Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| MDA-MB-175-VII | HR+ | Luminal | ZM-447439 | AURK | AURK | 1.33 | uM | 10818.15 | 0.8764 | 0.4806 | 0.4390 | |
| MDA-MB-175-VII | HR+ | Luminal | ZM-447439 | AURK | AURK | 6.67 | uM | 10818.15 | 0.8601 | 0.4187 | 0.4390 | |
| MDA-MB-175-VII | HR+ | Luminal | ZM-447439 | AURK | AURK | 33.3 | uM | 10818.15 | 0.8207 | 0.2751 | 0.4390 | |
| MDA-MB-175-VII | HR+ | Luminal | ZM-447439 | AURK | AURK | 0.000256 | uM | 12126.16 | 0.9225 | 0.7802 | 0.6930 | |
| MDA-MB-175-VII | HR+ | Luminal | ZM-447439 | AURK | AURK | 0.00128 | uM | 12126.16 | 0.9070 | 0.7373 | 0.6930 | |
| MDA-MB-175-VII | HR+ | Luminal | ZM-447439 | AURK | AURK | 0.0064 | uM | 12126.16 | 0.9436 | 0.8392 | 0.6930 | |
| MDA-MB-175-VII | HR+ | Luminal | ZM-447439 | AURK | AURK | 0.032 | uM | 12126.16 | 0.9324 | 0.8080 | 0.6930 | |
| MDA-MB-175-VII | HR+ | Luminal | ZM-447439 | AURK | AURK | 0.16 | uM | 12126.16 | 0.9016 | 0.7222 | 0.6930 | |
| MDA-MB-175-VII | HR+ | Luminal | ZM-447439 | AURK | AURK | 0.8 | uM | 12126.16 | 0.8383 | 0.5505 | 0.6930 | |
| MDA-MB-175-VII | HR+ | Luminal | ZM-447439 | AURK | AURK | 4 | uM | 12126.16 | 0.8454 | 0.5696 | 0.6930 | |
| MDA-MB-175-VII | HR+ | Luminal | ZM-447439 | AURK | AURK | 20 | uM | 12126.16 | 0.8175 | 0.4954 | 0.6930 | |
| MDA-MB-175-VII | HR+ | Luminal | ZM-447439 | AURK | AURK | 100 | uM | 12126.16 | 0.8284 | 0.5242 | 0.6930 | |
| MDA-MB-361 | HER2amp | Luminal | ZM-447439 | AURK | AURK | 0.000256 | uM | 10643.138 | 0.9519 | 0.8116 | 0.4981 | |
| MDA-MB-361 | HER2amp | Luminal | ZM-447439 | AURK | AURK | 0.00128 | uM | 10643.138 | 0.9795 | 0.9185 | 0.4981 | |
| MDA-MB-361 | HER2amp | Luminal | ZM-447439 | AURK | AURK | 0.0064 | uM | 10643.138 | 0.9807 | 0.9233 | 0.4981 | |
| MDA-MB-361 | HER2amp | Luminal | ZM-447439 | AURK | AURK | 0.032 | uM | 10643.138 | 1.0380 | 1.1553 | 0.4981 | |
| MDA-MB-361 | HER2amp | Luminal | ZM-447439 | AURK | AURK | 0.16 | uM | 10643.138 | 1.0022 | 1.0089 | 0.4981 | |
| MDA-MB-361 | HER2amp | Luminal | ZM-447439 | AURK | AURK | 0.8 | uM | 10643.138 | 0.9241 | 0.7069 | 0.4981 | |
| MDA-MB-361 | HER2amp | Luminal | ZM-447439 | AURK | AURK | 4 | uM | 10643.138 | 0.8729 | 0.5223 | 0.4981 | |
| MDA-MB-361 | HER2amp | Luminal | ZM-447439 | AURK | AURK | 20 | uM | 10643.138 | 0.8538 | 0.4562 | 0.4981 | |
| MDA-MB-361 | HER2amp | Luminal | ZM-447439 | AURK | AURK | 100 | uM | 10643.138 | 0.0608 | -0.9928 | 0.4981 | |
| MDA-MB-361 | HER2amp | Luminal | ZM-447439 | AURK | AURK | 0.0000853 | uM | 10999.15 | 0.9759 | 0.9395 | 0.7928 | |
| MDA-MB-361 | HER2amp | Luminal | ZM-447439 | AURK | AURK | 0.000427 | uM | 10999.15 | 0.9477 | 0.8689 | 0.7928 | |
| MDA-MB-361 | HER2amp | Luminal | ZM-447439 | AURK | AURK | 0.00213 | uM | 10999.15 | 0.9855 | 0.9636 | 0.7928 | |
| MDA-MB-361 | HER2amp | Luminal | ZM-447439 | AURK | AURK | 0.0107 | uM | 10999.15 | 0.9851 | 0.9625 | 0.7928 |