Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| BT-549 | TNBC | Basal B | ZM-447439 | AURK | AURK | 10 | uM | 12305.169 | 0.1751 | 0.0176 | 2.5786 | |
| BT-549 | TNBC | Basal B | ZM-447439 | AURK | AURK | 50 | uM | 12305.169 | 0.3035 | 0.2595 | 2.5786 | |
| CAMA-1 | HR+ | Luminal | ZM-447439 | AURK | AURK | 0.000256 | uM | 10473.138 | 0.9613 | 0.9396 | 1.2872 | |
| CAMA-1 | HR+ | Luminal | ZM-447439 | AURK | AURK | 0.00128 | uM | 10473.138 | 1.0040 | 1.0062 | 1.2872 | |
| CAMA-1 | HR+ | Luminal | ZM-447439 | AURK | AURK | 0.0064 | uM | 10473.138 | 0.9492 | 0.9206 | 1.2872 | |
| CAMA-1 | HR+ | Luminal | ZM-447439 | AURK | AURK | 0.032 | uM | 10473.138 | 1.0208 | 1.0323 | 1.2872 | |
| CAMA-1 | HR+ | Luminal | ZM-447439 | AURK | AURK | 0.16 | uM | 10473.138 | 0.9796 | 0.9683 | 1.2872 | |
| CAMA-1 | HR+ | Luminal | ZM-447439 | AURK | AURK | 0.8 | uM | 10473.138 | 0.9039 | 0.8491 | 1.2872 | |
| CAMA-1 | HR+ | Luminal | ZM-447439 | AURK | AURK | 4 | uM | 10473.138 | 0.8379 | 0.7432 | 1.2872 | |
| CAMA-1 | HR+ | Luminal | ZM-447439 | AURK | AURK | 20 | uM | 10473.138 | 0.8149 | 0.7059 | 1.2872 | |
| CAMA-1 | HR+ | Luminal | ZM-447439 | AURK | AURK | 100 | uM | 10473.138 | 0.9162 | 0.8685 | 1.2872 | |
| CAMA-1 | HR+ | Luminal | ZM-447439 | AURK | AURK | 0.0000853 | uM | 10755.15 | 0.8656 | 0.6623 | 0.7807 | |
| CAMA-1 | HR+ | Luminal | ZM-447439 | AURK | AURK | 0.000427 | uM | 10755.15 | 0.8565 | 0.6399 | 0.7807 | |
| CAMA-1 | HR+ | Luminal | ZM-447439 | AURK | AURK | 0.00213 | uM | 10755.15 | 0.8898 | 0.7222 | 0.7807 | |
| CAMA-1 | HR+ | Luminal | ZM-447439 | AURK | AURK | 0.0107 | uM | 10755.15 | 0.8929 | 0.7299 | 0.7807 | |
| CAMA-1 | HR+ | Luminal | ZM-447439 | AURK | AURK | 0.0533 | uM | 10755.15 | 0.8735 | 0.6818 | 0.7807 | |
| CAMA-1 | HR+ | Luminal | ZM-447439 | AURK | AURK | 0.267 | uM | 10755.15 | 0.9715 | 0.9272 | 0.7807 | |
| CAMA-1 | HR+ | Luminal | ZM-447439 | AURK | AURK | 1.33 | uM | 10755.15 | 0.8171 | 0.5439 | 0.7807 | |
| CAMA-1 | HR+ | Luminal | ZM-447439 | AURK | AURK | 6.67 | uM | 10755.15 | 0.8198 | 0.5506 | 0.7807 | |
| CAMA-1 | HR+ | Luminal | ZM-447439 | AURK | AURK | 33.3 | uM | 10755.15 | 0.7553 | 0.3961 | 0.7807 | |
| CAMA-1 | HR+ | Luminal | ZM-447439 | AURK | AURK | 0.000256 | uM | 12070.16 | 0.8998 | 0.7651 | 0.8453 | |
| CAMA-1 | HR+ | Luminal | ZM-447439 | AURK | AURK | 0.00128 | uM | 12070.16 | 1.0533 | 1.1268 | 0.8453 | |
| CAMA-1 | HR+ | Luminal | ZM-447439 | AURK | AURK | 0.0064 | uM | 12070.16 | 0.9112 | 0.7917 | 0.8453 | |
| CAMA-1 | HR+ | Luminal | ZM-447439 | AURK | AURK | 0.032 | uM | 12070.16 | 0.9707 | 0.9309 | 0.8453 | |
| CAMA-1 | HR+ | Luminal | ZM-447439 | AURK | AURK | 0.16 | uM | 12070.16 | 0.8911 | 0.7451 | 0.8453 |