Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SUM225CWN | HER2amp | Basal A | Fascaplysin | CDK4 | CDK | 6.67 | uM | 7533.084 | 0.0094 | -0.9775 | 1.0396 | |
| SUM225CWN | HER2amp | Basal A | Fascaplysin | CDK4 | CDK | 33.3 | uM | 7533.084 | 0.0034 | -0.9915 | 1.0396 | |
| SUM225CWN | HER2amp | Basal A | Fascaplysin | CDK4 | CDK | 0.0000853 | uM | 7534.084 | 1.0180 | 1.0405 | 0.8905 | |
| SUM225CWN | HER2amp | Basal A | Fascaplysin | CDK4 | CDK | 0.000427 | uM | 7534.084 | 0.9931 | 0.9846 | 0.8905 | |
| SUM225CWN | HER2amp | Basal A | Fascaplysin | CDK4 | CDK | 0.00213 | uM | 7534.084 | 0.9941 | 0.9868 | 0.8905 | |
| SUM225CWN | HER2amp | Basal A | Fascaplysin | CDK4 | CDK | 0.0107 | uM | 7534.084 | 0.9552 | 0.8998 | 0.8905 | |
| SUM225CWN | HER2amp | Basal A | Fascaplysin | CDK4 | CDK | 0.0533 | uM | 7534.084 | 0.6074 | 0.1425 | 0.8905 | |
| SUM225CWN | HER2amp | Basal A | Fascaplysin | CDK4 | CDK | 0.267 | uM | 7534.084 | 0.3049 | -0.4730 | 0.8905 | |
| SUM225CWN | HER2amp | Basal A | Fascaplysin | CDK4 | CDK | 1.33 | uM | 7534.084 | 0.0090 | -0.9899 | 0.8905 | |
| SUM225CWN | HER2amp | Basal A | Fascaplysin | CDK4 | CDK | 6.67 | uM | 7534.084 | 0.0013 | -0.9989 | 0.8905 | |
| SUM225CWN | HER2amp | Basal A | Fascaplysin | CDK4 | CDK | 33.3 | uM | 7534.084 | 0.0004 | -0.9997 | 0.8905 | |
| SUM229PE | TNBC | - | Fascaplysin | CDK4 | CDK | 0.0000853 | uM | 7537.084 | 1.0022 | 1.0023 | 1.8684 | |
| SUM229PE | TNBC | - | Fascaplysin | CDK4 | CDK | 0.000427 | uM | 7537.084 | 0.9532 | 0.9494 | 1.8684 | |
| SUM229PE | TNBC | - | Fascaplysin | CDK4 | CDK | 0.00213 | uM | 7537.084 | 1.0202 | 1.0215 | 1.8684 | |
| SUM229PE | TNBC | - | Fascaplysin | CDK4 | CDK | 0.0107 | uM | 7537.084 | 0.9931 | 0.9926 | 1.8684 | |
| SUM229PE | TNBC | - | Fascaplysin | CDK4 | CDK | 0.0533 | uM | 7537.084 | 1.0515 | 1.0545 | 1.8684 | |
| SUM229PE | TNBC | - | Fascaplysin | CDK4 | CDK | 0.267 | uM | 7537.084 | 0.8369 | 0.8182 | 1.8684 | |
| SUM229PE | TNBC | - | Fascaplysin | CDK4 | CDK | 1.33 | uM | 7537.084 | 0.0237 | -0.7299 | 1.8684 | |
| SUM229PE | TNBC | - | Fascaplysin | CDK4 | CDK | 6.67 | uM | 7537.084 | 0.0067 | -0.8631 | 1.8684 | |
| SUM229PE | TNBC | - | Fascaplysin | CDK4 | CDK | 33.3 | uM | 7537.084 | 0.0061 | -0.8695 | 1.8684 | |
| SUM52PE | HR+ | Luminal | Fascaplysin | CDK4 | CDK | 0.0000853 | uM | 7541.084 | 0.9995 | 0.9992 | 1.2092 | |
| SUM52PE | HR+ | Luminal | Fascaplysin | CDK4 | CDK | 0.000427 | uM | 7541.084 | 1.0172 | 1.0284 | 1.2092 | |
| SUM52PE | HR+ | Luminal | Fascaplysin | CDK4 | CDK | 0.00213 | uM | 7541.084 | 0.9784 | 0.9641 | 1.2092 | |
| SUM52PE | HR+ | Luminal | Fascaplysin | CDK4 | CDK | 0.0107 | uM | 7541.084 | 0.9397 | 0.8998 | 1.2092 | |
| SUM52PE | HR+ | Luminal | Fascaplysin | CDK4 | CDK | 0.0533 | uM | 7541.084 | 0.8489 | 0.7466 | 1.2092 |