Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| HCC1954 | HER2amp | Basal A | FR180204 | ERK1/2 | MAPK | 33.3 | uM | 11055.149 | 0.8390 | 0.8007 | 1.6723 | |
| HCC2185 | TNBC | Luminal | FR180204 | ERK1/2 | MAPK | 0.0000853 | uM | 10996.149 | 0.9893 | 0.9554 | 0.4765 | |
| HCC2185 | TNBC | Luminal | FR180204 | ERK1/2 | MAPK | 0.000427 | uM | 10996.149 | 1.0812 | 1.3562 | 0.4765 | |
| HCC2185 | TNBC | Luminal | FR180204 | ERK1/2 | MAPK | 0.00213 | uM | 10996.149 | 0.9957 | 0.9822 | 0.4765 | |
| HCC2185 | TNBC | Luminal | FR180204 | ERK1/2 | MAPK | 0.0107 | uM | 10996.149 | 0.9810 | 0.9210 | 0.4765 | |
| HCC2185 | TNBC | Luminal | FR180204 | ERK1/2 | MAPK | 0.0533 | uM | 10996.149 | 1.0120 | 1.0509 | 0.4765 | |
| HCC2185 | TNBC | Luminal | FR180204 | ERK1/2 | MAPK | 0.267 | uM | 10996.149 | 0.9711 | 0.8804 | 0.4765 | |
| HCC2185 | TNBC | Luminal | FR180204 | ERK1/2 | MAPK | 1.33 | uM | 10996.149 | 0.9940 | 0.9750 | 0.4765 | |
| HCC2185 | TNBC | Luminal | FR180204 | ERK1/2 | MAPK | 6.67 | uM | 10996.149 | 0.9934 | 0.9724 | 0.4765 | |
| HCC2185 | TNBC | Luminal | FR180204 | ERK1/2 | MAPK | 33.3 | uM | 10996.149 | 1.0936 | 1.4133 | 0.4765 | |
| HCC2185 | TNBC | Luminal | FR180204 | ERK1/2 | MAPK | 0.000256 | uM | 12192.161 | 1.0167 | 1.0604 | 0.5555 | |
| HCC2185 | TNBC | Luminal | FR180204 | ERK1/2 | MAPK | 0.00128 | uM | 12192.161 | 1.0057 | 1.0205 | 0.5555 | |
| HCC2185 | TNBC | Luminal | FR180204 | ERK1/2 | MAPK | 0.0064 | uM | 12192.161 | 0.9591 | 0.8550 | 0.5555 | |
| HCC2185 | TNBC | Luminal | FR180204 | ERK1/2 | MAPK | 0.032 | uM | 12192.161 | 1.0364 | 1.1329 | 0.5555 | |
| HCC2185 | TNBC | Luminal | FR180204 | ERK1/2 | MAPK | 0.16 | uM | 12192.161 | 1.0650 | 1.2402 | 0.5555 | |
| HCC2185 | TNBC | Luminal | FR180204 | ERK1/2 | MAPK | 0.8 | uM | 12192.161 | 0.9970 | 0.9892 | 0.5555 | |
| HCC2185 | TNBC | Luminal | FR180204 | ERK1/2 | MAPK | 4 | uM | 12192.161 | 1.0703 | 1.2603 | 0.5555 | |
| HCC2185 | TNBC | Luminal | FR180204 | ERK1/2 | MAPK | 20 | uM | 12192.161 | 0.9435 | 0.8011 | 0.5555 | |
| HCC2185 | TNBC | Luminal | FR180204 | ERK1/2 | MAPK | 100 | uM | 12192.161 | 0.9682 | 0.8870 | 0.5555 | |
| HCC3153 | TNBC | Basal A | FR180204 | ERK1/2 | MAPK | 0.0000853 | uM | 10577.137 | 0.9603 | 0.9178 | 0.9653 | |
| HCC3153 | TNBC | Basal A | FR180204 | ERK1/2 | MAPK | 0.000427 | uM | 10577.137 | 0.9794 | 0.9573 | 0.9653 | |
| HCC3153 | TNBC | Basal A | FR180204 | ERK1/2 | MAPK | 0.00213 | uM | 10577.137 | 1.0198 | 1.0411 | 0.9653 | |
| HCC3153 | TNBC | Basal A | FR180204 | ERK1/2 | MAPK | 0.0107 | uM | 10577.137 | 1.0208 | 1.0431 | 0.9653 | |
| HCC3153 | TNBC | Basal A | FR180204 | ERK1/2 | MAPK | 0.0533 | uM | 10577.137 | 1.0581 | 1.1205 | 0.9653 | |
| HCC3153 | TNBC | Basal A | FR180204 | ERK1/2 | MAPK | 0.267 | uM | 10577.137 | 1.0369 | 1.0764 | 0.9653 |