Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SUM159PT | TNBC | Basal B | FR180204 | ERK1/2 | MAPK | 6.67 | uM | 11057.149 | 0.8349 | 0.9139 | 4.1019 | |
| SUM159PT | TNBC | Basal B | FR180204 | ERK1/2 | MAPK | 33.3 | uM | 11057.149 | 0.6105 | 0.7733 | 4.1019 | |
| SUM225CWN | HER2amp | Basal A | FR180204 | ERK1/2 | MAPK | 0.0000853 | uM | 10579.137 | 1.0050 | 1.0110 | 0.9202 | |
| SUM225CWN | HER2amp | Basal A | FR180204 | ERK1/2 | MAPK | 0.000427 | uM | 10579.137 | 0.9587 | 0.9104 | 0.9202 | |
| SUM225CWN | HER2amp | Basal A | FR180204 | ERK1/2 | MAPK | 0.00213 | uM | 10579.137 | 0.9760 | 0.9478 | 0.9202 | |
| SUM225CWN | HER2amp | Basal A | FR180204 | ERK1/2 | MAPK | 0.0107 | uM | 10579.137 | 1.0642 | 1.1398 | 0.9202 | |
| SUM225CWN | HER2amp | Basal A | FR180204 | ERK1/2 | MAPK | 0.0533 | uM | 10579.137 | 1.0518 | 1.1128 | 0.9202 | |
| SUM225CWN | HER2amp | Basal A | FR180204 | ERK1/2 | MAPK | 0.267 | uM | 10579.137 | 1.0450 | 1.0980 | 0.9202 | |
| SUM225CWN | HER2amp | Basal A | FR180204 | ERK1/2 | MAPK | 1.33 | uM | 10579.137 | 1.0728 | 1.1587 | 0.9202 | |
| SUM225CWN | HER2amp | Basal A | FR180204 | ERK1/2 | MAPK | 6.67 | uM | 10579.137 | 0.9369 | 0.8633 | 0.9202 | |
| SUM225CWN | HER2amp | Basal A | FR180204 | ERK1/2 | MAPK | 33.3 | uM | 10579.137 | 0.8062 | 0.5826 | 0.9202 | |
| SUM225CWN | HER2amp | Basal A | FR180204 | ERK1/2 | MAPK | 0.000256 | uM | 12098.161 | 0.8749 | 0.8203 | 1.4196 | |
| SUM225CWN | HER2amp | Basal A | FR180204 | ERK1/2 | MAPK | 0.00128 | uM | 12098.161 | 0.8730 | 0.8175 | 1.4196 | |
| SUM225CWN | HER2amp | Basal A | FR180204 | ERK1/2 | MAPK | 0.0064 | uM | 12098.161 | 0.8988 | 0.8552 | 1.4196 | |
| SUM225CWN | HER2amp | Basal A | FR180204 | ERK1/2 | MAPK | 0.032 | uM | 12098.161 | 0.8987 | 0.8550 | 1.4196 | |
| SUM225CWN | HER2amp | Basal A | FR180204 | ERK1/2 | MAPK | 0.16 | uM | 12098.161 | 0.9399 | 0.9145 | 1.4196 | |
| SUM225CWN | HER2amp | Basal A | FR180204 | ERK1/2 | MAPK | 0.8 | uM | 12098.161 | 0.8909 | 0.8436 | 1.4196 | |
| SUM225CWN | HER2amp | Basal A | FR180204 | ERK1/2 | MAPK | 4 | uM | 12098.161 | 1.0043 | 1.0061 | 1.4196 | |
| SUM225CWN | HER2amp | Basal A | FR180204 | ERK1/2 | MAPK | 20 | uM | 12098.161 | 0.7900 | 0.6940 | 1.4196 | |
| SUM225CWN | HER2amp | Basal A | FR180204 | ERK1/2 | MAPK | 100 | uM | 12098.161 | 0.6543 | 0.4834 | 1.4196 | |
| SUM229PE | TNBC | - | FR180204 | ERK1/2 | MAPK | 0.0000853 | uM | 11058.149 | 0.9172 | 0.9224 | 2.1834 | |
| SUM229PE | TNBC | - | FR180204 | ERK1/2 | MAPK | 0.000427 | uM | 11058.149 | 1.0258 | 1.0235 | 2.1834 | |
| SUM229PE | TNBC | - | FR180204 | ERK1/2 | MAPK | 0.00213 | uM | 11058.149 | 0.9460 | 0.9498 | 2.1834 | |
| SUM229PE | TNBC | - | FR180204 | ERK1/2 | MAPK | 0.0107 | uM | 11058.149 | 0.9559 | 0.9591 | 2.1834 | |
| SUM229PE | TNBC | - | FR180204 | ERK1/2 | MAPK | 0.0533 | uM | 11058.149 | 0.9495 | 0.9531 | 2.1834 |