Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| HCC1428 | HR+ | Luminal | ZM-447439 | AURK | AURK | 100 | uM | 11936.16 | 0.8071 | 0.5747 | 0.8962 | |
| HCC1569 | HER2amp | Basal A | ZM-447439 | AURK | AURK | 0.0000853 | uM | 10872.15 | 0.9370 | 0.9215 | 1.6255 | |
| HCC1569 | HER2amp | Basal A | ZM-447439 | AURK | AURK | 0.000427 | uM | 10872.15 | 0.9581 | 0.9480 | 1.6255 | |
| HCC1569 | HER2amp | Basal A | ZM-447439 | AURK | AURK | 0.00213 | uM | 10872.15 | 0.9562 | 0.9456 | 1.6255 | |
| HCC1569 | HER2amp | Basal A | ZM-447439 | AURK | AURK | 0.0107 | uM | 10872.15 | 0.9048 | 0.8806 | 1.6255 | |
| HCC1569 | HER2amp | Basal A | ZM-447439 | AURK | AURK | 0.0533 | uM | 10872.15 | 0.9595 | 0.9498 | 1.6255 | |
| HCC1569 | HER2amp | Basal A | ZM-447439 | AURK | AURK | 0.267 | uM | 10872.15 | 0.8823 | 0.8517 | 1.6255 | |
| HCC1569 | HER2amp | Basal A | ZM-447439 | AURK | AURK | 1.33 | uM | 10872.15 | 0.6807 | 0.5786 | 1.6255 | |
| HCC1569 | HER2amp | Basal A | ZM-447439 | AURK | AURK | 6.67 | uM | 10872.15 | 0.6812 | 0.5793 | 1.6255 | |
| HCC1569 | HER2amp | Basal A | ZM-447439 | AURK | AURK | 33.3 | uM | 10872.15 | 0.6747 | 0.5700 | 1.6255 | |
| HCC1569 | HER2amp | Basal A | ZM-447439 | AURK | AURK | 0.000128 | uM | 12523.169 | 0.9603 | 0.9243 | 1.0498 | |
| HCC1569 | HER2amp | Basal A | ZM-447439 | AURK | AURK | 0.00064 | uM | 12523.169 | 0.9683 | 0.9396 | 1.0498 | |
| HCC1569 | HER2amp | Basal A | ZM-447439 | AURK | AURK | 0.0032 | uM | 12523.169 | 1.0172 | 1.0327 | 1.0498 | |
| HCC1569 | HER2amp | Basal A | ZM-447439 | AURK | AURK | 0.016 | uM | 12523.169 | 1.0216 | 1.0412 | 1.0498 | |
| HCC1569 | HER2amp | Basal A | ZM-447439 | AURK | AURK | 0.08 | uM | 12523.169 | 1.0018 | 1.0034 | 1.0498 | |
| HCC1569 | HER2amp | Basal A | ZM-447439 | AURK | AURK | 0.4 | uM | 12523.169 | 1.0622 | 1.1183 | 1.0498 | |
| HCC1569 | HER2amp | Basal A | ZM-447439 | AURK | AURK | 2 | uM | 12523.169 | 0.7625 | 0.5447 | 1.0498 | |
| HCC1569 | HER2amp | Basal A | ZM-447439 | AURK | AURK | 10 | uM | 12523.169 | 0.4924 | 0.0185 | 1.0498 | |
| HCC1569 | HER2amp | Basal A | ZM-447439 | AURK | AURK | 50 | uM | 12523.169 | 0.5481 | 0.1280 | 1.0498 | |
| HCC1806 | TNBC | Basal A | ZM-447439 | AURK | AURK | 0.000256 | uM | 12239.16 | 1.0184 | 1.0196 | 1.8654 | |
| HCC1806 | TNBC | Basal A | ZM-447439 | AURK | AURK | 0.00128 | uM | 12239.16 | 0.9861 | 0.9851 | 1.8654 | |
| HCC1806 | TNBC | Basal A | ZM-447439 | AURK | AURK | 0.0064 | uM | 12239.16 | 1.0234 | 1.0250 | 1.8654 | |
| HCC1806 | TNBC | Basal A | ZM-447439 | AURK | AURK | 0.032 | uM | 12239.16 | 1.0040 | 1.0043 | 1.8654 | |
| HCC1806 | TNBC | Basal A | ZM-447439 | AURK | AURK | 0.16 | uM | 12239.16 | 1.0604 | 1.0638 | 1.8654 | |
| HCC1806 | TNBC | Basal A | ZM-447439 | AURK | AURK | 0.8 | uM | 12239.16 | 0.9642 | 0.9612 | 1.8654 |