Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| MB 157 | Unknown | Unknown | ZM-447439 | AURK | AURK | 0.4 | uM | 12580.169 | 0.9770 | 0.9785 | 2.1524 | |
| MB 157 | Unknown | Unknown | ZM-447439 | AURK | AURK | 2 | uM | 12580.169 | 0.1160 | -0.2649 | 2.1524 | |
| MB 157 | Unknown | Unknown | ZM-447439 | AURK | AURK | 10 | uM | 12580.169 | 0.1625 | -0.1402 | 2.1524 | |
| MB 157 | Unknown | Unknown | ZM-447439 | AURK | AURK | 50 | uM | 12580.169 | 0.0936 | -0.3346 | 2.1524 | |
| MCF 10A | NM | Basal B | ZM-447439 | AURK | AURK | 0.0000853 | uM | 11056.15 | 0.9708 | 0.9805 | 3.0207 | |
| MCF 10A | NM | Basal B | ZM-447439 | AURK | AURK | 0.000427 | uM | 11056.15 | 1.0083 | 1.0055 | 3.0207 | |
| MCF 10A | NM | Basal B | ZM-447439 | AURK | AURK | 0.00213 | uM | 11056.15 | 1.0517 | 1.0336 | 3.0207 | |
| MCF 10A | NM | Basal B | ZM-447439 | AURK | AURK | 0.0107 | uM | 11056.15 | 0.9867 | 0.9912 | 3.0207 | |
| MCF 10A | NM | Basal B | ZM-447439 | AURK | AURK | 0.0533 | uM | 11056.15 | 0.9863 | 0.9909 | 3.0207 | |
| MCF 10A | NM | Basal B | ZM-447439 | AURK | AURK | 0.267 | uM | 11056.15 | 0.9103 | 0.9387 | 3.0207 | |
| MCF 10A | NM | Basal B | ZM-447439 | AURK | AURK | 1.33 | uM | 11056.15 | 0.6147 | 0.7024 | 3.0207 | |
| MCF 10A | NM | Basal B | ZM-447439 | AURK | AURK | 6.67 | uM | 11056.15 | 0.5972 | 0.6862 | 3.0207 | |
| MCF 10A | NM | Basal B | ZM-447439 | AURK | AURK | 33.3 | uM | 11056.15 | 0.5915 | 0.6809 | 3.0207 | |
| MCF 10F | NM | - | ZM-447439 | AURK | AURK | 0.000256 | uM | 12254.16 | 1.0703 | 1.0992 | 1.4029 | |
| MCF 10F | NM | - | ZM-447439 | AURK | AURK | 0.00128 | uM | 12254.16 | 1.0976 | 1.1373 | 1.4029 | |
| MCF 10F | NM | - | ZM-447439 | AURK | AURK | 0.0064 | uM | 12254.16 | 1.0618 | 1.0873 | 1.4029 | |
| MCF 10F | NM | - | ZM-447439 | AURK | AURK | 0.032 | uM | 12254.16 | 1.0666 | 1.0941 | 1.4029 | |
| MCF 10F | NM | - | ZM-447439 | AURK | AURK | 0.16 | uM | 12254.16 | 1.0750 | 1.1058 | 1.4029 | |
| MCF 10F | NM | - | ZM-447439 | AURK | AURK | 0.8 | uM | 12254.16 | 1.0365 | 1.0518 | 1.4029 | |
| MCF 10F | NM | - | ZM-447439 | AURK | AURK | 4 | uM | 12254.16 | 0.8125 | 0.7249 | 1.4029 | |
| MCF 10F | NM | - | ZM-447439 | AURK | AURK | 20 | uM | 12254.16 | 0.8948 | 0.8477 | 1.4029 | |
| MCF 10F | NM | - | ZM-447439 | AURK | AURK | 100 | uM | 12254.16 | 0.7142 | 0.5734 | 1.4029 | |
| MCF12A | NM | Basal B | ZM-447439 | AURK | AURK | 0.0000853 | uM | 10817.15 | 0.9899 | 0.9852 | 1.3689 | |
| MCF12A | NM | Basal B | ZM-447439 | AURK | AURK | 0.000427 | uM | 10817.15 | 0.9919 | 0.9882 | 1.3689 | |
| MCF12A | NM | Basal B | ZM-447439 | AURK | AURK | 0.00213 | uM | 10817.15 | 0.9647 | 0.9481 | 1.3689 |