Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Hs 578T | TNBC | Basal B | Doxorubicin | TOP2 | TOP | 0.0276 | uM | 9511.034 | 0.8153 | 0.6660 | 1.1177 | |
| Hs 578T | TNBC | Basal B | Doxorubicin | TOP2 | TOP | 0.138 | uM | 9511.034 | 0.7229 | 0.4961 | 1.1177 | |
| Hs 578T | TNBC | Basal B | Doxorubicin | TOP2 | TOP | 0.69 | uM | 9511.034 | 0.3392 | -0.2398 | 1.1177 | |
| Hs 578T | TNBC | Basal B | Doxorubicin | TOP2 | TOP | 3.45 | uM | 9511.034 | 0.1992 | -0.5279 | 1.1177 | |
| Hs 578T | TNBC | Basal B | Doxorubicin | TOP2 | TOP | 17.2 | uM | 9511.034 | 0.1361 | -0.6643 | 1.1177 | |
| Hs 578T | TNBC | Basal B | Doxorubicin | TOP2 | TOP | 86.2 | uM | 9511.034 | 0.0083 | -0.9726 | 1.1177 | |
| LY2 | HR+ | Luminal | Doxorubicin | TOP2 | TOP | 0.000236 | uM | 10264.121 | 1.0476 | 1.0694 | 1.3643 | |
| LY2 | HR+ | Luminal | Doxorubicin | TOP2 | TOP | 0.00118 | uM | 10264.121 | 0.9345 | 0.9031 | 1.3643 | |
| LY2 | HR+ | Luminal | Doxorubicin | TOP2 | TOP | 0.00589 | uM | 10264.121 | 1.0261 | 1.0381 | 1.3643 | |
| LY2 | HR+ | Luminal | Doxorubicin | TOP2 | TOP | 0.0294 | uM | 10264.121 | 0.8665 | 0.8006 | 1.3643 | |
| LY2 | HR+ | Luminal | Doxorubicin | TOP2 | TOP | 0.147 | uM | 10264.121 | 0.8000 | 0.6983 | 1.3643 | |
| LY2 | HR+ | Luminal | Doxorubicin | TOP2 | TOP | 0.736 | uM | 10264.121 | 0.2546 | -0.2664 | 1.3643 | |
| LY2 | HR+ | Luminal | Doxorubicin | TOP2 | TOP | 3.68 | uM | 10264.121 | 0.3453 | -0.0827 | 1.3643 | |
| LY2 | HR+ | Luminal | Doxorubicin | TOP2 | TOP | 18.4 | uM | 10264.121 | 0.4025 | 0.0264 | 1.3643 | |
| LY2 | HR+ | Luminal | Doxorubicin | TOP2 | TOP | 92 | uM | 10264.121 | 0.0273 | -0.8571 | 1.3643 | |
| MB 157 | Unknown | Unknown | Doxorubicin | TOP2 | TOP | 0.000236 | uM | 9039.078 | 1.0011 | 1.0035 | 0.6306 | |
| MB 157 | Unknown | Unknown | Doxorubicin | TOP2 | TOP | 0.00118 | uM | 9039.078 | 0.9852 | 0.9532 | 0.6306 | |
| MB 157 | Unknown | Unknown | Doxorubicin | TOP2 | TOP | 0.00589 | uM | 9039.078 | 0.9639 | 0.8869 | 0.6306 | |
| MB 157 | Unknown | Unknown | Doxorubicin | TOP2 | TOP | 0.0294 | uM | 9039.078 | 0.9059 | 0.7100 | 0.6306 | |
| MB 157 | Unknown | Unknown | Doxorubicin | TOP2 | TOP | 0.147 | uM | 9039.078 | 0.7038 | 0.1458 | 0.6306 | |
| MB 157 | Unknown | Unknown | Doxorubicin | TOP2 | TOP | 0.736 | uM | 9039.078 | 0.0416 | -0.9871 | 0.6306 | |
| MB 157 | Unknown | Unknown | Doxorubicin | TOP2 | TOP | 3.68 | uM | 9039.078 | 0.0044 | -0.9996 | 0.6306 | |
| MB 157 | Unknown | Unknown | Doxorubicin | TOP2 | TOP | 18.4 | uM | 9039.078 | 0.0037 | -0.9997 | 0.6306 | |
| MB 157 | Unknown | Unknown | Doxorubicin | TOP2 | TOP | 92 | uM | 9039.078 | 0.0002 | -1.0000 | 0.6306 | |
| MCF 10A | NM | Basal B | Doxorubicin | TOP2 | TOP | 0.000221 | uM | 7870.007 | 1.0489 | 1.0467 | 2.0710 |