Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| MDA-MB-436 | TNBC | Basal B | Gefitinib | EGFR | ErbB | 0.267 | uM | 10266.024 | 0.9410 | 0.8221 | 0.6533 | |
| MDA-MB-436 | TNBC | Basal B | Gefitinib | EGFR | ErbB | 1.33 | uM | 10266.024 | 1.0077 | 1.0236 | 0.6533 | |
| MDA-MB-436 | TNBC | Basal B | Gefitinib | EGFR | ErbB | 6.67 | uM | 10266.024 | 0.9586 | 0.8746 | 0.6533 | |
| MDA-MB-436 | TNBC | Basal B | Gefitinib | EGFR | ErbB | 33.3 | uM | 10266.024 | 0.6969 | 0.1508 | 0.6533 | |
| MDA-MB-453 | TNBC | Luminal | Gefitinib | EGFR | ErbB | 0.0000853 | uM | 7903.016 | 1.0773 | 1.1376 | 1.1196 | |
| MDA-MB-453 | TNBC | Luminal | Gefitinib | EGFR | ErbB | 0.000427 | uM | 7903.016 | 1.0120 | 1.0214 | 1.1196 | |
| MDA-MB-453 | TNBC | Luminal | Gefitinib | EGFR | ErbB | 0.00213 | uM | 7903.016 | 0.9754 | 0.9560 | 1.1196 | |
| MDA-MB-453 | TNBC | Luminal | Gefitinib | EGFR | ErbB | 0.0107 | uM | 7903.016 | 1.1108 | 1.1968 | 1.1196 | |
| MDA-MB-453 | TNBC | Luminal | Gefitinib | EGFR | ErbB | 0.0533 | uM | 7903.016 | 0.9790 | 0.9625 | 1.1196 | |
| MDA-MB-453 | TNBC | Luminal | Gefitinib | EGFR | ErbB | 0.267 | uM | 7903.016 | 1.0516 | 1.0919 | 1.1196 | |
| MDA-MB-453 | TNBC | Luminal | Gefitinib | EGFR | ErbB | 1.33 | uM | 7903.016 | 1.0029 | 1.0052 | 1.1196 | |
| MDA-MB-453 | TNBC | Luminal | Gefitinib | EGFR | ErbB | 6.67 | uM | 7903.016 | 0.7087 | 0.4706 | 1.1196 | |
| MDA-MB-453 | TNBC | Luminal | Gefitinib | EGFR | ErbB | 33.3 | uM | 7903.016 | 0.0698 | -0.8145 | 1.1196 | |
| MDA-MB-453 | TNBC | Luminal | Gefitinib | EGFR | ErbB | 0.0000853 | uM | 9708.019 | 1.0336 | 1.0580 | 1.1580 | |
| MDA-MB-453 | TNBC | Luminal | Gefitinib | EGFR | ErbB | 0.000427 | uM | 9708.019 | 1.1126 | 1.1930 | 1.1580 | |
| MDA-MB-453 | TNBC | Luminal | Gefitinib | EGFR | ErbB | 0.00213 | uM | 9708.019 | 0.9979 | 0.9963 | 1.1580 | |
| MDA-MB-453 | TNBC | Luminal | Gefitinib | EGFR | ErbB | 0.0107 | uM | 9708.019 | 1.0685 | 1.1178 | 1.1580 | |
| MDA-MB-453 | TNBC | Luminal | Gefitinib | EGFR | ErbB | 0.0533 | uM | 9708.019 | 0.9906 | 0.9837 | 1.1580 | |
| MDA-MB-453 | TNBC | Luminal | Gefitinib | EGFR | ErbB | 0.267 | uM | 9708.019 | 1.0349 | 1.0601 | 1.1580 | |
| MDA-MB-453 | TNBC | Luminal | Gefitinib | EGFR | ErbB | 1.33 | uM | 9708.019 | 1.0131 | 1.0226 | 1.1580 | |
| MDA-MB-453 | TNBC | Luminal | Gefitinib | EGFR | ErbB | 6.67 | uM | 9708.019 | 0.7749 | 0.6047 | 1.1580 | |
| MDA-MB-453 | TNBC | Luminal | Gefitinib | EGFR | ErbB | 33.3 | uM | 9708.019 | 0.3001 | -0.2928 | 1.1580 | |
| MDA-MB-453 | TNBC | Luminal | Gefitinib | EGFR | ErbB | 0.0000853 | uM | 9723.049 | 1.1457 | 1.3069 | 0.9525 | |
| MDA-MB-453 | TNBC | Luminal | Gefitinib | EGFR | ErbB | 0.000427 | uM | 9723.049 | 1.0750 | 1.1578 | 0.9525 | |
| MDA-MB-453 | TNBC | Luminal | Gefitinib | EGFR | ErbB | 0.00213 | uM | 9723.049 | 1.1876 | 1.3957 | 0.9525 |