Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| HCC1806 | TNBC | Basal A | ZM-447439 | AURK | AURK | 4 | uM | 12239.16 | 0.7972 | 0.7712 | 1.8654 | |
| HCC1806 | TNBC | Basal A | ZM-447439 | AURK | AURK | 20 | uM | 12239.16 | 0.8686 | 0.8545 | 1.8654 | |
| HCC1806 | TNBC | Basal A | ZM-447439 | AURK | AURK | 100 | uM | 12239.16 | 0.9312 | 0.9250 | 1.8654 | |
| HCC1937 | TNBC | Basal A | ZM-447439 | AURK | AURK | 0.000256 | uM | 11849.16 | 0.9565 | 0.9280 | 1.2119 | |
| HCC1937 | TNBC | Basal A | ZM-447439 | AURK | AURK | 0.00128 | uM | 11849.16 | 0.9981 | 0.9969 | 1.2119 | |
| HCC1937 | TNBC | Basal A | ZM-447439 | AURK | AURK | 0.0064 | uM | 11849.16 | 0.9503 | 0.9176 | 1.2119 | |
| HCC1937 | TNBC | Basal A | ZM-447439 | AURK | AURK | 0.032 | uM | 11849.16 | 0.9320 | 0.8870 | 1.2119 | |
| HCC1937 | TNBC | Basal A | ZM-447439 | AURK | AURK | 0.16 | uM | 11849.16 | 1.0320 | 1.0527 | 1.2119 | |
| HCC1937 | TNBC | Basal A | ZM-447439 | AURK | AURK | 0.8 | uM | 11849.16 | 0.8498 | 0.7487 | 1.2119 | |
| HCC1937 | TNBC | Basal A | ZM-447439 | AURK | AURK | 4 | uM | 11849.16 | 0.7831 | 0.6347 | 1.2119 | |
| HCC1937 | TNBC | Basal A | ZM-447439 | AURK | AURK | 20 | uM | 11849.16 | 0.5764 | 0.2693 | 1.2119 | |
| HCC1937 | TNBC | Basal A | ZM-447439 | AURK | AURK | 100 | uM | 11849.16 | 0.5618 | 0.2428 | 1.2119 | |
| HCC1954 | HER2amp | Basal A | ZM-447439 | AURK | AURK | 0.0000853 | uM | 11055.15 | 1.0185 | 1.0224 | 1.6412 | |
| HCC1954 | HER2amp | Basal A | ZM-447439 | AURK | AURK | 0.000427 | uM | 11055.15 | 1.0395 | 1.0478 | 1.6412 | |
| HCC1954 | HER2amp | Basal A | ZM-447439 | AURK | AURK | 0.00213 | uM | 11055.15 | 1.0529 | 1.0638 | 1.6412 | |
| HCC1954 | HER2amp | Basal A | ZM-447439 | AURK | AURK | 0.0107 | uM | 11055.15 | 1.0837 | 1.1004 | 1.6412 | |
| HCC1954 | HER2amp | Basal A | ZM-447439 | AURK | AURK | 0.0533 | uM | 11055.15 | 1.0456 | 1.0551 | 1.6412 | |
| HCC1954 | HER2amp | Basal A | ZM-447439 | AURK | AURK | 0.267 | uM | 11055.15 | 1.0259 | 1.0314 | 1.6412 | |
| HCC1954 | HER2amp | Basal A | ZM-447439 | AURK | AURK | 1.33 | uM | 11055.15 | 0.9952 | 0.9942 | 1.6412 | |
| HCC1954 | HER2amp | Basal A | ZM-447439 | AURK | AURK | 6.67 | uM | 11055.15 | 0.9190 | 0.8997 | 1.6412 | |
| HCC1954 | HER2amp | Basal A | ZM-447439 | AURK | AURK | 33.3 | uM | 11055.15 | 0.7644 | 0.6980 | 1.6412 | |
| HCC2185 | TNBC | Luminal | ZM-447439 | AURK | AURK | 0.0000853 | uM | 10996.15 | 1.0444 | 1.1779 | 0.5092 | |
| HCC2185 | TNBC | Luminal | ZM-447439 | AURK | AURK | 0.000427 | uM | 10996.15 | 1.0630 | 1.2549 | 0.5092 | |
| HCC2185 | TNBC | Luminal | ZM-447439 | AURK | AURK | 0.00213 | uM | 10996.15 | 1.0597 | 1.2411 | 0.5092 | |
| HCC2185 | TNBC | Luminal | ZM-447439 | AURK | AURK | 0.0107 | uM | 10996.15 | 1.0062 | 1.0245 | 0.5092 |