Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
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AU565 | HER2amp | Luminal | 5-DFUR | TYMS | TYMS | 5000 | uM | 10880.143 | 0.2530 | -0.1493 | 1.6077 | |
BT-20 | TNBC | Basal A | 5-DFUR | TYMS | TYMS | 0.0128 | uM | 10581.143 | 0.8773 | 0.7309 | 0.9062 | |
BT-20 | TNBC | Basal A | 5-DFUR | TYMS | TYMS | 0.064 | uM | 10581.143 | 0.8607 | 0.6948 | 0.9062 | |
BT-20 | TNBC | Basal A | 5-DFUR | TYMS | TYMS | 0.32 | uM | 10581.143 | 0.9419 | 0.8722 | 0.9062 | |
BT-20 | TNBC | Basal A | 5-DFUR | TYMS | TYMS | 1.6 | uM | 10581.143 | 0.9518 | 0.8940 | 0.9062 | |
BT-20 | TNBC | Basal A | 5-DFUR | TYMS | TYMS | 8 | uM | 10581.143 | 1.0124 | 1.0273 | 0.9062 | |
BT-20 | TNBC | Basal A | 5-DFUR | TYMS | TYMS | 40 | uM | 10581.143 | 0.8364 | 0.6422 | 0.9062 | |
BT-20 | TNBC | Basal A | 5-DFUR | TYMS | TYMS | 200 | uM | 10581.143 | 0.8042 | 0.5724 | 0.9062 | |
BT-20 | TNBC | Basal A | 5-DFUR | TYMS | TYMS | 1000 | uM | 10581.143 | 0.5903 | 0.1180 | 0.9062 | |
BT-20 | TNBC | Basal A | 5-DFUR | TYMS | TYMS | 5000 | uM | 10581.143 | 0.4492 | -0.1731 | 0.9062 | |
BT-20 | TNBC | Basal A | 5-DFUR | TYMS | TYMS | 0.0128 | uM | 11854.143 | 0.9547 | 0.9187 | 1.1185 | |
BT-20 | TNBC | Basal A | 5-DFUR | TYMS | TYMS | 0.064 | uM | 11854.143 | 1.0002 | 1.0003 | 1.1185 | |
BT-20 | TNBC | Basal A | 5-DFUR | TYMS | TYMS | 0.32 | uM | 11854.143 | 0.9898 | 0.9817 | 1.1185 | |
BT-20 | TNBC | Basal A | 5-DFUR | TYMS | TYMS | 1.6 | uM | 11854.143 | 0.9707 | 0.9475 | 1.1185 | |
BT-20 | TNBC | Basal A | 5-DFUR | TYMS | TYMS | 8 | uM | 11854.143 | 0.9550 | 0.9193 | 1.1185 | |
BT-20 | TNBC | Basal A | 5-DFUR | TYMS | TYMS | 40 | uM | 11854.143 | 0.8955 | 0.8120 | 1.1185 | |
BT-20 | TNBC | Basal A | 5-DFUR | TYMS | TYMS | 200 | uM | 11854.143 | 0.8024 | 0.6427 | 1.1185 | |
BT-20 | TNBC | Basal A | 5-DFUR | TYMS | TYMS | 1000 | uM | 11854.143 | 0.6272 | 0.3180 | 1.1185 | |
BT-20 | TNBC | Basal A | 5-DFUR | TYMS | TYMS | 5000 | uM | 11854.143 | 0.5289 | 0.1316 | 1.1185 | |
BT-474 | HER2amp | Luminal | 5-DFUR | TYMS | TYMS | 0.0128 | uM | 12056.143 | 0.9503 | 0.9013 | 1.0075 | |
BT-474 | HER2amp | Luminal | 5-DFUR | TYMS | TYMS | 0.064 | uM | 12056.143 | 0.9167 | 0.8346 | 1.0075 | |
BT-474 | HER2amp | Luminal | 5-DFUR | TYMS | TYMS | 0.32 | uM | 12056.143 | 0.9479 | 0.8965 | 1.0075 | |
BT-474 | HER2amp | Luminal | 5-DFUR | TYMS | TYMS | 1.6 | uM | 12056.143 | 0.9510 | 0.9027 | 1.0075 | |
BT-474 | HER2amp | Luminal | 5-DFUR | TYMS | TYMS | 8 | uM | 12056.143 | 0.9712 | 0.9427 | 1.0075 | |
BT-474 | HER2amp | Luminal | 5-DFUR | TYMS | TYMS | 40 | uM | 12056.143 | 0.8544 | 0.7108 | 1.0075 |