Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
Download: Excel (XLSX), Comma-separated (CSV)
| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| BT-483 | HR+ | Luminal | ZM-447439 | AURK | AURK | 0.0000853 | uM | 10696.15 | 0.9411 | 0.7597 | 0.4740 | |
| BT-483 | HR+ | Luminal | ZM-447439 | AURK | AURK | 0.000427 | uM | 10696.15 | 0.9373 | 0.7447 | 0.4740 | |
| BT-483 | HR+ | Luminal | ZM-447439 | AURK | AURK | 0.00213 | uM | 10696.15 | 0.9619 | 0.8427 | 0.4740 | |
| BT-483 | HR+ | Luminal | ZM-447439 | AURK | AURK | 0.0107 | uM | 10696.15 | 0.9865 | 0.9436 | 0.4740 | |
| BT-483 | HR+ | Luminal | ZM-447439 | AURK | AURK | 0.0533 | uM | 10696.15 | 0.9912 | 0.9628 | 0.4740 | |
| BT-483 | HR+ | Luminal | ZM-447439 | AURK | AURK | 0.267 | uM | 10696.15 | 0.9973 | 0.9885 | 0.4740 | |
| BT-483 | HR+ | Luminal | ZM-447439 | AURK | AURK | 1.33 | uM | 10696.15 | 0.9859 | 0.9411 | 0.4740 | |
| BT-483 | HR+ | Luminal | ZM-447439 | AURK | AURK | 6.67 | uM | 10696.15 | 0.8788 | 0.5229 | 0.4740 | |
| BT-483 | HR+ | Luminal | ZM-447439 | AURK | AURK | 33.3 | uM | 10696.15 | 0.8566 | 0.4427 | 0.4740 | |
| BT-483 | HR+ | Luminal | ZM-447439 | AURK | AURK | 0.000256 | uM | 11855.16 | 0.9012 | 0.7034 | 0.6477 | |
| BT-483 | HR+ | Luminal | ZM-447439 | AURK | AURK | 0.00128 | uM | 11855.16 | 0.8505 | 0.5576 | 0.6477 | |
| BT-483 | HR+ | Luminal | ZM-447439 | AURK | AURK | 0.0064 | uM | 11855.16 | 0.9022 | 0.7062 | 0.6477 | |
| BT-483 | HR+ | Luminal | ZM-447439 | AURK | AURK | 0.032 | uM | 11855.16 | 0.9406 | 0.8196 | 0.6477 | |
| BT-483 | HR+ | Luminal | ZM-447439 | AURK | AURK | 0.16 | uM | 11855.16 | 0.9491 | 0.8451 | 0.6477 | |
| BT-483 | HR+ | Luminal | ZM-447439 | AURK | AURK | 0.8 | uM | 11855.16 | 0.8754 | 0.6284 | 0.6477 | |
| BT-483 | HR+ | Luminal | ZM-447439 | AURK | AURK | 4 | uM | 11855.16 | 0.9116 | 0.7338 | 0.6477 | |
| BT-483 | HR+ | Luminal | ZM-447439 | AURK | AURK | 20 | uM | 11855.16 | 0.8453 | 0.5429 | 0.6477 | |
| BT-483 | HR+ | Luminal | ZM-447439 | AURK | AURK | 100 | uM | 11855.16 | 0.8768 | 0.6325 | 0.6477 | |
| BT-549 | TNBC | Basal B | ZM-447439 | AURK | AURK | 0.000128 | uM | 12305.169 | 1.0808 | 1.0612 | 2.5786 | |
| BT-549 | TNBC | Basal B | ZM-447439 | AURK | AURK | 0.00064 | uM | 12305.169 | 1.0417 | 1.0320 | 2.5786 | |
| BT-549 | TNBC | Basal B | ZM-447439 | AURK | AURK | 0.0032 | uM | 12305.169 | 1.0538 | 1.0410 | 2.5786 | |
| BT-549 | TNBC | Basal B | ZM-447439 | AURK | AURK | 0.016 | uM | 12305.169 | 1.1311 | 1.0978 | 2.5786 | |
| BT-549 | TNBC | Basal B | ZM-447439 | AURK | AURK | 0.08 | uM | 12305.169 | 1.0320 | 1.0246 | 2.5786 | |
| BT-549 | TNBC | Basal B | ZM-447439 | AURK | AURK | 0.4 | uM | 12305.169 | 1.0207 | 1.0159 | 2.5786 | |
| BT-549 | TNBC | Basal B | ZM-447439 | AURK | AURK | 2 | uM | 12305.169 | 0.8382 | 0.8677 | 2.5786 |