Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| MDA-MB-231 | TNBC | Basal B | Geldanamycin | HSP90 | HSP90 | 0.00128 | uM | 7892.012 | 0.9739 | 0.9780 | 2.3881 | |
| MDA-MB-231 | TNBC | Basal B | Geldanamycin | HSP90 | HSP90 | 0.0064 | uM | 7892.012 | 0.9808 | 0.9839 | 2.3881 | |
| MDA-MB-231 | TNBC | Basal B | Geldanamycin | HSP90 | HSP90 | 0.032 | uM | 7892.012 | 0.3223 | 0.2448 | 2.3881 | |
| MDA-MB-231 | TNBC | Basal B | Geldanamycin | HSP90 | HSP90 | 0.16 | uM | 7892.012 | 0.2205 | 0.0618 | 2.3881 | |
| MDA-MB-231 | TNBC | Basal B | Geldanamycin | HSP90 | HSP90 | 0.8 | uM | 7892.012 | 0.1994 | 0.0180 | 2.3881 | |
| MDA-MB-231 | TNBC | Basal B | Geldanamycin | HSP90 | HSP90 | 4 | uM | 7892.012 | 0.1909 | -0.0003 | 2.3881 | |
| MDA-MB-231 | TNBC | Basal B | Geldanamycin | HSP90 | HSP90 | 20 | uM | 7892.012 | 0.1892 | -0.0041 | 2.3881 | |
| MDA-MB-231 | TNBC | Basal B | Geldanamycin | HSP90 | HSP90 | 100 | uM | 7892.012 | 0.2035 | 0.0268 | 2.3881 | |
| MDA-MB-361 | HER2amp | Luminal | Geldanamycin | HSP90 | HSP90 | 0.000256 | uM | 7896.04 | 1.0440 | 1.0815 | 1.0776 | |
| MDA-MB-361 | HER2amp | Luminal | Geldanamycin | HSP90 | HSP90 | 0.00128 | uM | 7896.04 | 1.0287 | 1.0531 | 1.0776 | |
| MDA-MB-361 | HER2amp | Luminal | Geldanamycin | HSP90 | HSP90 | 0.0064 | uM | 7896.04 | 1.0588 | 1.1089 | 1.0776 | |
| MDA-MB-361 | HER2amp | Luminal | Geldanamycin | HSP90 | HSP90 | 0.032 | uM | 7896.04 | 0.9151 | 0.8420 | 1.0776 | |
| MDA-MB-361 | HER2amp | Luminal | Geldanamycin | HSP90 | HSP90 | 0.16 | uM | 7896.04 | 0.1648 | -0.6247 | 1.0776 | |
| MDA-MB-361 | HER2amp | Luminal | Geldanamycin | HSP90 | HSP90 | 0.8 | uM | 7896.04 | 0.1747 | -0.6038 | 1.0776 | |
| MDA-MB-361 | HER2amp | Luminal | Geldanamycin | HSP90 | HSP90 | 4 | uM | 7896.04 | 0.1671 | -0.6198 | 1.0776 | |
| MDA-MB-361 | HER2amp | Luminal | Geldanamycin | HSP90 | HSP90 | 20 | uM | 7896.04 | 0.1688 | -0.6162 | 1.0776 | |
| MDA-MB-361 | HER2amp | Luminal | Geldanamycin | HSP90 | HSP90 | 100 | uM | 7896.04 | 0.1693 | -0.6153 | 1.0776 | |
| MDA-MB-361 | HER2amp | Luminal | Geldanamycin | HSP90 | HSP90 | 0.000256 | uM | 9648.012 | 1.0993 | 1.3697 | 0.5579 | |
| MDA-MB-361 | HER2amp | Luminal | Geldanamycin | HSP90 | HSP90 | 0.00128 | uM | 9648.012 | 1.1018 | 1.3795 | 0.5579 | |
| MDA-MB-361 | HER2amp | Luminal | Geldanamycin | HSP90 | HSP90 | 0.0064 | uM | 9648.012 | 1.0587 | 1.2153 | 0.5579 | |
| MDA-MB-361 | HER2amp | Luminal | Geldanamycin | HSP90 | HSP90 | 0.032 | uM | 9648.012 | 0.1836 | -0.9042 | 0.5579 | |
| MDA-MB-361 | HER2amp | Luminal | Geldanamycin | HSP90 | HSP90 | 0.16 | uM | 9648.012 | 0.1492 | -0.9339 | 0.5579 | |
| MDA-MB-361 | HER2amp | Luminal | Geldanamycin | HSP90 | HSP90 | 0.8 | uM | 9648.012 | 0.1421 | -0.9394 | 0.5579 | |
| MDA-MB-361 | HER2amp | Luminal | Geldanamycin | HSP90 | HSP90 | 4 | uM | 9648.012 | 0.1511 | -0.9324 | 0.5579 | |
| MDA-MB-361 | HER2amp | Luminal | Geldanamycin | HSP90 | HSP90 | 20 | uM | 9648.012 | 0.1333 | -0.9460 | 0.5579 |