Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| HCC1419 | HER2amp | Luminal | Epirubicin | TOP2 | TOP | 6.9 | uM | 7821.017 | 0.2736 | -0.9345 | 0.3792 | |
| HCC1419 | HER2amp | Luminal | Epirubicin | TOP2 | TOP | 34.5 | uM | 7821.017 | 0.1810 | -0.9780 | 0.3792 | |
| HCC1419 | HER2amp | Luminal | Epirubicin | TOP2 | TOP | 172 | uM | 7821.017 | 0.0036 | -1.0000 | 0.3792 | |
| HCC1419 | HER2amp | Luminal | Epirubicin | TOP2 | TOP | 0.000441 | uM | 9278.017 | 1.0107 | 1.0394 | 0.5453 | |
| HCC1419 | HER2amp | Luminal | Epirubicin | TOP2 | TOP | 0.00221 | uM | 9278.017 | 1.0225 | 1.0831 | 0.5453 | |
| HCC1419 | HER2amp | Luminal | Epirubicin | TOP2 | TOP | 0.011 | uM | 9278.017 | 1.0047 | 1.0174 | 0.5453 | |
| HCC1419 | HER2amp | Luminal | Epirubicin | TOP2 | TOP | 0.0552 | uM | 9278.017 | 0.9810 | 0.9309 | 0.5453 | |
| HCC1419 | HER2amp | Luminal | Epirubicin | TOP2 | TOP | 0.276 | uM | 9278.017 | 0.9940 | 0.9780 | 0.5453 | |
| HCC1419 | HER2amp | Luminal | Epirubicin | TOP2 | TOP | 1.38 | uM | 9278.017 | 0.3518 | -0.7056 | 0.5453 | |
| HCC1419 | HER2amp | Luminal | Epirubicin | TOP2 | TOP | 6.9 | uM | 9278.017 | 0.3406 | -0.7225 | 0.5453 | |
| HCC1419 | HER2amp | Luminal | Epirubicin | TOP2 | TOP | 34.5 | uM | 9278.017 | 0.2541 | -0.8379 | 0.5453 | |
| HCC1419 | HER2amp | Luminal | Epirubicin | TOP2 | TOP | 172 | uM | 9278.017 | 0.0032 | -1.0000 | 0.5453 | |
| HCC1428 | HR+ | Luminal | Epirubicin | TOP2 | TOP | 0.000441 | uM | 9294.017 | 1.0328 | 1.0806 | 0.8160 | |
| HCC1428 | HR+ | Luminal | Epirubicin | TOP2 | TOP | 0.00221 | uM | 9294.017 | 1.0389 | 1.0958 | 0.8160 | |
| HCC1428 | HR+ | Luminal | Epirubicin | TOP2 | TOP | 0.011 | uM | 9294.017 | 1.0214 | 1.0526 | 0.8160 | |
| HCC1428 | HR+ | Luminal | Epirubicin | TOP2 | TOP | 0.0552 | uM | 9294.017 | 0.9825 | 0.9571 | 0.8160 | |
| HCC1428 | HR+ | Luminal | Epirubicin | TOP2 | TOP | 0.276 | uM | 9294.017 | 1.1117 | 1.2770 | 0.8160 | |
| HCC1428 | HR+ | Luminal | Epirubicin | TOP2 | TOP | 1.38 | uM | 9294.017 | 0.7361 | 0.3739 | 0.8160 | |
| HCC1428 | HR+ | Luminal | Epirubicin | TOP2 | TOP | 6.9 | uM | 9294.017 | 0.0601 | -0.9362 | 0.8160 | |
| HCC1428 | HR+ | Luminal | Epirubicin | TOP2 | TOP | 34.5 | uM | 9294.017 | 0.0494 | -0.9498 | 0.8160 | |
| HCC1428 | HR+ | Luminal | Epirubicin | TOP2 | TOP | 172 | uM | 9294.017 | 0.0013 | -0.9994 | 0.8160 | |
| HCC1569 | HER2amp | Basal A | Epirubicin | TOP2 | TOP | 0.000441 | uM | 7824.017 | 0.9824 | 0.9789 | 1.6694 | |
| HCC1569 | HER2amp | Basal A | Epirubicin | TOP2 | TOP | 0.00221 | uM | 7824.017 | 0.9758 | 0.9708 | 1.6694 | |
| HCC1569 | HER2amp | Basal A | Epirubicin | TOP2 | TOP | 0.011 | uM | 7824.017 | 1.0225 | 1.0269 | 1.6694 | |
| HCC1569 | HER2amp | Basal A | Epirubicin | TOP2 | TOP | 0.0552 | uM | 7824.017 | 0.8925 | 0.8683 | 1.6694 |