Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| HCC1395 | TNBC | Basal B | Geldanamycin | HSP90 | HSP90 | 0.16 | uM | 9258.024 | 0.6861 | -0.0240 | 0.5251 | |
| HCC1395 | TNBC | Basal B | Geldanamycin | HSP90 | HSP90 | 0.8 | uM | 9258.024 | 0.5910 | -0.2654 | 0.5251 | |
| HCC1395 | TNBC | Basal B | Geldanamycin | HSP90 | HSP90 | 4 | uM | 9258.024 | 0.5416 | -0.3780 | 0.5251 | |
| HCC1395 | TNBC | Basal B | Geldanamycin | HSP90 | HSP90 | 20 | uM | 9258.024 | 0.4623 | -0.5399 | 0.5251 | |
| HCC1395 | TNBC | Basal B | Geldanamycin | HSP90 | HSP90 | 100 | uM | 9258.024 | 0.4902 | -0.4856 | 0.5251 | |
| HCC1419 | HER2amp | Luminal | Geldanamycin | HSP90 | HSP90 | 0.000256 | uM | 7820.04 | 1.0089 | 1.0242 | 0.7382 | |
| HCC1419 | HER2amp | Luminal | Geldanamycin | HSP90 | HSP90 | 0.00128 | uM | 7820.04 | 1.0179 | 1.0486 | 0.7382 | |
| HCC1419 | HER2amp | Luminal | Geldanamycin | HSP90 | HSP90 | 0.0064 | uM | 7820.04 | 1.0285 | 1.0777 | 0.7382 | |
| HCC1419 | HER2amp | Luminal | Geldanamycin | HSP90 | HSP90 | 0.032 | uM | 7820.04 | 0.8024 | 0.4842 | 0.7382 | |
| HCC1419 | HER2amp | Luminal | Geldanamycin | HSP90 | HSP90 | 0.16 | uM | 7820.04 | 0.3829 | -0.4550 | 0.7382 | |
| HCC1419 | HER2amp | Luminal | Geldanamycin | HSP90 | HSP90 | 0.8 | uM | 7820.04 | 0.4270 | -0.3684 | 0.7382 | |
| HCC1419 | HER2amp | Luminal | Geldanamycin | HSP90 | HSP90 | 4 | uM | 7820.04 | 0.3476 | -0.5220 | 0.7382 | |
| HCC1419 | HER2amp | Luminal | Geldanamycin | HSP90 | HSP90 | 20 | uM | 7820.04 | 0.3432 | -0.5301 | 0.7382 | |
| HCC1419 | HER2amp | Luminal | Geldanamycin | HSP90 | HSP90 | 100 | uM | 7820.04 | 0.3404 | -0.5355 | 0.7382 | |
| HCC1419 | HER2amp | Luminal | Geldanamycin | HSP90 | HSP90 | 0.000256 | uM | 9278.012 | 1.0658 | 1.4165 | 0.3370 | |
| HCC1419 | HER2amp | Luminal | Geldanamycin | HSP90 | HSP90 | 0.00128 | uM | 9278.012 | 1.0622 | 1.3919 | 0.3370 | |
| HCC1419 | HER2amp | Luminal | Geldanamycin | HSP90 | HSP90 | 0.0064 | uM | 9278.012 | 1.0441 | 1.2733 | 0.3370 | |
| HCC1419 | HER2amp | Luminal | Geldanamycin | HSP90 | HSP90 | 0.032 | uM | 9278.012 | 0.4807 | -0.7725 | 0.3370 | |
| HCC1419 | HER2amp | Luminal | Geldanamycin | HSP90 | HSP90 | 0.16 | uM | 9278.012 | 0.2450 | -0.9692 | 0.3370 | |
| HCC1419 | HER2amp | Luminal | Geldanamycin | HSP90 | HSP90 | 0.8 | uM | 9278.012 | 0.2405 | -0.9709 | 0.3370 | |
| HCC1419 | HER2amp | Luminal | Geldanamycin | HSP90 | HSP90 | 4 | uM | 9278.012 | 0.2252 | -0.9760 | 0.3370 | |
| HCC1419 | HER2amp | Luminal | Geldanamycin | HSP90 | HSP90 | 20 | uM | 9278.012 | 0.1895 | -0.9856 | 0.3370 | |
| HCC1419 | HER2amp | Luminal | Geldanamycin | HSP90 | HSP90 | 100 | uM | 9278.012 | 0.1482 | -0.9931 | 0.3370 | |
| HCC1419 | HER2amp | Luminal | Geldanamycin | HSP90 | HSP90 | 0.000256 | uM | 10019.049 | 1.0481 | 1.2139 | 0.4626 | |
| HCC1419 | HER2amp | Luminal | Geldanamycin | HSP90 | HSP90 | 0.00128 | uM | 10019.049 | 1.1016 | 1.4652 | 0.4626 |