Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| HCC1428 | HR+ | Luminal | Gemcitabine | DNA replication | DNA replication | 0.0462 | uM | 9294.011 | 1.0065 | 1.0179 | 0.7255 | |
| HCC1428 | HR+ | Luminal | Gemcitabine | DNA replication | DNA replication | 0.231 | uM | 9294.011 | 0.9885 | 0.9683 | 0.7255 | |
| HCC1428 | HR+ | Luminal | Gemcitabine | DNA replication | DNA replication | 1.16 | uM | 9294.011 | 1.0388 | 1.1078 | 0.7255 | |
| HCC1428 | HR+ | Luminal | Gemcitabine | DNA replication | DNA replication | 5.78 | uM | 9294.011 | 1.0181 | 1.0501 | 0.7255 | |
| HCC1428 | HR+ | Luminal | Gemcitabine | DNA replication | DNA replication | 28.9 | uM | 9294.011 | 0.8294 | 0.5456 | 0.7255 | |
| HCC1428 | HR+ | Luminal | Gemcitabine | DNA replication | DNA replication | 144 | uM | 9294.011 | 0.7351 | 0.3087 | 0.7255 | |
| HCC1569 | HER2amp | Basal A | Gemcitabine | DNA replication | DNA replication | 0.00037 | uM | 7825.011 | 0.9090 | 0.9037 | 1.9334 | |
| HCC1569 | HER2amp | Basal A | Gemcitabine | DNA replication | DNA replication | 0.00185 | uM | 7825.011 | 0.8892 | 0.8821 | 1.9334 | |
| HCC1569 | HER2amp | Basal A | Gemcitabine | DNA replication | DNA replication | 0.00925 | uM | 7825.011 | 0.7738 | 0.7516 | 1.9334 | |
| HCC1569 | HER2amp | Basal A | Gemcitabine | DNA replication | DNA replication | 0.0462 | uM | 7825.011 | 0.6474 | 0.5972 | 1.9334 | |
| HCC1569 | HER2amp | Basal A | Gemcitabine | DNA replication | DNA replication | 0.231 | uM | 7825.011 | 0.6411 | 0.5891 | 1.9334 | |
| HCC1569 | HER2amp | Basal A | Gemcitabine | DNA replication | DNA replication | 1.16 | uM | 7825.011 | 0.5685 | 0.4934 | 1.9334 | |
| HCC1569 | HER2amp | Basal A | Gemcitabine | DNA replication | DNA replication | 5.78 | uM | 7825.011 | 0.4869 | 0.3784 | 1.9334 | |
| HCC1569 | HER2amp | Basal A | Gemcitabine | DNA replication | DNA replication | 28.9 | uM | 7825.011 | 0.4494 | 0.3224 | 1.9334 | |
| HCC1569 | HER2amp | Basal A | Gemcitabine | DNA replication | DNA replication | 144 | uM | 7825.011 | 0.4542 | 0.3296 | 1.9334 | |
| HCC1569 | HER2amp | Basal A | Gemcitabine | DNA replication | DNA replication | 0.00037 | uM | 9347.011 | 1.0134 | 1.0160 | 1.6648 | |
| HCC1569 | HER2amp | Basal A | Gemcitabine | DNA replication | DNA replication | 0.00185 | uM | 9347.011 | 0.9504 | 0.9398 | 1.6648 | |
| HCC1569 | HER2amp | Basal A | Gemcitabine | DNA replication | DNA replication | 0.00925 | uM | 9347.011 | 0.9681 | 0.9614 | 1.6648 | |
| HCC1569 | HER2amp | Basal A | Gemcitabine | DNA replication | DNA replication | 0.0462 | uM | 9347.011 | 0.7951 | 0.7426 | 1.6648 | |
| HCC1569 | HER2amp | Basal A | Gemcitabine | DNA replication | DNA replication | 0.231 | uM | 9347.011 | 0.7777 | 0.7197 | 1.6648 | |
| HCC1569 | HER2amp | Basal A | Gemcitabine | DNA replication | DNA replication | 1.16 | uM | 9347.011 | 0.7400 | 0.6691 | 1.6648 | |
| HCC1569 | HER2amp | Basal A | Gemcitabine | DNA replication | DNA replication | 5.78 | uM | 9347.011 | 0.6606 | 0.5592 | 1.6648 | |
| HCC1569 | HER2amp | Basal A | Gemcitabine | DNA replication | DNA replication | 28.9 | uM | 9347.011 | 0.6445 | 0.5362 | 1.6648 | |
| HCC1569 | HER2amp | Basal A | Gemcitabine | DNA replication | DNA replication | 144 | uM | 9347.011 | 0.5944 | 0.4633 | 1.6648 | |
| HCC1806 | TNBC | Basal A | Gemcitabine | DNA replication | DNA replication | 0.00037 | uM | 7829.011 | 1.0094 | 1.0100 | 1.8746 |