Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| HCC1395 | TNBC | Basal B | 5-DFUR | TYMS | TYMS | 1000 | uM | 12084.143 | 0.5621 | 0.3052 | 1.3499 | |
| HCC1395 | TNBC | Basal B | 5-DFUR | TYMS | TYMS | 5000 | uM | 12084.143 | 0.2927 | -0.1951 | 1.3499 | |
| HCC1419 | HER2amp | Luminal | 5-DFUR | TYMS | TYMS | 0.0128 | uM | 12001.143 | 0.9560 | 0.8591 | 0.6160 | |
| HCC1419 | HER2amp | Luminal | 5-DFUR | TYMS | TYMS | 0.064 | uM | 12001.143 | 0.9763 | 0.9236 | 0.6160 | |
| HCC1419 | HER2amp | Luminal | 5-DFUR | TYMS | TYMS | 0.32 | uM | 12001.143 | 0.9867 | 0.9571 | 0.6160 | |
| HCC1419 | HER2amp | Luminal | 5-DFUR | TYMS | TYMS | 1.6 | uM | 12001.143 | 0.9340 | 0.7903 | 0.6160 | |
| HCC1419 | HER2amp | Luminal | 5-DFUR | TYMS | TYMS | 8 | uM | 12001.143 | 0.9118 | 0.7215 | 0.6160 | |
| HCC1419 | HER2amp | Luminal | 5-DFUR | TYMS | TYMS | 40 | uM | 12001.143 | 0.9496 | 0.8389 | 0.6160 | |
| HCC1419 | HER2amp | Luminal | 5-DFUR | TYMS | TYMS | 200 | uM | 12001.143 | 0.8986 | 0.6813 | 0.6160 | |
| HCC1419 | HER2amp | Luminal | 5-DFUR | TYMS | TYMS | 1000 | uM | 12001.143 | 0.8998 | 0.6851 | 0.6160 | |
| HCC1419 | HER2amp | Luminal | 5-DFUR | TYMS | TYMS | 5000 | uM | 12001.143 | 0.7131 | 0.1551 | 0.6160 | |
| HCC1428 | HR+ | Luminal | 5-DFUR | TYMS | TYMS | 0.0128 | uM | 10693.143 | 0.9992 | 0.9978 | 0.7509 | |
| HCC1428 | HR+ | Luminal | 5-DFUR | TYMS | TYMS | 0.064 | uM | 10693.143 | 0.9771 | 0.9393 | 0.7509 | |
| HCC1428 | HR+ | Luminal | 5-DFUR | TYMS | TYMS | 0.32 | uM | 10693.143 | 0.9647 | 0.9066 | 0.7509 | |
| HCC1428 | HR+ | Luminal | 5-DFUR | TYMS | TYMS | 1.6 | uM | 10693.143 | 0.9300 | 0.8158 | 0.7509 | |
| HCC1428 | HR+ | Luminal | 5-DFUR | TYMS | TYMS | 8 | uM | 10693.143 | 0.8967 | 0.7297 | 0.7509 | |
| HCC1428 | HR+ | Luminal | 5-DFUR | TYMS | TYMS | 40 | uM | 10693.143 | 0.7677 | 0.4065 | 0.7509 | |
| HCC1428 | HR+ | Luminal | 5-DFUR | TYMS | TYMS | 200 | uM | 10693.143 | 0.6692 | 0.1714 | 0.7509 | |
| HCC1428 | HR+ | Luminal | 5-DFUR | TYMS | TYMS | 1000 | uM | 10693.143 | 0.4820 | -0.2433 | 0.7509 | |
| HCC1428 | HR+ | Luminal | 5-DFUR | TYMS | TYMS | 5000 | uM | 10693.143 | 0.2296 | -0.7181 | 0.7509 | |
| HCC1428 | HR+ | Luminal | 5-DFUR | TYMS | TYMS | 0.0128 | uM | 11936.143 | 0.9641 | 0.9103 | 0.7979 | |
| HCC1428 | HR+ | Luminal | 5-DFUR | TYMS | TYMS | 0.064 | uM | 11936.143 | 0.9529 | 0.8827 | 0.7979 | |
| HCC1428 | HR+ | Luminal | 5-DFUR | TYMS | TYMS | 0.32 | uM | 11936.143 | 0.9845 | 0.9611 | 0.7979 | |
| HCC1428 | HR+ | Luminal | 5-DFUR | TYMS | TYMS | 1.6 | uM | 11936.143 | 0.9165 | 0.7928 | 0.7979 | |
| HCC1428 | HR+ | Luminal | 5-DFUR | TYMS | TYMS | 8 | uM | 11936.143 | 0.9087 | 0.7739 | 0.7979 |