Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| BT-474 | HER2amp | Luminal | Gefitinib | EGFR | ErbB | 0.267 | uM | 9163.024 | 0.9446 | 0.8040 | 0.5524 | |
| BT-474 | HER2amp | Luminal | Gefitinib | EGFR | ErbB | 1.33 | uM | 9163.024 | 0.7376 | 0.1527 | 0.5524 | |
| BT-474 | HER2amp | Luminal | Gefitinib | EGFR | ErbB | 6.67 | uM | 9163.024 | 0.2916 | -0.7851 | 0.5524 | |
| BT-474 | HER2amp | Luminal | Gefitinib | EGFR | ErbB | 33.3 | uM | 9163.024 | 0.0091 | -0.9996 | 0.5524 | |
| BT-483 | HR+ | Luminal | Gefitinib | EGFR | ErbB | 0.0000853 | uM | 7801.016 | 0.9889 | 0.9464 | 0.4118 | |
| BT-483 | HR+ | Luminal | Gefitinib | EGFR | ErbB | 0.000427 | uM | 7801.016 | 1.0323 | 1.1605 | 0.4118 | |
| BT-483 | HR+ | Luminal | Gefitinib | EGFR | ErbB | 0.00213 | uM | 7801.016 | 1.0072 | 1.0350 | 0.4118 | |
| BT-483 | HR+ | Luminal | Gefitinib | EGFR | ErbB | 0.0107 | uM | 7801.016 | 1.0086 | 1.0418 | 0.4118 | |
| BT-483 | HR+ | Luminal | Gefitinib | EGFR | ErbB | 0.0533 | uM | 7801.016 | 1.0118 | 1.0577 | 0.4118 | |
| BT-483 | HR+ | Luminal | Gefitinib | EGFR | ErbB | 0.267 | uM | 7801.016 | 1.0094 | 1.0459 | 0.4118 | |
| BT-483 | HR+ | Luminal | Gefitinib | EGFR | ErbB | 1.33 | uM | 7801.016 | 0.9748 | 0.8798 | 0.4118 | |
| BT-483 | HR+ | Luminal | Gefitinib | EGFR | ErbB | 6.67 | uM | 7801.016 | 0.8580 | 0.3786 | 0.4118 | |
| BT-483 | HR+ | Luminal | Gefitinib | EGFR | ErbB | 33.3 | uM | 7801.016 | 0.6766 | -0.2255 | 0.4118 | |
| BT-483 | HR+ | Luminal | Gefitinib | EGFR | ErbB | 0.0000853 | uM | 9186.049 | 1.0901 | 1.2654 | 0.6923 | |
| BT-483 | HR+ | Luminal | Gefitinib | EGFR | ErbB | 0.000427 | uM | 9186.049 | 1.0156 | 1.0451 | 0.6923 | |
| BT-483 | HR+ | Luminal | Gefitinib | EGFR | ErbB | 0.00213 | uM | 9186.049 | 1.0724 | 1.2124 | 0.6923 | |
| BT-483 | HR+ | Luminal | Gefitinib | EGFR | ErbB | 0.0107 | uM | 9186.049 | 1.0577 | 1.1689 | 0.6923 | |
| BT-483 | HR+ | Luminal | Gefitinib | EGFR | ErbB | 0.0533 | uM | 9186.049 | 0.9925 | 0.9782 | 0.6923 | |
| BT-483 | HR+ | Luminal | Gefitinib | EGFR | ErbB | 0.267 | uM | 9186.049 | 1.0212 | 1.0617 | 0.6923 | |
| BT-483 | HR+ | Luminal | Gefitinib | EGFR | ErbB | 1.33 | uM | 9186.049 | 1.0511 | 1.1494 | 0.6923 | |
| BT-483 | HR+ | Luminal | Gefitinib | EGFR | ErbB | 6.67 | uM | 9186.049 | 1.0512 | 1.1496 | 0.6923 | |
| BT-483 | HR+ | Luminal | Gefitinib | EGFR | ErbB | 33.3 | uM | 9186.049 | 0.8601 | 0.6087 | 0.6923 | |
| BT-549 | TNBC | Basal B | Gefitinib | EGFR | ErbB | 0.0000853 | uM | 7803.016 | 1.0623 | 1.0432 | 2.8300 | |
| BT-549 | TNBC | Basal B | Gefitinib | EGFR | ErbB | 0.000427 | uM | 7803.016 | 0.9961 | 0.9972 | 2.8300 | |
| BT-549 | TNBC | Basal B | Gefitinib | EGFR | ErbB | 0.00213 | uM | 7803.016 | 0.9912 | 0.9938 | 2.8300 |