Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| MDA-MB-361 | HER2amp | Luminal | ZM-447439 | AURK | AURK | 0.0533 | uM | 10999.15 | 0.9420 | 0.8549 | 0.7928 | |
| MDA-MB-361 | HER2amp | Luminal | ZM-447439 | AURK | AURK | 0.267 | uM | 10999.15 | 0.9334 | 0.8333 | 0.7928 | |
| MDA-MB-361 | HER2amp | Luminal | ZM-447439 | AURK | AURK | 1.33 | uM | 10999.15 | 0.8039 | 0.5186 | 0.7928 | |
| MDA-MB-361 | HER2amp | Luminal | ZM-447439 | AURK | AURK | 6.67 | uM | 10999.15 | 0.7915 | 0.4892 | 0.7928 | |
| MDA-MB-361 | HER2amp | Luminal | ZM-447439 | AURK | AURK | 33.3 | uM | 10999.15 | 0.7871 | 0.4787 | 0.7928 | |
| MDA-MB-361 | HER2amp | Luminal | ZM-447439 | AURK | AURK | 0.000128 | uM | 12379.169 | 0.9783 | 0.9276 | 0.5957 | |
| MDA-MB-361 | HER2amp | Luminal | ZM-447439 | AURK | AURK | 0.00064 | uM | 12379.169 | 1.0259 | 1.0879 | 0.5957 | |
| MDA-MB-361 | HER2amp | Luminal | ZM-447439 | AURK | AURK | 0.0032 | uM | 12379.169 | 0.9872 | 0.9572 | 0.5957 | |
| MDA-MB-361 | HER2amp | Luminal | ZM-447439 | AURK | AURK | 0.016 | uM | 12379.169 | 0.9815 | 0.9382 | 0.5957 | |
| MDA-MB-361 | HER2amp | Luminal | ZM-447439 | AURK | AURK | 0.08 | uM | 12379.169 | 1.0354 | 1.1204 | 0.5957 | |
| MDA-MB-361 | HER2amp | Luminal | ZM-447439 | AURK | AURK | 0.4 | uM | 12379.169 | 1.0007 | 1.0023 | 0.5957 | |
| MDA-MB-361 | HER2amp | Luminal | ZM-447439 | AURK | AURK | 2 | uM | 12379.169 | 0.8754 | 0.5995 | 0.5957 | |
| MDA-MB-361 | HER2amp | Luminal | ZM-447439 | AURK | AURK | 10 | uM | 12379.169 | 0.8037 | 0.3859 | 0.5957 | |
| MDA-MB-361 | HER2amp | Luminal | ZM-447439 | AURK | AURK | 50 | uM | 12379.169 | 0.8626 | 0.5604 | 0.5957 | |
| MDA-MB-415 | HR+ | Luminal | ZM-447439 | AURK | AURK | 0.0000853 | uM | 10938.15 | 0.8395 | 0.6925 | 1.0480 | |
| MDA-MB-415 | HR+ | Luminal | ZM-447439 | AURK | AURK | 0.000427 | uM | 10938.15 | 0.8133 | 0.6420 | 1.0480 | |
| MDA-MB-415 | HR+ | Luminal | ZM-447439 | AURK | AURK | 0.00213 | uM | 10938.15 | 0.8234 | 0.6614 | 1.0480 | |
| MDA-MB-415 | HR+ | Luminal | ZM-447439 | AURK | AURK | 0.0107 | uM | 10938.15 | 0.8651 | 0.7418 | 1.0480 | |
| MDA-MB-415 | HR+ | Luminal | ZM-447439 | AURK | AURK | 0.0533 | uM | 10938.15 | 0.8950 | 0.7991 | 1.0480 | |
| MDA-MB-415 | HR+ | Luminal | ZM-447439 | AURK | AURK | 0.267 | uM | 10938.15 | 0.8301 | 0.6743 | 1.0480 | |
| MDA-MB-415 | HR+ | Luminal | ZM-447439 | AURK | AURK | 1.33 | uM | 10938.15 | 0.8958 | 0.8007 | 1.0480 | |
| MDA-MB-415 | HR+ | Luminal | ZM-447439 | AURK | AURK | 6.67 | uM | 10938.15 | 0.7594 | 0.5380 | 1.0480 | |
| MDA-MB-415 | HR+ | Luminal | ZM-447439 | AURK | AURK | 33.3 | uM | 10938.15 | 0.8206 | 0.6560 | 1.0480 | |
| MDA-MB-415 | HR+ | Luminal | ZM-447439 | AURK | AURK | 0.000128 | uM | 12333.169 | 0.9703 | 0.8938 | 0.5536 | |
| MDA-MB-415 | HR+ | Luminal | ZM-447439 | AURK | AURK | 0.00064 | uM | 12333.169 | 0.9437 | 0.8013 | 0.5536 |