Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| MX1 | Unknown | Unknown | ZM-447439 | AURK | AURK | 0.0000853 | uM | 10874.15 | 0.9088 | 0.8012 | 0.9133 | |
| MX1 | Unknown | Unknown | ZM-447439 | AURK | AURK | 0.000427 | uM | 10874.15 | 0.9310 | 0.8493 | 0.9133 | |
| MX1 | Unknown | Unknown | ZM-447439 | AURK | AURK | 0.00213 | uM | 10874.15 | 0.9501 | 0.8909 | 0.9133 | |
| MX1 | Unknown | Unknown | ZM-447439 | AURK | AURK | 0.0107 | uM | 10874.15 | 0.8881 | 0.7562 | 0.9133 | |
| MX1 | Unknown | Unknown | ZM-447439 | AURK | AURK | 0.0533 | uM | 10874.15 | 0.9276 | 0.8421 | 0.9133 | |
| MX1 | Unknown | Unknown | ZM-447439 | AURK | AURK | 0.267 | uM | 10874.15 | 0.8524 | 0.6792 | 0.9133 | |
| MX1 | Unknown | Unknown | ZM-447439 | AURK | AURK | 1.33 | uM | 10874.15 | 0.6215 | 0.1882 | 0.9133 | |
| MX1 | Unknown | Unknown | ZM-447439 | AURK | AURK | 6.67 | uM | 10874.15 | 0.6519 | 0.2519 | 0.9133 | |
| MX1 | Unknown | Unknown | ZM-447439 | AURK | AURK | 33.3 | uM | 10874.15 | 0.6069 | 0.1577 | 0.9133 | |
| MX1 | Unknown | Unknown | ZM-447439 | AURK | AURK | 0.000256 | uM | 12220.16 | 1.0267 | 1.1230 | 0.4410 | |
| MX1 | Unknown | Unknown | ZM-447439 | AURK | AURK | 0.00128 | uM | 12220.16 | 1.0308 | 1.1423 | 0.4410 | |
| MX1 | Unknown | Unknown | ZM-447439 | AURK | AURK | 0.0064 | uM | 12220.16 | 1.0301 | 1.1390 | 0.4410 | |
| MX1 | Unknown | Unknown | ZM-447439 | AURK | AURK | 0.032 | uM | 12220.16 | 1.0885 | 1.4242 | 0.4410 | |
| MX1 | Unknown | Unknown | ZM-447439 | AURK | AURK | 0.16 | uM | 12220.16 | 1.1597 | 1.7983 | 0.4410 | |
| MX1 | Unknown | Unknown | ZM-447439 | AURK | AURK | 0.8 | uM | 12220.16 | 0.7972 | 0.1962 | 0.4410 | |
| MX1 | Unknown | Unknown | ZM-447439 | AURK | AURK | 4 | uM | 12220.16 | 0.5642 | -0.4538 | 0.4410 | |
| MX1 | Unknown | Unknown | ZM-447439 | AURK | AURK | 20 | uM | 12220.16 | 0.5075 | -0.5703 | 0.4410 | |
| MX1 | Unknown | Unknown | ZM-447439 | AURK | AURK | 100 | uM | 12220.16 | 0.3809 | -0.7759 | 0.4410 | |
| SK-BR-3 | HER2amp | Luminal | ZM-447439 | AURK | AURK | 0.000256 | uM | 11851.16 | 0.9484 | 0.9113 | 1.1668 | |
| SK-BR-3 | HER2amp | Luminal | ZM-447439 | AURK | AURK | 0.00128 | uM | 11851.16 | 0.9552 | 0.9230 | 1.1668 | |
| SK-BR-3 | HER2amp | Luminal | ZM-447439 | AURK | AURK | 0.0064 | uM | 11851.16 | 0.9815 | 0.9683 | 1.1668 | |
| SK-BR-3 | HER2amp | Luminal | ZM-447439 | AURK | AURK | 0.032 | uM | 11851.16 | 0.9616 | 0.9339 | 1.1668 | |
| SK-BR-3 | HER2amp | Luminal | ZM-447439 | AURK | AURK | 0.16 | uM | 11851.16 | 1.0106 | 1.0181 | 1.1668 | |
| SK-BR-3 | HER2amp | Luminal | ZM-447439 | AURK | AURK | 0.8 | uM | 11851.16 | 0.8806 | 0.7936 | 1.1668 | |
| SK-BR-3 | HER2amp | Luminal | ZM-447439 | AURK | AURK | 4 | uM | 11851.16 | 0.8483 | 0.7370 | 1.1668 |