Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| HCC1428 | HR+ | Luminal | 5-DFUR | TYMS | TYMS | 40 | uM | 11936.143 | 0.8475 | 0.6255 | 0.7979 | |
| HCC1428 | HR+ | Luminal | 5-DFUR | TYMS | TYMS | 200 | uM | 11936.143 | 0.7727 | 0.4476 | 0.7979 | |
| HCC1428 | HR+ | Luminal | 5-DFUR | TYMS | TYMS | 1000 | uM | 11936.143 | 0.6005 | 0.0555 | 0.7979 | |
| HCC1428 | HR+ | Luminal | 5-DFUR | TYMS | TYMS | 5000 | uM | 11936.143 | 0.1570 | -0.8036 | 0.7979 | |
| HCC1569 | HER2amp | Basal A | 5-DFUR | TYMS | TYMS | 0.0128 | uM | 10872.143 | 0.9712 | 0.9647 | 1.6364 | |
| HCC1569 | HER2amp | Basal A | 5-DFUR | TYMS | TYMS | 0.064 | uM | 10872.143 | 0.9280 | 0.9107 | 1.6364 | |
| HCC1569 | HER2amp | Basal A | 5-DFUR | TYMS | TYMS | 0.32 | uM | 10872.143 | 0.9615 | 0.9525 | 1.6364 | |
| HCC1569 | HER2amp | Basal A | 5-DFUR | TYMS | TYMS | 1.6 | uM | 10872.143 | 0.9760 | 0.9706 | 1.6364 | |
| HCC1569 | HER2amp | Basal A | 5-DFUR | TYMS | TYMS | 8 | uM | 10872.143 | 0.9335 | 0.9176 | 1.6364 | |
| HCC1569 | HER2amp | Basal A | 5-DFUR | TYMS | TYMS | 40 | uM | 10872.143 | 0.8044 | 0.7508 | 1.6364 | |
| HCC1569 | HER2amp | Basal A | 5-DFUR | TYMS | TYMS | 200 | uM | 10872.143 | 0.7101 | 0.6224 | 1.6364 | |
| HCC1569 | HER2amp | Basal A | 5-DFUR | TYMS | TYMS | 1000 | uM | 10872.143 | 0.5226 | 0.3452 | 1.6364 | |
| HCC1569 | HER2amp | Basal A | 5-DFUR | TYMS | TYMS | 5000 | uM | 10872.143 | 0.3623 | 0.0754 | 1.6364 | |
| HCC1569 | HER2amp | Basal A | 5-DFUR | TYMS | TYMS | 0.0128 | uM | 12523.143 | 1.0135 | 1.0278 | 0.9700 | |
| HCC1569 | HER2amp | Basal A | 5-DFUR | TYMS | TYMS | 0.064 | uM | 12523.143 | 1.0131 | 1.0271 | 0.9700 | |
| HCC1569 | HER2amp | Basal A | 5-DFUR | TYMS | TYMS | 0.32 | uM | 12523.143 | 0.9919 | 0.9832 | 0.9700 | |
| HCC1569 | HER2amp | Basal A | 5-DFUR | TYMS | TYMS | 1.6 | uM | 12523.143 | 0.9577 | 0.9128 | 0.9700 | |
| HCC1569 | HER2amp | Basal A | 5-DFUR | TYMS | TYMS | 8 | uM | 12523.143 | 0.9058 | 0.8061 | 0.9700 | |
| HCC1569 | HER2amp | Basal A | 5-DFUR | TYMS | TYMS | 40 | uM | 12523.143 | 0.8395 | 0.6700 | 0.9700 | |
| HCC1569 | HER2amp | Basal A | 5-DFUR | TYMS | TYMS | 200 | uM | 12523.143 | 0.8396 | 0.6701 | 0.9700 | |
| HCC1569 | HER2amp | Basal A | 5-DFUR | TYMS | TYMS | 1000 | uM | 12523.143 | 0.7677 | 0.5229 | 0.9700 | |
| HCC1569 | HER2amp | Basal A | 5-DFUR | TYMS | TYMS | 5000 | uM | 12523.143 | 0.5605 | 0.1011 | 0.9700 | |
| HCC1806 | TNBC | Basal A | 5-DFUR | TYMS | TYMS | 0.0128 | uM | 12239.143 | 0.8950 | 0.8983 | 2.1267 | |
| HCC1806 | TNBC | Basal A | 5-DFUR | TYMS | TYMS | 0.064 | uM | 12239.143 | 0.8501 | 0.8530 | 2.1267 | |
| HCC1806 | TNBC | Basal A | 5-DFUR | TYMS | TYMS | 0.32 | uM | 12239.143 | 0.8749 | 0.8782 | 2.1267 |