Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| BT-474 | HER2amp | Luminal | Vorinostat | HDAC | HDAC | 3750 | uM | 5905.065 | 0.0388 | -0.9570 | 0.8461 | |
| BT-474 | HER2amp | Luminal | Vorinostat | HDAC | HDAC | 18700 | uM | 5905.065 | 0.0339 | -0.9633 | 0.8461 | |
| BT-474 | HER2amp | Luminal | Vorinostat | HDAC | HDAC | 0.048 | uM | 5906.065 | 0.9933 | 0.9798 | 0.6586 | |
| BT-474 | HER2amp | Luminal | Vorinostat | HDAC | HDAC | 0.24 | uM | 5906.065 | 1.0631 | 1.1948 | 0.6586 | |
| BT-474 | HER2amp | Luminal | Vorinostat | HDAC | HDAC | 1.2 | uM | 5906.065 | 1.0051 | 1.0155 | 0.6586 | |
| BT-474 | HER2amp | Luminal | Vorinostat | HDAC | HDAC | 6 | uM | 5906.065 | 0.9540 | 0.8620 | 0.6586 | |
| BT-474 | HER2amp | Luminal | Vorinostat | HDAC | HDAC | 30 | uM | 5906.065 | 0.8827 | 0.6548 | 0.6586 | |
| BT-474 | HER2amp | Luminal | Vorinostat | HDAC | HDAC | 150 | uM | 5906.065 | 0.4344 | -0.4361 | 0.6586 | |
| BT-474 | HER2amp | Luminal | Vorinostat | HDAC | HDAC | 750 | uM | 5906.065 | 0.0331 | -0.9887 | 0.6586 | |
| BT-474 | HER2amp | Luminal | Vorinostat | HDAC | HDAC | 3750 | uM | 5906.065 | 0.0274 | -0.9915 | 0.6586 | |
| BT-474 | HER2amp | Luminal | Vorinostat | HDAC | HDAC | 18700 | uM | 5906.065 | 0.0249 | -0.9927 | 0.6586 | |
| BT-483 | HR+ | Luminal | Vorinostat | HDAC | HDAC | 0.048 | uM | 5908.065 | 0.9343 | 0.7520 | 0.5136 | |
| BT-483 | HR+ | Luminal | Vorinostat | HDAC | HDAC | 0.24 | uM | 5908.065 | 0.9788 | 0.9184 | 0.5136 | |
| BT-483 | HR+ | Luminal | Vorinostat | HDAC | HDAC | 1.2 | uM | 5908.065 | 0.9612 | 0.8518 | 0.5136 | |
| BT-483 | HR+ | Luminal | Vorinostat | HDAC | HDAC | 6 | uM | 5908.065 | 0.9401 | 0.7734 | 0.5136 | |
| BT-483 | HR+ | Luminal | Vorinostat | HDAC | HDAC | 30 | uM | 5908.065 | 0.9043 | 0.6442 | 0.5136 | |
| BT-483 | HR+ | Luminal | Vorinostat | HDAC | HDAC | 150 | uM | 5908.065 | 0.7437 | 0.1237 | 0.5136 | |
| BT-483 | HR+ | Luminal | Vorinostat | HDAC | HDAC | 750 | uM | 5908.065 | 0.4220 | -0.6272 | 0.5136 | |
| BT-483 | HR+ | Luminal | Vorinostat | HDAC | HDAC | 3750 | uM | 5908.065 | 0.1995 | -0.9133 | 0.5136 | |
| BT-483 | HR+ | Luminal | Vorinostat | HDAC | HDAC | 18700 | uM | 5908.065 | 0.1724 | -0.9347 | 0.5136 | |
| BT-549 | TNBC | Basal B | Vorinostat | HDAC | HDAC | 0.048 | uM | 5909.065 | 0.9987 | 0.9991 | 2.7890 | |
| BT-549 | TNBC | Basal B | Vorinostat | HDAC | HDAC | 0.24 | uM | 5909.065 | 1.0391 | 1.0277 | 2.7890 | |
| BT-549 | TNBC | Basal B | Vorinostat | HDAC | HDAC | 1.2 | uM | 5909.065 | 1.0136 | 1.0097 | 2.7890 | |
| BT-549 | TNBC | Basal B | Vorinostat | HDAC | HDAC | 6 | uM | 5909.065 | 1.0545 | 1.0384 | 2.7890 | |
| BT-549 | TNBC | Basal B | Vorinostat | HDAC | HDAC | 30 | uM | 5909.065 | 0.9419 | 0.9576 | 2.7890 |