Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| MDA-MB-134-VI | HR+ | Luminal | ZM-447439 | AURK | AURK | 100 | uM | 12206.16 | 0.6837 | 0.3607 | 0.9874 | |
| MDA-MB-157 | TNBC | Basal B | ZM-447439 | AURK | AURK | 0.000128 | uM | 12594.169 | 0.9939 | 0.9913 | 1.4097 | |
| MDA-MB-157 | TNBC | Basal B | ZM-447439 | AURK | AURK | 0.00064 | uM | 12594.169 | 1.0195 | 1.0276 | 1.4097 | |
| MDA-MB-157 | TNBC | Basal B | ZM-447439 | AURK | AURK | 0.0032 | uM | 12594.169 | 0.9834 | 0.9764 | 1.4097 | |
| MDA-MB-157 | TNBC | Basal B | ZM-447439 | AURK | AURK | 0.016 | uM | 12594.169 | 0.9683 | 0.9549 | 1.4097 | |
| MDA-MB-157 | TNBC | Basal B | ZM-447439 | AURK | AURK | 0.08 | uM | 12594.169 | 1.0480 | 1.0676 | 1.4097 | |
| MDA-MB-157 | TNBC | Basal B | ZM-447439 | AURK | AURK | 0.4 | uM | 12594.169 | 1.0414 | 1.0583 | 1.4097 | |
| MDA-MB-157 | TNBC | Basal B | ZM-447439 | AURK | AURK | 2 | uM | 12594.169 | 0.7196 | 0.5836 | 1.4097 | |
| MDA-MB-157 | TNBC | Basal B | ZM-447439 | AURK | AURK | 10 | uM | 12594.169 | 0.6202 | 0.4251 | 1.4097 | |
| MDA-MB-157 | TNBC | Basal B | ZM-447439 | AURK | AURK | 50 | uM | 12594.169 | 0.7334 | 0.6051 | 1.4097 | |
| MDA-MB-175-VII | HR+ | Luminal | ZM-447439 | AURK | AURK | 0.000256 | uM | 10642.138 | 0.8976 | 0.6503 | 0.5620 | |
| MDA-MB-175-VII | HR+ | Luminal | ZM-447439 | AURK | AURK | 0.00128 | uM | 10642.138 | 0.9379 | 0.7843 | 0.5620 | |
| MDA-MB-175-VII | HR+ | Luminal | ZM-447439 | AURK | AURK | 0.0064 | uM | 10642.138 | 0.9247 | 0.7398 | 0.5620 | |
| MDA-MB-175-VII | HR+ | Luminal | ZM-447439 | AURK | AURK | 0.032 | uM | 10642.138 | 0.9994 | 0.9978 | 0.5620 | |
| MDA-MB-175-VII | HR+ | Luminal | ZM-447439 | AURK | AURK | 0.16 | uM | 10642.138 | 0.9471 | 0.8156 | 0.5620 | |
| MDA-MB-175-VII | HR+ | Luminal | ZM-447439 | AURK | AURK | 0.8 | uM | 10642.138 | 0.8753 | 0.5778 | 0.5620 | |
| MDA-MB-175-VII | HR+ | Luminal | ZM-447439 | AURK | AURK | 4 | uM | 10642.138 | 0.8473 | 0.4894 | 0.5620 | |
| MDA-MB-175-VII | HR+ | Luminal | ZM-447439 | AURK | AURK | 20 | uM | 10642.138 | 0.8462 | 0.4859 | 0.5620 | |
| MDA-MB-175-VII | HR+ | Luminal | ZM-447439 | AURK | AURK | 100 | uM | 10642.138 | 0.0101 | -0.9994 | 0.5620 | |
| MDA-MB-175-VII | HR+ | Luminal | ZM-447439 | AURK | AURK | 0.0000853 | uM | 10818.15 | 0.9233 | 0.6675 | 0.4390 | |
| MDA-MB-175-VII | HR+ | Luminal | ZM-447439 | AURK | AURK | 0.000427 | uM | 10818.15 | 0.9320 | 0.7034 | 0.4390 | |
| MDA-MB-175-VII | HR+ | Luminal | ZM-447439 | AURK | AURK | 0.00213 | uM | 10818.15 | 0.9547 | 0.7997 | 0.4390 | |
| MDA-MB-175-VII | HR+ | Luminal | ZM-447439 | AURK | AURK | 0.0107 | uM | 10818.15 | 0.9713 | 0.8715 | 0.4390 | |
| MDA-MB-175-VII | HR+ | Luminal | ZM-447439 | AURK | AURK | 0.0533 | uM | 10818.15 | 0.9590 | 0.8179 | 0.4390 | |
| MDA-MB-175-VII | HR+ | Luminal | ZM-447439 | AURK | AURK | 0.267 | uM | 10818.15 | 0.9218 | 0.6614 | 0.4390 |