Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| CAMA-1 | HR+ | Luminal | Vorinostat | HDAC | HDAC | 6 | uM | 5912.065 | 0.9366 | 0.8894 | 1.1516 | |
| CAMA-1 | HR+ | Luminal | Vorinostat | HDAC | HDAC | 30 | uM | 5912.065 | 0.9093 | 0.8416 | 1.1516 | |
| CAMA-1 | HR+ | Luminal | Vorinostat | HDAC | HDAC | 150 | uM | 5912.065 | 0.2811 | -0.3356 | 1.1516 | |
| CAMA-1 | HR+ | Luminal | Vorinostat | HDAC | HDAC | 750 | uM | 5912.065 | 0.0146 | -0.9490 | 1.1516 | |
| CAMA-1 | HR+ | Luminal | Vorinostat | HDAC | HDAC | 3750 | uM | 5912.065 | 0.0312 | -0.9016 | 1.1516 | |
| CAMA-1 | HR+ | Luminal | Vorinostat | HDAC | HDAC | 18700 | uM | 5912.065 | 0.0156 | -0.9461 | 1.1516 | |
| HCC1143 | TNBC | Basal A | Vorinostat | HDAC | HDAC | 0.048 | uM | 7430.065 | 0.9385 | 0.9351 | 1.9263 | |
| HCC1143 | TNBC | Basal A | Vorinostat | HDAC | HDAC | 0.24 | uM | 7430.065 | 1.0505 | 1.0518 | 1.9263 | |
| HCC1143 | TNBC | Basal A | Vorinostat | HDAC | HDAC | 1.2 | uM | 7430.065 | 0.9732 | 0.9720 | 1.9263 | |
| HCC1143 | TNBC | Basal A | Vorinostat | HDAC | HDAC | 6 | uM | 7430.065 | 1.0191 | 1.0197 | 1.9263 | |
| HCC1143 | TNBC | Basal A | Vorinostat | HDAC | HDAC | 30 | uM | 7430.065 | 0.9114 | 0.9060 | 1.9263 | |
| HCC1143 | TNBC | Basal A | Vorinostat | HDAC | HDAC | 150 | uM | 7430.065 | 0.5611 | 0.4816 | 1.9263 | |
| HCC1143 | TNBC | Basal A | Vorinostat | HDAC | HDAC | 750 | uM | 7430.065 | 0.1996 | -0.1335 | 1.9263 | |
| HCC1143 | TNBC | Basal A | Vorinostat | HDAC | HDAC | 3750 | uM | 7430.065 | 0.1437 | -0.2696 | 1.9263 | |
| HCC1143 | TNBC | Basal A | Vorinostat | HDAC | HDAC | 18700 | uM | 7430.065 | 0.1148 | -0.3499 | 1.9263 | |
| HCC1187 | TNBC | Basal A | Vorinostat | HDAC | HDAC | 0.048 | uM | 7431.065 | 1.0175 | 1.0238 | 1.4650 | |
| HCC1187 | TNBC | Basal A | Vorinostat | HDAC | HDAC | 0.24 | uM | 7431.065 | 1.0360 | 1.0489 | 1.4650 | |
| HCC1187 | TNBC | Basal A | Vorinostat | HDAC | HDAC | 1.2 | uM | 7431.065 | 0.9913 | 0.9881 | 1.4650 | |
| HCC1187 | TNBC | Basal A | Vorinostat | HDAC | HDAC | 6 | uM | 7431.065 | 0.9977 | 0.9969 | 1.4650 | |
| HCC1187 | TNBC | Basal A | Vorinostat | HDAC | HDAC | 30 | uM | 7431.065 | 0.7325 | 0.6172 | 1.4650 | |
| HCC1187 | TNBC | Basal A | Vorinostat | HDAC | HDAC | 150 | uM | 7431.065 | 0.0690 | -0.6777 | 1.4650 | |
| HCC1187 | TNBC | Basal A | Vorinostat | HDAC | HDAC | 750 | uM | 7431.065 | 0.0238 | -0.8441 | 1.4650 | |
| HCC1187 | TNBC | Basal A | Vorinostat | HDAC | HDAC | 3750 | uM | 7431.065 | 0.0199 | -0.8622 | 1.4650 | |
| HCC1187 | TNBC | Basal A | Vorinostat | HDAC | HDAC | 18700 | uM | 7431.065 | 0.0160 | -0.8812 | 1.4650 | |
| HCC1187 | TNBC | Basal A | Vorinostat | HDAC | HDAC | 0.048 | uM | 7432.065 | 1.0282 | 1.0710 | 0.7981 |