Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| MDA-MB-415 | HR+ | Luminal | ZM-447439 | AURK | AURK | 0.0032 | uM | 12333.169 | 0.9679 | 0.8855 | 0.5536 | |
| MDA-MB-415 | HR+ | Luminal | ZM-447439 | AURK | AURK | 0.016 | uM | 12333.169 | 0.9097 | 0.6857 | 0.5536 | |
| MDA-MB-415 | HR+ | Luminal | ZM-447439 | AURK | AURK | 0.08 | uM | 12333.169 | 0.9746 | 0.9093 | 0.5536 | |
| MDA-MB-415 | HR+ | Luminal | ZM-447439 | AURK | AURK | 0.4 | uM | 12333.169 | 0.9873 | 0.9544 | 0.5536 | |
| MDA-MB-415 | HR+ | Luminal | ZM-447439 | AURK | AURK | 2 | uM | 12333.169 | 0.7881 | 0.3010 | 0.5536 | |
| MDA-MB-415 | HR+ | Luminal | ZM-447439 | AURK | AURK | 10 | uM | 12333.169 | 0.6835 | 0.0058 | 0.5536 | |
| MDA-MB-415 | HR+ | Luminal | ZM-447439 | AURK | AURK | 50 | uM | 12333.169 | 0.6867 | 0.0143 | 0.5536 | |
| MDA-MB-453 | TNBC | Luminal | ZM-447439 | AURK | AURK | 0.000128 | uM | 12414.169 | 0.9215 | 0.8595 | 1.1235 | |
| MDA-MB-453 | TNBC | Luminal | ZM-447439 | AURK | AURK | 0.00064 | uM | 12414.169 | 0.9470 | 0.9053 | 1.1235 | |
| MDA-MB-453 | TNBC | Luminal | ZM-447439 | AURK | AURK | 0.0032 | uM | 12414.169 | 0.9578 | 0.9246 | 1.1235 | |
| MDA-MB-453 | TNBC | Luminal | ZM-447439 | AURK | AURK | 0.016 | uM | 12414.169 | 0.9670 | 0.9411 | 1.1235 | |
| MDA-MB-453 | TNBC | Luminal | ZM-447439 | AURK | AURK | 0.08 | uM | 12414.169 | 1.0236 | 1.0419 | 1.1235 | |
| MDA-MB-453 | TNBC | Luminal | ZM-447439 | AURK | AURK | 0.4 | uM | 12414.169 | 0.9335 | 0.8811 | 1.1235 | |
| MDA-MB-453 | TNBC | Luminal | ZM-447439 | AURK | AURK | 2 | uM | 12414.169 | 0.7687 | 0.5825 | 1.1235 | |
| MDA-MB-453 | TNBC | Luminal | ZM-447439 | AURK | AURK | 10 | uM | 12414.169 | 0.7295 | 0.5105 | 1.1235 | |
| MDA-MB-453 | TNBC | Luminal | ZM-447439 | AURK | AURK | 50 | uM | 12414.169 | 0.7606 | 0.5676 | 1.1235 | |
| MX1 | Unknown | Unknown | ZM-447439 | AURK | AURK | 0.000256 | uM | 10644.138 | 0.9248 | 0.7405 | 0.5624 | |
| MX1 | Unknown | Unknown | ZM-447439 | AURK | AURK | 0.00128 | uM | 10644.138 | 0.9115 | 0.6962 | 0.5624 | |
| MX1 | Unknown | Unknown | ZM-447439 | AURK | AURK | 0.0064 | uM | 10644.138 | 0.9349 | 0.7743 | 0.5624 | |
| MX1 | Unknown | Unknown | ZM-447439 | AURK | AURK | 0.032 | uM | 10644.138 | 0.9935 | 0.9771 | 0.5624 | |
| MX1 | Unknown | Unknown | ZM-447439 | AURK | AURK | 0.16 | uM | 10644.138 | 0.9872 | 0.9548 | 0.5624 | |
| MX1 | Unknown | Unknown | ZM-447439 | AURK | AURK | 0.8 | uM | 10644.138 | 0.6574 | -0.0515 | 0.5624 | |
| MX1 | Unknown | Unknown | ZM-447439 | AURK | AURK | 4 | uM | 10644.138 | 0.3675 | -0.6628 | 0.5624 | |
| MX1 | Unknown | Unknown | ZM-447439 | AURK | AURK | 20 | uM | 10644.138 | 0.4013 | -0.6056 | 0.5624 | |
| MX1 | Unknown | Unknown | ZM-447439 | AURK | AURK | 100 | uM | 10644.138 | 0.0104 | -0.9994 | 0.5624 |