | AURK | 1.33 | uM | 9294.001 | 0.8007 | 0.5074 | 0.7859 | |
| HCC1428 | HR+ | Luminal | GSK1070916 | AURK | AURK | 6.67 | uM | 9294.001 | 0.5630 | -0.0372 | 0.7859 | |
| HCC1428 | HR+ | Luminal | GSK1070916 | AURK | AURK | 33.3 | uM | 9294.001 | 0.0527 | -0.9528 | 0.7859 | |
| HCC1428 | HR+ | Luminal | GSK1070916 | AURK | AURK | 0.0000853 | uM | 10031.001 | 1.0552 | 1.1234 | 0.8981 | |
| HCC1428 | HR+ | Luminal | GSK1070916 | AURK | AURK | 0.000427 | uM | 10031.001 | 0.9731 | 0.9402 | 0.8981 | |
| HCC1428 | HR+ | Luminal | GSK1070916 | AURK | AURK | 0.00213 | uM | 10031.001 | 1.0102 | 1.0227 | 0.8981 | |
| HCC1428 | HR+ | Luminal | GSK1070916 | AURK | AURK | 0.0107 | uM | 10031.001 | 0.9540 | 0.8978 | 0.8981 | |
| HCC1428 | HR+ | Luminal | GSK1070916 | AURK | AURK | 0.0533 | uM | 10031.001 | 0.9678 | 0.9284 | 0.8981 | |
| HCC1428 | HR+ | Luminal | GSK1070916 | AURK | AURK | 0.267 | uM | 10031.001 | 0.9466 | 0.8815 | 0.8981 | |
| HCC1428 | HR+ | Luminal | GSK1070916 | AURK | AURK | 1.33 | uM | 10031.001 | 0.8670 | 0.7062 | 0.8981 |