Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| MX1 | Unknown | Unknown | FR180204 | ERK1/2 | MAPK | 0.0533 | uM | 10874.149 | 0.9618 | 0.9077 | 0.8239 | |
| MX1 | Unknown | Unknown | FR180204 | ERK1/2 | MAPK | 0.267 | uM | 10874.149 | 0.9763 | 0.9426 | 0.8239 | |
| MX1 | Unknown | Unknown | FR180204 | ERK1/2 | MAPK | 1.33 | uM | 10874.149 | 0.9661 | 0.9181 | 0.8239 | |
| MX1 | Unknown | Unknown | FR180204 | ERK1/2 | MAPK | 6.67 | uM | 10874.149 | 1.0020 | 1.0048 | 0.8239 | |
| MX1 | Unknown | Unknown | FR180204 | ERK1/2 | MAPK | 33.3 | uM | 10874.149 | 0.9708 | 0.9293 | 0.8239 | |
| MX1 | Unknown | Unknown | FR180204 | ERK1/2 | MAPK | 0.000256 | uM | 12220.161 | 0.9143 | 0.6519 | 0.4684 | |
| MX1 | Unknown | Unknown | FR180204 | ERK1/2 | MAPK | 0.00128 | uM | 12220.161 | 0.9531 | 0.8051 | 0.4684 | |
| MX1 | Unknown | Unknown | FR180204 | ERK1/2 | MAPK | 0.0064 | uM | 12220.161 | 0.9461 | 0.7769 | 0.4684 | |
| MX1 | Unknown | Unknown | FR180204 | ERK1/2 | MAPK | 0.032 | uM | 12220.161 | 0.9625 | 0.8432 | 0.4684 | |
| MX1 | Unknown | Unknown | FR180204 | ERK1/2 | MAPK | 0.16 | uM | 12220.161 | 0.9382 | 0.7454 | 0.4684 | |
| MX1 | Unknown | Unknown | FR180204 | ERK1/2 | MAPK | 0.8 | uM | 12220.161 | 0.9213 | 0.6790 | 0.4684 | |
| MX1 | Unknown | Unknown | FR180204 | ERK1/2 | MAPK | 4 | uM | 12220.161 | 1.0199 | 1.0861 | 0.4684 | |
| MX1 | Unknown | Unknown | FR180204 | ERK1/2 | MAPK | 20 | uM | 12220.161 | 1.0103 | 1.0441 | 0.4684 | |
| MX1 | Unknown | Unknown | FR180204 | ERK1/2 | MAPK | 100 | uM | 12220.161 | 0.6654 | -0.1619 | 0.4684 | |
| SK-BR-3 | HER2amp | Luminal | FR180204 | ERK1/2 | MAPK | 0.000256 | uM | 11851.161 | 1.0280 | 1.0384 | 1.4516 | |
| SK-BR-3 | HER2amp | Luminal | FR180204 | ERK1/2 | MAPK | 0.00128 | uM | 11851.161 | 0.9574 | 0.9409 | 1.4516 | |
| SK-BR-3 | HER2amp | Luminal | FR180204 | ERK1/2 | MAPK | 0.0064 | uM | 11851.161 | 0.9529 | 0.9346 | 1.4516 | |
| SK-BR-3 | HER2amp | Luminal | FR180204 | ERK1/2 | MAPK | 0.032 | uM | 11851.161 | 1.0068 | 1.0093 | 1.4516 | |
| SK-BR-3 | HER2amp | Luminal | FR180204 | ERK1/2 | MAPK | 0.16 | uM | 11851.161 | 1.0018 | 1.0025 | 1.4516 | |
| SK-BR-3 | HER2amp | Luminal | FR180204 | ERK1/2 | MAPK | 0.8 | uM | 11851.161 | 0.9195 | 0.8877 | 1.4516 | |
| SK-BR-3 | HER2amp | Luminal | FR180204 | ERK1/2 | MAPK | 4 | uM | 11851.161 | 0.9906 | 0.9870 | 1.4516 | |
| SK-BR-3 | HER2amp | Luminal | FR180204 | ERK1/2 | MAPK | 20 | uM | 11851.161 | 0.9192 | 0.8873 | 1.4516 | |
| SK-BR-3 | HER2amp | Luminal | FR180204 | ERK1/2 | MAPK | 100 | uM | 11851.161 | 0.7553 | 0.6484 | 1.4516 | |
| SUM1315MO2 | TNBC | Basal B | FR180204 | ERK1/2 | MAPK | 0.0000853 | uM | 10875.149 | 0.9901 | 0.9735 | 0.7469 | |
| SUM1315MO2 | TNBC | Basal B | FR180204 | ERK1/2 | MAPK | 0.000427 | uM | 10875.149 | 1.0443 | 1.1196 | 0.7469 |