Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| BT-549 | TNBC | Basal B | Vorinostat | HDAC | HDAC | 150 | uM | 5909.065 | 0.5247 | 0.5870 | 2.7890 | |
| BT-549 | TNBC | Basal B | Vorinostat | HDAC | HDAC | 750 | uM | 5909.065 | 0.1483 | 0.0088 | 2.7890 | |
| BT-549 | TNBC | Basal B | Vorinostat | HDAC | HDAC | 3750 | uM | 5909.065 | 0.0134 | -0.5734 | 2.7890 | |
| BT-549 | TNBC | Basal B | Vorinostat | HDAC | HDAC | 18700 | uM | 5909.065 | 0.0127 | -0.5822 | 2.7890 | |
| BT-549 | TNBC | Basal B | Vorinostat | HDAC | HDAC | 0.048 | uM | 5910.065 | 0.9946 | 0.9966 | 3.2016 | |
| BT-549 | TNBC | Basal B | Vorinostat | HDAC | HDAC | 0.24 | uM | 5910.065 | 1.0944 | 1.0572 | 3.2016 | |
| BT-549 | TNBC | Basal B | Vorinostat | HDAC | HDAC | 1.2 | uM | 5910.065 | 1.0449 | 1.0276 | 3.2016 | |
| BT-549 | TNBC | Basal B | Vorinostat | HDAC | HDAC | 6 | uM | 5910.065 | 1.0840 | 1.0510 | 3.2016 | |
| BT-549 | TNBC | Basal B | Vorinostat | HDAC | HDAC | 30 | uM | 5910.065 | 1.0349 | 1.0215 | 3.2016 | |
| BT-549 | TNBC | Basal B | Vorinostat | HDAC | HDAC | 150 | uM | 5910.065 | 0.5258 | 0.6362 | 3.2016 | |
| BT-549 | TNBC | Basal B | Vorinostat | HDAC | HDAC | 750 | uM | 5910.065 | 0.1577 | 0.1233 | 3.2016 | |
| BT-549 | TNBC | Basal B | Vorinostat | HDAC | HDAC | 3750 | uM | 5910.065 | 0.0089 | -0.5426 | 3.2016 | |
| BT-549 | TNBC | Basal B | Vorinostat | HDAC | HDAC | 18700 | uM | 5910.065 | 0.0131 | -0.4837 | 3.2016 | |
| CAMA-1 | HR+ | Luminal | Vorinostat | HDAC | HDAC | 0.048 | uM | 5911.065 | 1.0011 | 1.0028 | 0.7592 | |
| CAMA-1 | HR+ | Luminal | Vorinostat | HDAC | HDAC | 0.24 | uM | 5911.065 | 0.9692 | 0.9193 | 0.7592 | |
| CAMA-1 | HR+ | Luminal | Vorinostat | HDAC | HDAC | 1.2 | uM | 5911.065 | 1.0075 | 1.0197 | 0.7592 | |
| CAMA-1 | HR+ | Luminal | Vorinostat | HDAC | HDAC | 6 | uM | 5911.065 | 1.0196 | 1.0517 | 0.7592 | |
| CAMA-1 | HR+ | Luminal | Vorinostat | HDAC | HDAC | 30 | uM | 5911.065 | 0.9742 | 0.9323 | 0.7592 | |
| CAMA-1 | HR+ | Luminal | Vorinostat | HDAC | HDAC | 150 | uM | 5911.065 | 0.4656 | -0.2692 | 0.7592 | |
| CAMA-1 | HR+ | Luminal | Vorinostat | HDAC | HDAC | 750 | uM | 5911.065 | 0.1221 | -0.8747 | 0.7592 | |
| CAMA-1 | HR+ | Luminal | Vorinostat | HDAC | HDAC | 3750 | uM | 5911.065 | 0.1729 | -0.8019 | 0.7592 | |
| CAMA-1 | HR+ | Luminal | Vorinostat | HDAC | HDAC | 18700 | uM | 5911.065 | 0.1757 | -0.7977 | 0.7592 | |
| CAMA-1 | HR+ | Luminal | Vorinostat | HDAC | HDAC | 0.048 | uM | 5912.065 | 0.9745 | 0.9557 | 1.1516 | |
| CAMA-1 | HR+ | Luminal | Vorinostat | HDAC | HDAC | 0.24 | uM | 5912.065 | 0.9870 | 0.9774 | 1.1516 | |
| CAMA-1 | HR+ | Luminal | Vorinostat | HDAC | HDAC | 1.2 | uM | 5912.065 | 0.9709 | 0.9494 | 1.1516 |