Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| HCC1806 | TNBC | Basal A | 5-DFUR | TYMS | TYMS | 1.6 | uM | 12239.143 | 0.8899 | 0.8933 | 2.1267 | |
| HCC1806 | TNBC | Basal A | 5-DFUR | TYMS | TYMS | 8 | uM | 12239.143 | 0.8436 | 0.8462 | 2.1267 | |
| HCC1806 | TNBC | Basal A | 5-DFUR | TYMS | TYMS | 40 | uM | 12239.143 | 0.7121 | 0.7048 | 2.1267 | |
| HCC1806 | TNBC | Basal A | 5-DFUR | TYMS | TYMS | 200 | uM | 12239.143 | 0.4967 | 0.4393 | 2.1267 | |
| HCC1806 | TNBC | Basal A | 5-DFUR | TYMS | TYMS | 1000 | uM | 12239.143 | 0.3151 | 0.1619 | 2.1267 | |
| HCC1806 | TNBC | Basal A | 5-DFUR | TYMS | TYMS | 5000 | uM | 12239.143 | 0.1925 | -0.0785 | 2.1267 | |
| HCC1937 | TNBC | Basal A | 5-DFUR | TYMS | TYMS | 0.0128 | uM | 11849.143 | 0.9986 | 0.9978 | 1.3433 | |
| HCC1937 | TNBC | Basal A | 5-DFUR | TYMS | TYMS | 0.064 | uM | 11849.143 | 1.0198 | 1.0294 | 1.3433 | |
| HCC1937 | TNBC | Basal A | 5-DFUR | TYMS | TYMS | 0.32 | uM | 11849.143 | 1.0255 | 1.0378 | 1.3433 | |
| HCC1937 | TNBC | Basal A | 5-DFUR | TYMS | TYMS | 1.6 | uM | 11849.143 | 1.0374 | 1.0555 | 1.3433 | |
| HCC1937 | TNBC | Basal A | 5-DFUR | TYMS | TYMS | 8 | uM | 11849.143 | 1.0064 | 1.0095 | 1.3433 | |
| HCC1937 | TNBC | Basal A | 5-DFUR | TYMS | TYMS | 40 | uM | 11849.143 | 0.8893 | 0.8328 | 1.3433 | |
| HCC1937 | TNBC | Basal A | 5-DFUR | TYMS | TYMS | 200 | uM | 11849.143 | 0.8095 | 0.7088 | 1.3433 | |
| HCC1937 | TNBC | Basal A | 5-DFUR | TYMS | TYMS | 1000 | uM | 11849.143 | 0.5765 | 0.3272 | 1.3433 | |
| HCC1937 | TNBC | Basal A | 5-DFUR | TYMS | TYMS | 5000 | uM | 11849.143 | 0.4372 | 0.0804 | 1.3433 | |
| HCC1954 | HER2amp | Basal A | 5-DFUR | TYMS | TYMS | 0.0128 | uM | 11055.143 | 1.0096 | 1.0112 | 1.7215 | |
| HCC1954 | HER2amp | Basal A | 5-DFUR | TYMS | TYMS | 0.064 | uM | 11055.143 | 1.0036 | 1.0042 | 1.7215 | |
| HCC1954 | HER2amp | Basal A | 5-DFUR | TYMS | TYMS | 0.32 | uM | 11055.143 | 1.0219 | 1.0253 | 1.7215 | |
| HCC1954 | HER2amp | Basal A | 5-DFUR | TYMS | TYMS | 1.6 | uM | 11055.143 | 1.0039 | 1.0045 | 1.7215 | |
| HCC1954 | HER2amp | Basal A | 5-DFUR | TYMS | TYMS | 8 | uM | 11055.143 | 0.8976 | 0.8783 | 1.7215 | |
| HCC1954 | HER2amp | Basal A | 5-DFUR | TYMS | TYMS | 40 | uM | 11055.143 | 0.6970 | 0.6216 | 1.7215 | |
| HCC1954 | HER2amp | Basal A | 5-DFUR | TYMS | TYMS | 200 | uM | 11055.143 | 0.5563 | 0.4227 | 1.7215 | |
| HCC1954 | HER2amp | Basal A | 5-DFUR | TYMS | TYMS | 1000 | uM | 11055.143 | 0.3919 | 0.1608 | 1.7215 | |
| HCC1954 | HER2amp | Basal A | 5-DFUR | TYMS | TYMS | 5000 | uM | 11055.143 | 0.1812 | -0.2584 | 1.7215 | |
| HCC2185 | TNBC | Luminal | 5-DFUR | TYMS | TYMS | 0.0128 | uM | 10996.143 | 0.9593 | 0.7440 | 0.3034 |