Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset - HMS LINCS Database

Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)

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Cell	Clinical Subtype	Transcriptional Subtype	Small Molecule	Perturbagen Target	Perturbagen Class	Perturbagen Concentration	Perturbagen Conc Unit	Biological Replicate ID	Relative Cell Count	Normalized Growth Rate Inhibition Value	Nominal Division Rate
MDA-MB-157	TNBC	Basal B	Cisplatin	DNA cross-linker	DNA cross-linker	10	uM	10093.021	0.7802	0.5258	0.9172
MDA-MB-157	TNBC	Basal B	Cisplatin	DNA cross-linker	DNA cross-linker	50	uM	10093.021	0.4504	-0.1619	0.9172
MDA-MB-157	TNBC	Basal B	Cisplatin	DNA cross-linker	DNA cross-linker	250	uM	10093.021	0.0121	-0.9838	0.9172
MDA-MB-175-VII	HR+	Luminal	Cisplatin	DNA cross-linker	DNA cross-linker	0.00064	uM	7885.017	1.0055	1.0197	0.5647
MDA-MB-175-VII	HR+	Luminal	Cisplatin	DNA cross-linker	DNA cross-linker	0.0032	uM	7885.017	0.9813	0.9341	0.5647
MDA-MB-175-VII	HR+	Luminal	Cisplatin	DNA cross-linker	DNA cross-linker	0.016	uM	7885.017	0.9979	0.9924	0.5647
MDA-MB-175-VII	HR+	Luminal	Cisplatin	DNA cross-linker	DNA cross-linker	0.08	uM	7885.017	0.8993	0.6572	0.5647
MDA-MB-175-VII	HR+	Luminal	Cisplatin	DNA cross-linker	DNA cross-linker	0.4	uM	7885.017	0.9866	0.9526	0.5647
MDA-MB-175-VII	HR+	Luminal	Cisplatin	DNA cross-linker	DNA cross-linker	2	uM	7885.017	0.9173	0.7165	0.5647
MDA-MB-175-VII	HR+	Luminal	Cisplatin	DNA cross-linker	DNA cross-linker	10	uM	7885.017	0.7183	0.1131	0.5647
MDA-MB-175-VII	HR+	Luminal	Cisplatin	DNA cross-linker	DNA cross-linker	50	uM	7885.017	0.2376	-0.8430	0.5647
MDA-MB-175-VII	HR+	Luminal	Cisplatin	DNA cross-linker	DNA cross-linker	250	uM	7885.017	0.0624	-0.9853	0.5647
MDA-MB-175-VII	HR+	Luminal	Cisplatin	DNA cross-linker	DNA cross-linker	0.00064	uM	7886.017	0.9721	0.9232	0.7230
MDA-MB-175-VII	HR+	Luminal	Cisplatin	DNA cross-linker	DNA cross-linker	0.0032	uM	7886.017	1.0121	1.0335	0.7230
MDA-MB-175-VII	HR+	Luminal	Cisplatin	DNA cross-linker	DNA cross-linker	0.016	uM	7886.017	1.0499	1.1393	0.7230
MDA-MB-175-VII	HR+	Luminal	Cisplatin	DNA cross-linker	DNA cross-linker	0.08	uM	7886.017	1.0081	1.0223	0.7230
MDA-MB-175-VII	HR+	Luminal	Cisplatin	DNA cross-linker	DNA cross-linker	0.4	uM	7886.017	0.9839	0.9556	0.7230
MDA-MB-175-VII	HR+	Luminal	Cisplatin	DNA cross-linker	DNA cross-linker	2	uM	7886.017	0.9024	0.7353	0.7230
MDA-MB-175-VII	HR+	Luminal	Cisplatin	DNA cross-linker	DNA cross-linker	10	uM	7886.017	0.5854	-0.0463	0.7230
MDA-MB-175-VII	HR+	Luminal	Cisplatin	DNA cross-linker	DNA cross-linker	50	uM	7886.017	0.2041	-0.7780	0.7230
MDA-MB-175-VII	HR+	Luminal	Cisplatin	DNA cross-linker	DNA cross-linker	250	uM	7886.017	0.0169	-0.9929	0.7230
MDA-MB-231	TNBC	Basal B	Cisplatin	DNA cross-linker	DNA cross-linker	0.00064	uM	7892.017	1.0255	1.0207	2.4495
MDA-MB-231	TNBC	Basal B	Cisplatin	DNA cross-linker	DNA cross-linker	0.0032	uM	7892.017	1.0591	1.0474	2.4495
MDA-MB-231	TNBC	Basal B	Cisplatin	DNA cross-linker	DNA cross-linker	0.016	uM	7892.017	1.0716	1.0572	2.4495
MDA-MB-231	TNBC	Basal B	Cisplatin	DNA cross-linker	DNA cross-linker	0.08	uM	7892.017	0.9653	0.9714	2.4495

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HMS LINCS Project

Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)