Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Hs 578T | TNBC | Basal B | FTase Inhibitor I | Ftase | MAPK | 6.67 | uM | 10694.154 | 0.9730 | 0.9764 | 2.3045 | |
| Hs 578T | TNBC | Basal B | FTase Inhibitor I | Ftase | MAPK | 33.3 | uM | 10694.154 | 0.9940 | 0.9948 | 2.3045 | |
| LY2 | HR+ | Luminal | FTase Inhibitor I | Ftase | MAPK | 0.000171 | uM | 12319.167 | 0.7964 | 0.6712 | 1.2676 | |
| LY2 | HR+ | Luminal | FTase Inhibitor I | Ftase | MAPK | 0.000853 | uM | 12319.167 | 0.8488 | 0.7574 | 1.2676 | |
| LY2 | HR+ | Luminal | FTase Inhibitor I | Ftase | MAPK | 0.00427 | uM | 12319.167 | 0.9902 | 0.9845 | 1.2676 | |
| LY2 | HR+ | Luminal | FTase Inhibitor I | Ftase | MAPK | 0.0213 | uM | 12319.167 | 0.7030 | 0.5146 | 1.2676 | |
| LY2 | HR+ | Luminal | FTase Inhibitor I | Ftase | MAPK | 0.107 | uM | 12319.167 | 0.8774 | 0.8039 | 1.2676 | |
| LY2 | HR+ | Luminal | FTase Inhibitor I | Ftase | MAPK | 0.533 | uM | 12319.167 | 0.7613 | 0.6128 | 1.2676 | |
| LY2 | HR+ | Luminal | FTase Inhibitor I | Ftase | MAPK | 2.67 | uM | 12319.167 | 0.8772 | 0.8035 | 1.2676 | |
| LY2 | HR+ | Luminal | FTase Inhibitor I | Ftase | MAPK | 13.3 | uM | 12319.167 | 0.9952 | 0.9924 | 1.2676 | |
| LY2 | HR+ | Luminal | FTase Inhibitor I | Ftase | MAPK | 66.7 | uM | 12319.167 | 0.7028 | 0.5142 | 1.2676 | |
| MB 157 | Unknown | Unknown | FTase Inhibitor I | Ftase | MAPK | 0.000171 | uM | 12580.167 | 0.9973 | 0.9976 | 2.1970 | |
| MB 157 | Unknown | Unknown | FTase Inhibitor I | Ftase | MAPK | 0.000853 | uM | 12580.167 | 0.9926 | 0.9932 | 2.1970 | |
| MB 157 | Unknown | Unknown | FTase Inhibitor I | Ftase | MAPK | 0.00427 | uM | 12580.167 | 1.0046 | 1.0041 | 2.1970 | |
| MB 157 | Unknown | Unknown | FTase Inhibitor I | Ftase | MAPK | 0.0213 | uM | 12580.167 | 0.9952 | 0.9956 | 2.1970 | |
| MB 157 | Unknown | Unknown | FTase Inhibitor I | Ftase | MAPK | 0.107 | uM | 12580.167 | 0.9921 | 0.9928 | 2.1970 | |
| MB 157 | Unknown | Unknown | FTase Inhibitor I | Ftase | MAPK | 0.533 | uM | 12580.167 | 1.0416 | 1.0374 | 2.1970 | |
| MB 157 | Unknown | Unknown | FTase Inhibitor I | Ftase | MAPK | 2.67 | uM | 12580.167 | 1.0458 | 1.0412 | 2.1970 | |
| MB 157 | Unknown | Unknown | FTase Inhibitor I | Ftase | MAPK | 13.3 | uM | 12580.167 | 1.0258 | 1.0233 | 2.1970 | |
| MB 157 | Unknown | Unknown | FTase Inhibitor I | Ftase | MAPK | 66.7 | uM | 12580.167 | 1.0286 | 1.0259 | 2.1970 | |
| MCF 10A | NM | Basal B | FTase Inhibitor I | Ftase | MAPK | 0.0000853 | uM | 11056.154 | 0.9079 | 0.9352 | 2.9341 | |
| MCF 10A | NM | Basal B | FTase Inhibitor I | Ftase | MAPK | 0.000427 | uM | 11056.154 | 0.9988 | 0.9992 | 2.9341 | |
| MCF 10A | NM | Basal B | FTase Inhibitor I | Ftase | MAPK | 0.00213 | uM | 11056.154 | 0.9405 | 0.9586 | 2.9341 | |
| MCF 10A | NM | Basal B | FTase Inhibitor I | Ftase | MAPK | 0.0107 | uM | 11056.154 | 0.9305 | 0.9515 | 2.9341 | |
| MCF 10A | NM | Basal B | FTase Inhibitor I | Ftase | MAPK | 0.0533 | uM | 11056.154 | 0.9538 | 0.9680 | 2.9341 |