Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
Download: Excel (XLSX), Comma-separated (CSV)
| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| MDA-MB-415 | HR+ | Luminal | FR180204 | ERK1/2 | MAPK | 4 | uM | 12333.166 | 0.9728 | 0.9152 | 0.6353 | |
| MDA-MB-415 | HR+ | Luminal | FR180204 | ERK1/2 | MAPK | 20 | uM | 12333.166 | 0.9834 | 0.9479 | 0.6353 | |
| MDA-MB-415 | HR+ | Luminal | FR180204 | ERK1/2 | MAPK | 100 | uM | 12333.166 | 0.9135 | 0.7346 | 0.6353 | |
| MDA-MB-453 | TNBC | Luminal | FR180204 | ERK1/2 | MAPK | 0.000256 | uM | 12414.166 | 0.9037 | 0.8512 | 1.3106 | |
| MDA-MB-453 | TNBC | Luminal | FR180204 | ERK1/2 | MAPK | 0.00128 | uM | 12414.166 | 0.9670 | 0.9494 | 1.3106 | |
| MDA-MB-453 | TNBC | Luminal | FR180204 | ERK1/2 | MAPK | 0.0064 | uM | 12414.166 | 0.9418 | 0.9106 | 1.3106 | |
| MDA-MB-453 | TNBC | Luminal | FR180204 | ERK1/2 | MAPK | 0.032 | uM | 12414.166 | 0.8961 | 0.8394 | 1.3106 | |
| MDA-MB-453 | TNBC | Luminal | FR180204 | ERK1/2 | MAPK | 0.16 | uM | 12414.166 | 0.9909 | 0.9861 | 1.3106 | |
| MDA-MB-453 | TNBC | Luminal | FR180204 | ERK1/2 | MAPK | 0.8 | uM | 12414.166 | 0.9289 | 0.8906 | 1.3106 | |
| MDA-MB-453 | TNBC | Luminal | FR180204 | ERK1/2 | MAPK | 4 | uM | 12414.166 | 0.8909 | 0.8313 | 1.3106 | |
| MDA-MB-453 | TNBC | Luminal | FR180204 | ERK1/2 | MAPK | 20 | uM | 12414.166 | 0.9024 | 0.8493 | 1.3106 | |
| MDA-MB-453 | TNBC | Luminal | FR180204 | ERK1/2 | MAPK | 100 | uM | 12414.166 | 0.8089 | 0.7012 | 1.3106 | |
| MX1 | Unknown | Unknown | FR180204 | ERK1/2 | MAPK | 0.0000853 | uM | 10644.137 | 0.9668 | 0.8873 | 0.5827 | |
| MX1 | Unknown | Unknown | FR180204 | ERK1/2 | MAPK | 0.000427 | uM | 10644.137 | 0.9483 | 0.8259 | 0.5827 | |
| MX1 | Unknown | Unknown | FR180204 | ERK1/2 | MAPK | 0.00213 | uM | 10644.137 | 0.9647 | 0.8803 | 0.5827 | |
| MX1 | Unknown | Unknown | FR180204 | ERK1/2 | MAPK | 0.0107 | uM | 10644.137 | 1.0140 | 1.0481 | 0.5827 | |
| MX1 | Unknown | Unknown | FR180204 | ERK1/2 | MAPK | 0.0533 | uM | 10644.137 | 1.0007 | 1.0023 | 0.5827 | |
| MX1 | Unknown | Unknown | FR180204 | ERK1/2 | MAPK | 0.267 | uM | 10644.137 | 0.9692 | 0.8956 | 0.5827 | |
| MX1 | Unknown | Unknown | FR180204 | ERK1/2 | MAPK | 1.33 | uM | 10644.137 | 1.0121 | 1.0416 | 0.5827 | |
| MX1 | Unknown | Unknown | FR180204 | ERK1/2 | MAPK | 6.67 | uM | 10644.137 | 0.9794 | 0.9297 | 0.5827 | |
| MX1 | Unknown | Unknown | FR180204 | ERK1/2 | MAPK | 33.3 | uM | 10644.137 | 0.9339 | 0.7785 | 0.5827 | |
| MX1 | Unknown | Unknown | FR180204 | ERK1/2 | MAPK | 0.0000853 | uM | 10874.149 | 0.9473 | 0.8727 | 0.8239 | |
| MX1 | Unknown | Unknown | FR180204 | ERK1/2 | MAPK | 0.000427 | uM | 10874.149 | 1.0385 | 1.0938 | 0.8239 | |
| MX1 | Unknown | Unknown | FR180204 | ERK1/2 | MAPK | 0.00213 | uM | 10874.149 | 0.9910 | 0.9783 | 0.8239 | |
| MX1 | Unknown | Unknown | FR180204 | ERK1/2 | MAPK | 0.0107 | uM | 10874.149 | 0.9463 | 0.8704 | 0.8239 |