Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SUM229PE | TNBC | - | FR180204 | ERK1/2 | MAPK | 0.267 | uM | 11058.149 | 0.9413 | 0.9454 | 2.1834 | |
| SUM229PE | TNBC | - | FR180204 | ERK1/2 | MAPK | 1.33 | uM | 11058.149 | 0.9601 | 0.9631 | 2.1834 | |
| SUM229PE | TNBC | - | FR180204 | ERK1/2 | MAPK | 6.67 | uM | 11058.149 | 0.8549 | 0.8614 | 2.1834 | |
| SUM229PE | TNBC | - | FR180204 | ERK1/2 | MAPK | 33.3 | uM | 11058.149 | 0.6878 | 0.6850 | 2.1834 | |
| SUM52PE | HR+ | Luminal | FR180204 | ERK1/2 | MAPK | 0.0000853 | uM | 10695.149 | 1.0014 | 1.0020 | 1.3252 | |
| SUM52PE | HR+ | Luminal | FR180204 | ERK1/2 | MAPK | 0.000427 | uM | 10695.149 | 1.0275 | 1.0413 | 1.3252 | |
| SUM52PE | HR+ | Luminal | FR180204 | ERK1/2 | MAPK | 0.00213 | uM | 10695.149 | 0.9234 | 0.8833 | 1.3252 | |
| SUM52PE | HR+ | Luminal | FR180204 | ERK1/2 | MAPK | 0.0107 | uM | 10695.149 | 0.9751 | 0.9622 | 1.3252 | |
| SUM52PE | HR+ | Luminal | FR180204 | ERK1/2 | MAPK | 0.0533 | uM | 10695.149 | 1.0253 | 1.0381 | 1.3252 | |
| SUM52PE | HR+ | Luminal | FR180204 | ERK1/2 | MAPK | 0.267 | uM | 10695.149 | 1.0021 | 1.0032 | 1.3252 | |
| SUM52PE | HR+ | Luminal | FR180204 | ERK1/2 | MAPK | 1.33 | uM | 10695.149 | 0.9835 | 0.9750 | 1.3252 | |
| SUM52PE | HR+ | Luminal | FR180204 | ERK1/2 | MAPK | 6.67 | uM | 10695.149 | 0.9387 | 0.9067 | 1.3252 | |
| SUM52PE | HR+ | Luminal | FR180204 | ERK1/2 | MAPK | 33.3 | uM | 10695.149 | 0.7904 | 0.6748 | 1.3252 | |
| SUM52PE | HR+ | Luminal | FR180204 | ERK1/2 | MAPK | 0.000256 | uM | 11852.161 | 1.0571 | 1.0721 | 1.5680 | |
| SUM52PE | HR+ | Luminal | FR180204 | ERK1/2 | MAPK | 0.00128 | uM | 11852.161 | 1.0278 | 1.0352 | 1.5680 | |
| SUM52PE | HR+ | Luminal | FR180204 | ERK1/2 | MAPK | 0.0064 | uM | 11852.161 | 0.9805 | 0.9750 | 1.5680 | |
| SUM52PE | HR+ | Luminal | FR180204 | ERK1/2 | MAPK | 0.032 | uM | 11852.161 | 0.9665 | 0.9570 | 1.5680 | |
| SUM52PE | HR+ | Luminal | FR180204 | ERK1/2 | MAPK | 0.16 | uM | 11852.161 | 1.0302 | 1.0383 | 1.5680 | |
| SUM52PE | HR+ | Luminal | FR180204 | ERK1/2 | MAPK | 0.8 | uM | 11852.161 | 0.9241 | 0.9019 | 1.5680 | |
| SUM52PE | HR+ | Luminal | FR180204 | ERK1/2 | MAPK | 4 | uM | 11852.161 | 0.9931 | 0.9912 | 1.5680 | |
| SUM52PE | HR+ | Luminal | FR180204 | ERK1/2 | MAPK | 20 | uM | 11852.161 | 0.8043 | 0.7407 | 1.5680 | |
| SUM52PE | HR+ | Luminal | FR180204 | ERK1/2 | MAPK | 100 | uM | 11852.161 | 0.5081 | 0.2988 | 1.5680 | |
| T47D | HR+ | Luminal | FR180204 | ERK1/2 | MAPK | 0.0000853 | uM | 10939.149 | 0.9381 | 0.9251 | 1.6748 | |
| T47D | HR+ | Luminal | FR180204 | ERK1/2 | MAPK | 0.000427 | uM | 10939.149 | 0.9820 | 0.9784 | 1.6748 | |
| T47D | HR+ | Luminal | FR180204 | ERK1/2 | MAPK | 0.00213 | uM | 10939.149 | 0.9590 | 0.9507 | 1.6748 |