Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
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MDA-MB-134-VI | HR+ | Luminal | Gefitinib | EGFR | ErbB | 33.3 | uM | 10077.049 | 0.7984 | 0.3223 | 0.5440 | |
MDA-MB-157 | TNBC | Basal B | Gefitinib | EGFR | ErbB | 0.0000853 | uM | 7878.016 | 1.0187 | 1.0263 | 1.4153 | |
MDA-MB-157 | TNBC | Basal B | Gefitinib | EGFR | ErbB | 0.000427 | uM | 7878.016 | 1.0388 | 1.0545 | 1.4153 | |
MDA-MB-157 | TNBC | Basal B | Gefitinib | EGFR | ErbB | 0.00213 | uM | 7878.016 | 1.0251 | 1.0354 | 1.4153 | |
MDA-MB-157 | TNBC | Basal B | Gefitinib | EGFR | ErbB | 0.0107 | uM | 7878.016 | 1.1098 | 1.1528 | 1.4153 | |
MDA-MB-157 | TNBC | Basal B | Gefitinib | EGFR | ErbB | 0.0533 | uM | 7878.016 | 1.0811 | 1.1132 | 1.4153 | |
MDA-MB-157 | TNBC | Basal B | Gefitinib | EGFR | ErbB | 0.267 | uM | 7878.016 | 1.0504 | 1.0708 | 1.4153 | |
MDA-MB-157 | TNBC | Basal B | Gefitinib | EGFR | ErbB | 1.33 | uM | 7878.016 | 1.0231 | 1.0325 | 1.4153 | |
MDA-MB-157 | TNBC | Basal B | Gefitinib | EGFR | ErbB | 6.67 | uM | 7878.016 | 0.9701 | 0.9575 | 1.4153 | |
MDA-MB-157 | TNBC | Basal B | Gefitinib | EGFR | ErbB | 33.3 | uM | 7878.016 | 0.2620 | -0.2237 | 1.4153 | |
MDA-MB-157 | TNBC | Basal B | Gefitinib | EGFR | ErbB | 0.0000853 | uM | 7882.016 | 0.9570 | 0.9209 | 1.0905 | |
MDA-MB-157 | TNBC | Basal B | Gefitinib | EGFR | ErbB | 0.000427 | uM | 7882.016 | 0.9593 | 0.9252 | 1.0905 | |
MDA-MB-157 | TNBC | Basal B | Gefitinib | EGFR | ErbB | 0.00213 | uM | 7882.016 | 0.9039 | 0.8230 | 1.0905 | |
MDA-MB-157 | TNBC | Basal B | Gefitinib | EGFR | ErbB | 0.0107 | uM | 7882.016 | 0.9956 | 0.9918 | 1.0905 | |
MDA-MB-157 | TNBC | Basal B | Gefitinib | EGFR | ErbB | 0.0533 | uM | 7882.016 | 0.9680 | 0.9412 | 1.0905 | |
MDA-MB-157 | TNBC | Basal B | Gefitinib | EGFR | ErbB | 0.267 | uM | 7882.016 | 0.9690 | 0.9432 | 1.0905 | |
MDA-MB-157 | TNBC | Basal B | Gefitinib | EGFR | ErbB | 1.33 | uM | 7882.016 | 0.9660 | 0.9376 | 1.0905 | |
MDA-MB-157 | TNBC | Basal B | Gefitinib | EGFR | ErbB | 6.67 | uM | 7882.016 | 0.8919 | 0.8008 | 1.0905 | |
MDA-MB-157 | TNBC | Basal B | Gefitinib | EGFR | ErbB | 33.3 | uM | 7882.016 | 0.1939 | -0.5556 | 1.0905 | |
MDA-MB-175-VII | HR+ | Luminal | Gefitinib | EGFR | ErbB | 0.0000853 | uM | 7884.016 | 1.0494 | 1.2210 | 0.4603 | |
MDA-MB-175-VII | HR+ | Luminal | Gefitinib | EGFR | ErbB | 0.000427 | uM | 7884.016 | 1.0470 | 1.2098 | 0.4603 | |
MDA-MB-175-VII | HR+ | Luminal | Gefitinib | EGFR | ErbB | 0.00213 | uM | 7884.016 | 1.1177 | 1.5471 | 0.4603 | |
MDA-MB-175-VII | HR+ | Luminal | Gefitinib | EGFR | ErbB | 0.0107 | uM | 7884.016 | 1.0588 | 1.2644 | 0.4603 | |
MDA-MB-175-VII | HR+ | Luminal | Gefitinib | EGFR | ErbB | 0.0533 | uM | 7884.016 | 1.0388 | 1.1725 | 0.4603 | |
MDA-MB-175-VII | HR+ | Luminal | Gefitinib | EGFR | ErbB | 0.267 | uM | 7884.016 | 0.9614 | 0.8360 | 0.4603 |