Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| MCF12A | NM | Basal B | ZM-447439 | AURK | AURK | 0.0107 | uM | 10817.15 | 1.0175 | 1.0255 | 1.3689 | |
| MCF12A | NM | Basal B | ZM-447439 | AURK | AURK | 0.0533 | uM | 10817.15 | 1.0174 | 1.0254 | 1.3689 | |
| MCF12A | NM | Basal B | ZM-447439 | AURK | AURK | 0.267 | uM | 10817.15 | 0.9631 | 0.9458 | 1.3689 | |
| MCF12A | NM | Basal B | ZM-447439 | AURK | AURK | 1.33 | uM | 10817.15 | 0.6638 | 0.4827 | 1.3689 | |
| MCF12A | NM | Basal B | ZM-447439 | AURK | AURK | 6.67 | uM | 10817.15 | 0.6378 | 0.4400 | 1.3689 | |
| MCF12A | NM | Basal B | ZM-447439 | AURK | AURK | 33.3 | uM | 10817.15 | 0.6330 | 0.4320 | 1.3689 | |
| MCF12A | NM | Basal B | ZM-447439 | AURK | AURK | 0.000128 | uM | 12365.169 | 0.9582 | 0.9613 | 2.1831 | |
| MCF12A | NM | Basal B | ZM-447439 | AURK | AURK | 0.00064 | uM | 12365.169 | 1.0982 | 1.0877 | 2.1831 | |
| MCF12A | NM | Basal B | ZM-447439 | AURK | AURK | 0.0032 | uM | 12365.169 | 0.9945 | 0.9949 | 2.1831 | |
| MCF12A | NM | Basal B | ZM-447439 | AURK | AURK | 0.016 | uM | 12365.169 | 0.9673 | 0.9697 | 2.1831 | |
| MCF12A | NM | Basal B | ZM-447439 | AURK | AURK | 0.08 | uM | 12365.169 | 1.0338 | 1.0307 | 2.1831 | |
| MCF12A | NM | Basal B | ZM-447439 | AURK | AURK | 0.4 | uM | 12365.169 | 0.9353 | 0.9397 | 2.1831 | |
| MCF12A | NM | Basal B | ZM-447439 | AURK | AURK | 2 | uM | 12365.169 | 0.6539 | 0.6464 | 2.1831 | |
| MCF12A | NM | Basal B | ZM-447439 | AURK | AURK | 10 | uM | 12365.169 | 0.6194 | 0.6059 | 2.1831 | |
| MCF12A | NM | Basal B | ZM-447439 | AURK | AURK | 50 | uM | 12365.169 | 0.6731 | 0.6683 | 2.1831 | |
| MCF7 | HR+ | Luminal | ZM-447439 | AURK | AURK | 0.0000853 | uM | 10997.15 | 0.9211 | 0.8877 | 1.4218 | |
| MCF7 | HR+ | Luminal | ZM-447439 | AURK | AURK | 0.000427 | uM | 10997.15 | 0.8947 | 0.8495 | 1.4218 | |
| MCF7 | HR+ | Luminal | ZM-447439 | AURK | AURK | 0.00213 | uM | 10997.15 | 0.9172 | 0.8820 | 1.4218 | |
| MCF7 | HR+ | Luminal | ZM-447439 | AURK | AURK | 0.0107 | uM | 10997.15 | 1.0032 | 1.0045 | 1.4218 | |
| MCF7 | HR+ | Luminal | ZM-447439 | AURK | AURK | 0.0533 | uM | 10997.15 | 0.8646 | 0.8055 | 1.4218 | |
| MCF7 | HR+ | Luminal | ZM-447439 | AURK | AURK | 0.267 | uM | 10997.15 | 0.9163 | 0.8807 | 1.4218 | |
| MCF7 | HR+ | Luminal | ZM-447439 | AURK | AURK | 1.33 | uM | 10997.15 | 0.7965 | 0.7042 | 1.4218 | |
| MCF7 | HR+ | Luminal | ZM-447439 | AURK | AURK | 6.67 | uM | 10997.15 | 0.8325 | 0.7581 | 1.4218 | |
| MCF7 | HR+ | Luminal | ZM-447439 | AURK | AURK | 33.3 | uM | 10997.15 | 0.8069 | 0.7198 | 1.4218 | |
| MDA-MB-134-VI | HR+ | Luminal | ZM-447439 | AURK | AURK | 0.000256 | uM | 10519.138 | 0.9373 | 0.8814 | 1.0592 |