Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| MDA-MB-134-VI | HR+ | Luminal | Geldanamycin | HSP90 | HSP90 | 0.032 | uM | 10077.049 | 0.7298 | 0.1209 | 0.5440 | |
| MDA-MB-134-VI | HR+ | Luminal | Geldanamycin | HSP90 | HSP90 | 0.16 | uM | 10077.049 | 0.5453 | -0.3441 | 0.5440 | |
| MDA-MB-134-VI | HR+ | Luminal | Geldanamycin | HSP90 | HSP90 | 0.8 | uM | 10077.049 | 0.4235 | -0.5878 | 0.5440 | |
| MDA-MB-134-VI | HR+ | Luminal | Geldanamycin | HSP90 | HSP90 | 4 | uM | 10077.049 | 0.3662 | -0.6844 | 0.5440 | |
| MDA-MB-134-VI | HR+ | Luminal | Geldanamycin | HSP90 | HSP90 | 20 | uM | 10077.049 | 0.3529 | -0.7053 | 0.5440 | |
| MDA-MB-134-VI | HR+ | Luminal | Geldanamycin | HSP90 | HSP90 | 100 | uM | 10077.049 | 0.2847 | -0.8013 | 0.5440 | |
| MDA-MB-157 | TNBC | Basal B | Geldanamycin | HSP90 | HSP90 | 0.000256 | uM | 10093.012 | 0.7536 | 0.5100 | 1.0064 | |
| MDA-MB-157 | TNBC | Basal B | Geldanamycin | HSP90 | HSP90 | 0.00128 | uM | 10093.012 | 0.9425 | 0.8857 | 1.0064 | |
| MDA-MB-157 | TNBC | Basal B | Geldanamycin | HSP90 | HSP90 | 0.0064 | uM | 10093.012 | 0.7691 | 0.5407 | 1.0064 | |
| MDA-MB-157 | TNBC | Basal B | Geldanamycin | HSP90 | HSP90 | 0.032 | uM | 10093.012 | 0.3324 | -0.3305 | 1.0064 | |
| MDA-MB-157 | TNBC | Basal B | Geldanamycin | HSP90 | HSP90 | 0.16 | uM | 10093.012 | 0.4745 | -0.0466 | 1.0064 | |
| MDA-MB-157 | TNBC | Basal B | Geldanamycin | HSP90 | HSP90 | 0.8 | uM | 10093.012 | 0.3225 | -0.3504 | 1.0064 | |
| MDA-MB-157 | TNBC | Basal B | Geldanamycin | HSP90 | HSP90 | 4 | uM | 10093.012 | 0.2717 | -0.4520 | 1.0064 | |
| MDA-MB-157 | TNBC | Basal B | Geldanamycin | HSP90 | HSP90 | 20 | uM | 10093.012 | 0.4379 | -0.1197 | 1.0064 | |
| MDA-MB-157 | TNBC | Basal B | Geldanamycin | HSP90 | HSP90 | 100 | uM | 10093.012 | 0.3722 | -0.2509 | 1.0064 | |
| MDA-MB-175-VII | HR+ | Luminal | Geldanamycin | HSP90 | HSP90 | 0.000256 | uM | 7886.04 | 0.9753 | 0.9367 | 0.7771 | |
| MDA-MB-175-VII | HR+ | Luminal | Geldanamycin | HSP90 | HSP90 | 0.00128 | uM | 7886.04 | 1.0199 | 1.0513 | 0.7771 | |
| MDA-MB-175-VII | HR+ | Luminal | Geldanamycin | HSP90 | HSP90 | 0.0064 | uM | 7886.04 | 0.9775 | 0.9423 | 0.7771 | |
| MDA-MB-175-VII | HR+ | Luminal | Geldanamycin | HSP90 | HSP90 | 0.032 | uM | 7886.04 | 0.4600 | -0.2638 | 0.7771 | |
| MDA-MB-175-VII | HR+ | Luminal | Geldanamycin | HSP90 | HSP90 | 0.16 | uM | 7886.04 | 0.3115 | -0.5541 | 0.7771 | |
| MDA-MB-175-VII | HR+ | Luminal | Geldanamycin | HSP90 | HSP90 | 0.8 | uM | 7886.04 | 0.3304 | -0.5190 | 0.7771 | |
| MDA-MB-175-VII | HR+ | Luminal | Geldanamycin | HSP90 | HSP90 | 4 | uM | 7886.04 | 0.3135 | -0.5505 | 0.7771 | |
| MDA-MB-175-VII | HR+ | Luminal | Geldanamycin | HSP90 | HSP90 | 20 | uM | 7886.04 | 0.3051 | -0.5659 | 0.7771 | |
| MDA-MB-175-VII | HR+ | Luminal | Geldanamycin | HSP90 | HSP90 | 100 | uM | 7886.04 | 0.2944 | -0.5854 | 0.7771 | |
| MDA-MB-231 | TNBC | Basal B | Geldanamycin | HSP90 | HSP90 | 0.000256 | uM | 7892.012 | 1.0386 | 1.0320 | 2.3881 |